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Transcriptional coactivator that specifically associates with either OCT1 or OCT2. Additionally we are shipping POU2AF1 Proteins (8) and POU2AF1 Kits (5) and many more products for this protein.
Showing 10 out of 157 products:
Human Monoclonal POU2AF1 Primary Antibody for WB - ABIN1882276
Galiègue-Zouitina, Quief, Hildebrand, Denis, Lecocq, Collyn-dHooghe, Bastard, Yuille, Dyer, Kerckaert: Fusion of the LAZ3/BCL6 and BOB1/OBF1 genes by t(3; 11) (q27; q23) chromosomal translocation. in Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1996
Show all 4 Pubmed References
Mouse (Murine) Polyclonal POU2AF1 Primary Antibody for ELISA, WB - ABIN249690
Strubin, Newell, Matthias: OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins. in Cell 1995
The number of follicular B2 lymphocytes and expression of the B-cell-specific transcriptional coactivator OcaB increase with age in spleen and in intra-abdominal epididymal white adipose tissue (eWAT), concomitantly with higher circulating levels of IgG and impaired glucose homeostasis.
These findings demonstrate for the first time that functional polymorphism in the 3'-UTR (show UTS2R Antibodies) of POU2AF1 is associated with susceptibility, and that single-nucleotide polymorphisms interaction with hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-633 affects gene expression and increases the risk of lymphoma.
Oct2 and Bob1 are very reliable in determining B cell lineage in the absence of expression of other pan (show SUPT6H Antibodies)-B cell markers
these findings suggest a novel function of POU2AF1 as a potential regulator of host defense genes in the human airway epithelium.
It has been identified as a new disease susceptibility gene among Japanese. Though different from Europeans, it is indicated that a B lymphocyte differentiation route shares a common disease developing process. [Review]
Two significant susceptibility loci, TNFSF15 (show TNFSF15 Antibodies) (rs4979462) and POU2AF1 (rs4938534) (combined odds ratio [OR] = 1.56, p = 2.84 x 10(-14) for rs4979462.
Data show that Igh 3' enhancer-bound OCA-B and promoter-bound TFII-I mediate promoter-enhancer interactions, in both cis and trans, that are important for Igh transcription.
Twenty-two cases of nodular lymphocyte predominant Hodgkin lymphoma were studied for the immunohistochemical expression of Pax-5 (show PAX5 Antibodies), Oct-2, BOB.1, Bcl-6 (show BCL6 Antibodies) protein and MUM1/IRF-4 (show IRF4 Antibodies).
On multivariate analysis, co-expression of OCT-2/BOB.1 remained predictive for achievement of complete remission and increased risk of relapse.
The expression of the octamer cofactor gene OBF-1 (Bob1/OCA-B) is sufficient to override the silencing effects of the B29 (show CD79B Antibodies) silencer, indicating that OBF-1 plays a critical role in B cell-specific B29 (show CD79B Antibodies) promoter expression.
Bob1 promotes the development of follicular T helper cells via Bcl6 (show BCL6 Antibodies).Bob1 is directly involved in follicular T helper cell differentiation and required for mounting normal T cell-dependent B-cell responses.
Findings indicate octamer transcription factor-1 (show HNF1A Antibodies) (Oct1 (show POU2F1 Antibodies)) and Oct binding factor 1 protein (OCA-B) as central mediators of CD4 (show CD4 Antibodies)(+) T cell memory.
overexpression of DDX60 (show DDX60 Antibodies) did not potentiate IFN induction
Loss of Obf1 is associated with IgM-mediated glomerulonephritis.
The transcription factor Bob1 counteracts B cell activation (show BLNK Antibodies) and regulates miR (show MLXIP Antibodies)-146a in B cells.
Expressing a stable Bob1 mutant in B cells suppresses cell proliferation and induces changes in surface marker expression commonly seen during B-cell differentiation.
Data show that IL-6 (show IL6 Antibodies) and IL-21 (show IL21 Antibodies) act with different kinetics during the germinal centers (GCs (show UGCG Antibodies)) response and that B cells, in an Oct2 (show SLC22A2 Antibodies)/OBF-1-dependent manner, can supply the IL-6 (show IL6 Antibodies) for early induction of T follicular helper cells (T(FH) development.
OcaB is essential for V(D)J recombination of a subset of Igkappa genes. We show that OcaB modulates recombination by directly enhancing Igkappa gene transcription in vivo.
Data show that the expression of BOB.1/OBF (show IZUMO1 Antibodies).1 in peripheral B cells is required for the development of marginal zone B lymphocytes.
Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.
B-cell-specific coactivator OBF-1
, OCT-binding factor 1
, POU domain class 2-associating factor 1
, POU domain, class 2, associating factor 1
, OCT binding factor 1