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PDZK1 encodes a PDZ domain-containing scaffolding protein. Additionally we are shipping PDZK1 Antibodies (121) and PDZK1 Proteins (6) and many more products for this protein.
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These findings have provided first lines of evidences that PDZK1 expression is negatively correlated with SHP-1 activation and poor clinical outcomes in clear cell renal cell carcinoma (ccRCC) . PDZK1 was identified as a novel tumor suppressor in ccRCC by negating SHP-1 activity
HNF1alpha (show HNF1A ELISA Kits), which has previously been described as a modulator of several transporters of the renal transportosome, is also a key determinant of PDZK1 transcription.
a PDZK1 single nucleotide polymorphism rs12129861 was found to be significantly associated with gout susceptibility (meta-analysis)
PDZK1 was defined as an independent prognostic factor for both OS and DFS (show FST ELISA Kits). These findings indicated that low level of PDZK1 could predict poor clinical outcome in patients with ccRCC.
Inflammation-induced loss of PDZK1 expression may contribute to the NHE3 (show SLC9A3 ELISA Kits) dysfunction observed in the inflamed intestine.
PARP (show COL11A2 ELISA Kits) regulates estradiol-mediated cell growth by controlling the ER/IGF-1R (show IGF1R ELISA Kits)/PDZK1 axis.
PDZK1, negatively regulates 5-HT2AR endocytosis and has no effect upon 5-HT2AR-mediated ERK1/2 (show MAPK1/3 ELISA Kits) phosphorylation.
Described is a structure of D-AKAP2 (show AKAP10 ELISA Kits) in complex with two interacting partners and the exact mechanism by which a segment that on its own is disordered presents an alpha-helix to PKA and a beta-strand to PDZK1.
PDZK1 and NHERF1 regulate the transport function of OATP1A2 by modulating protein internalization via a clathrin-dependent pathway and by enhancing protein stability.
Correlation between PDZK1, Cdc37 (show CDC37 ELISA Kits), Akt (show AKT1 ELISA Kits) and breast cancer malignancy: the role of PDZK1 in cell growth through Akt (show AKT1 ELISA Kits) stabilization by increasing and interacting with Cdc37 (show CDC37 ELISA Kits)
These results suggest that the PDZ domain of PICK1 (show PICK1 ELISA Kits) directly interacts with calcineurin B in osteoclast progenitor cells and promotes osteoclast differentiation through activation of calcineurin-NFAT (show NFATC1 ELISA Kits) signaling.
PDZK1 has novel SR-BI (show SCARB1 ELISA Kits)-independent function in VSM that affords protection from neointima formation, and this involves PDZK1 suppression of VSM cell proliferation via an inhibitory interaction with Bcr (show BCR ELISA Kits)
Data show that interaction of the inducible nitric oxide synthase (iNOS (show NOS2 ELISA Kits)) C-terminus with the PDZ domains of EBP50 protein or Pdzk1 protein CAP70 resulted greater nitric oxide (NO) synthesis.
PDZK1 regulates intracellular trafficking of Oatp1a1 (show Slco1a1 ELISA Kits).
PDZK1(NHERF3) is entirely non-raft associated with lipid rafts in brush border membrane fractions of NHE3 (show SLC9A3 ELISA Kits).
NHERF3 is a key regulator of organic transport in the kidney, particularly MRP4-mediated clearance of drug molecules.
SR-BI (show SCARB1 ELISA Kits) and PDZK1 protein and mRNA expression levels fell rapidly in primary hepatocyte cultures, indicating this system does not adequately mimic hepatocytes in vivo for analysis of the PDZK1 dependence of SR-BI (show SCARB1 ELISA Kits).
the localization of PDZK1 on hepatocyte cell surface membranes in vivo is dependent on its PDZ4 domain and the presence of SR-BI (show SCARB1 ELISA Kits).
The impairment of the absorptive function of the inflamed colon in the IL-10 (show IL10 ELISA Kits)(-/-) mouse, in spite of unaltered NHE3 (show SLC9A3 ELISA Kits) expression and localization, is accompanied by the downregulation of the NHE3 (show SLC9A3 ELISA Kits)-regulatory PDZ adaptors NHERF2 and PDZK1.
This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
PDZ domain containing 1
, Na(+)/H(+) exchange regulatory cofactor NHE-RF3-like
, CFTR-associated protein of 70 kDa
, Na(+)/H(+) exchange regulatory cofactor NHE-RF3
, PDZ-containing kidney protein 1
, na/Pi cotransporter C-terminal-associated protein 1
, sodium-hydrogen exchanger regulatory factor 3
, Na(+)/H(+) exchanger regulatory factor 3
, PDZ domain-containing protein 1
, PDZK1-like protein
, C-terminal linking and modulating protein
, C-terminal-linking and modulating protein
, dietary Pi-regulated RNA-1