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Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex.
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These findings establish a unique PHF20-mediated link between MOF (show KAT8 Antibodies) histone acetyltransferase (HAT (show HAT Antibodies)), p53 (show TP53 Antibodies), and dimethylated lysine 4 of histone H3 (show HIST3H3 Antibodies), and suggest a model for rapid spreading of H4K16ac-enriched open chromatin.
PHF20 may play an important role in Non-small-cell lung cancer (NSCLC).
Along with the PHF20/MOF (show KAT8 Antibodies) complex, G9a (show EHMT2 Antibodies) links the crosstalk between ERalpha (show ESR1 Antibodies) methylation and histone acetylation that governs the epigenetic regulation of hormonal gene expression.
suggests a del(20q)-independent decrease in PHF20 expression in primary myelofibrosis
Plant homeodomain finger protein 20 (PHF20) maintains NF-kappaB (show NFKB1 Antibodies) in an active state in the nucleus by inhibiting the interaction between PP2A (show PPP2R4 Antibodies) and p65 (show GORASP1 Antibodies).
PHF20 is a novel substrate for PKB (show AKT1 Antibodies) and its phosphorylation by PKB (show AKT1 Antibodies) plays an important role in tumorigenesis via regulating of p53 (show TP53 Antibodies) mediated signaling.
Association with PHF20 promotes stabilization and activation of p53 (show TP53 Antibodies) by diminishing Mdm2 (show MDM2 Antibodies)-mediated p53 (show TP53 Antibodies) ubiquitylation and degradation.
Data report the crystal structures of the N-terminal Tudor domains of PHF20 and highlight the novel structural features of each domain.
genetic alterations of TSPAN14, SLC2A13 (show SLC2A13 Antibodies) and PHF20 could play a role in non-small-cell lung cancer promotion
Survival of patients with GLEA2 antibodies was increased to 17.4 months and for patients with PHF3 antibodies to 14.7 months, as compared to 7.2 months for patients without GLEA2 or PHF3 antibodies in glioblastoma.
PHF20 is not required for maintaining the global H4K16 acetylation levels or locus specific histone acetylation but instead works downstream in transcriptional regulation of MOF (show KAT8 Antibodies) target genes
Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues.
glioma-expressed antigen 2
, hepatocellular carcinoma-associated antigen 58
, novel zinc finger protein
, transcription factor TZP
, tudor domain containing 20A
, hepatocellular carcinoma-associated antigen 58 homolog