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POU2F3 encodes a member of the POU domain family of transcription factors. Additionally we are shipping POU Class 2 Homeobox 3 Antibodies (35) and POU Class 2 Homeobox 3 Proteins (6) and many more products for this protein.
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POU2F3 is a master regulator of tuft cell identity in a variant form of Small cell lung cancer
Analysis of the transcription factor POU2F3 revealed a DOPr-mediated extracellular signal-regulated kinase (ERK (show EPHB2 ELISA Kits))-dependent downregulation of this factorThe delta-opioid receptor affects epidermal homeostasis
These results suggested that the epidermal differentiation signaling pathway, involving kinase and phosphatase activation, may regulate the NLS (show ALDH1A2 ELISA Kits) activity of Skn1a in keratinocytes
Skn-1a is expressed in a minority of Mash1-positive olfactory progenitor cells and a majority of Trpm5-expressing microvillous cells in the main olfactory epithelium.
It is possible that Skn-1a and the related isoforms have different functions in keratinocyte differentiation and proliferation.
the antagonistic effects of Skn-1a and p63 on keratin promoter transactivation is probably through competition for overlapping binding sites on target gene promoter or through an indirect interaction.
the human Skn-1 locus encodes multifunctional protein isotypes, subjected to biochemical cross-talk, which are likely to play a major role in the fine-tuning of keratinocyte terminal differentiation
Pla-1 protein binds to a POU-consensus DNA sequence in the human placental lactogen (show CSH1 ELISA Kits)-3 (PL-3) promoter and it is capable of trans-activating its transcription up to 18-fold.
POU2F3 in cervical cancer cells may be CC-related tumor suppressor genes, which are disrupted by both epigenetic and genetic mechanisms.
Our results suggest that Tst-1 and Skn-1a regulate expression of MMPs in keratinocytes and effect both the expression and activation of these proteolytic enzymes.
Study demonstrated that Skn-1a is only expressed when neuropeptide Y (NPY (show NPY ELISA Kits)) is activated in microvillar cells (MVCs). Therefore the expression of NPY (show NPY ELISA Kits) is necessary for the transcription factor-mediated differentiation of olfactory MVCs.
propose that Skn-1a/Pou2f3 is the master regulator for the generation of the Trpm5-expressing microvillous cells in multiple tissues
Study reveals a large increase of sour taste receptor cells in Skn-1-deficient mice does not alter the number of their sour taste signal-transmitting gustatory neurons
Pou2f3/Skn-1a , which is necessary for generation of sweet, umami, and bitter taste cells, is also necessary for the generation or differentiation of solitary chemosensory cells
Oct-6 and Oct-11 contribute to the regulation of loricrin gene transcription via interaction with AP-1 factors and Sp1/Sp3.
Skn-1a is critical for generating and balancing the diverse composition of taste cells.
This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
POU class 2 homeobox 3
, POU domain, class 2, transcription factor 3
, POU transcription factor
, POU domain, class 2, transcription factor 3-like
, POU domain transcription factor OCT11a
, octamer-binding protein 11
, octamer-binding transcription factor 11
, transcription factor PLA-1
, transcription factor Skn-1
, Rov 1 pou-homeodomain protein
, nrl-16 Pou-homeobox protein