PHD Finger Protein 2 Proteins (PHF2)

PHF2 encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. Additionally we are shipping PHF2 Antibodies (39) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PHF2 5253 O75151
PHF2 18676 Q9WTU0
Rat PHF2 PHF2 306814  
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Top PHF2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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PHF2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for PHD Finger Protein 2 (PHF2) Interaction Partners

Human PHD Finger Protein 2 (PHF2) interaction partners

  1. Our results demonstrate that the IKAROS promotes PHF2 expression, and suggest that PHF2 (low) expression works with the IKAROS gene deletion to drive oncogenesis of ALL

  2. Frameshift mutations of PHF2 may play a role in tumorigenesis through its TSG inactivation in CRC and GC.

  3. PHF2 acts as a tumor suppressor in association with p53 in cancer development and ensures p53-mediated cell death in response to chemotherapy.

  4. PHF2 is likely to repress rDNA transcription by competing with PHF8 for binding of ribosomal DNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1.

  5. JARID1B and PHF2 are overexpressed in esophageal squamous cell carcinoma (ESCC) and they may play crucial roles in the course of ESCC initiation and/or progression

  6. the crystal structures of PHF2 Jumonji domain in the absence and presence of additional exogenous metal ions were determined.

  7. Differential association of alterations in FANCC and PTCH1 with that of PHF2, XPA and two breast cancer susceptibility genes (BRCA1/BRCA2) in the two age groups suggests differences in their molecular pathogenesis.

Mouse (Murine) PHD Finger Protein 2 (PHF2) interaction partners

  1. The paper's findings establish a downstream epigenetic checkpoint, whereby Phf2, through facilitating H3K9me2 demethylation at specific gene promoters, protects liver from the pathogenesis progression of Non-alcoholic Fatty Liver Disease.

  2. these results demonstrate that PHF2 histone demethylase controls adipogenic gene expression during differentiation.

  3. PHF2 enhances osteoblast differentiation by demethylating Runx2, while suppressor of variegation 3-9 homolog 1 (SUV39H1) inhibits bone formation by methylating it.

  4. Arid5b recruits Phf2 to the promoter region of Sox9 target genes and stimulates H3K9me2 demethylation of these genes.

  5. Data from PHF2 knockout mice suggest that PHF2 plays roles in both adipogenesis and neonatal growth/weight gain; PHF2 interacts with promoter region of CEBPA (CCAAT-enhancer binding protein alpha) gene and demethylates histones in chromatin.

  6. histone H3K4 trimethylation by a homeodomain of PHF2 modulates histone demethylation

PHF2 Protein Profile

Protein Summary

This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure.

Gene names and symbols associated with PHD Finger Protein 2 Proteins (PHF2)

  • PHD finger protein 2 (PHF2)
  • PHD finger protein 2 (Phf2)
  • PHD finger protein 2 (phf2)
  • CENP-35 protein
  • GRC5 protein
  • im:4200679 protein
  • JHDM1E protein
  • phf8 protein
  • wu:fa14c10 protein

Protein level used designations for PHD Finger Protein 2 Proteins (PHF2)

centromere protein 35 , jumonji C domain-containing histone demethylase 1E , lysine-specific demethylase PHF2 , PHD finger protein 8 , lysine-specific demethylase phf2 , PHD finger protein 2

GENE ID SPECIES
5253 Homo sapiens
18676 Mus musculus
503778 Danio rerio
415981 Gallus gallus
306814 Rattus norvegicus
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