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POU2F3 encodes a member of the POU domain family of transcription factors. Additionally we are shipping POU Class 2 Homeobox 3 Antibodies (37) and POU Class 2 Homeobox 3 Proteins (6) and many more products for this protein.
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POU2F3 is a master regulator of tuft cell identity in a variant form of Small cell lung cancer
Analysis of the transcription factor POU2F3 revealed a DOPr-mediated extracellular signal-regulated kinase (ERK)-dependent downregulation of this factorThe delta-opioid receptor affects epidermal homeostasis
These results suggested that the epidermal differentiation signaling pathway, involving kinase and phosphatase activation, may regulate the NLS activity of Skn1a in keratinocytes
Skn-1a is expressed in a minority of Mash1-positive olfactory progenitor cells and a majority of Trpm5-expressing microvillous cells in the main olfactory epithelium.
It is possible that Skn-1a and the related isoforms have different functions in keratinocyte differentiation and proliferation.
the antagonistic effects of Skn-1a and p63 on keratin promoter transactivation is probably through competition for overlapping binding sites on target gene promoter or through an indirect interaction.
the human Skn-1 locus encodes multifunctional protein isotypes, subjected to biochemical cross-talk, which are likely to play a major role in the fine-tuning of keratinocyte terminal differentiation
These results suggest that the expression of hSkn-1a represses the growth of the cervical cancer cells through the partial resumption of the differentiation pathway followed by slow suppression of cell replication and apoptosis.
Pla-1 protein binds to a POU-consensus DNA sequence in the human placental lactogen-3 (PL-3) promoter and it is capable of trans-activating its transcription up to 18-fold.
POU2F3 in cervical cancer cells may be CC-related tumor suppressor genes, which are disrupted by both epigenetic and genetic mechanisms.
Our results suggest that Tst-1 and Skn-1a regulate expression of MMPs in keratinocytes and effect both the expression and activation of these proteolytic enzymes.
splice variant induced in keratinocytes by high calcium
Skn-1a enhanced the transient replication of a plasmid containing the HPV16 replication origin in HEK293 cells when co-transfected with a plasmid expressing E1 and E2.
Study demonstrated that Skn-1a is only expressed when neuropeptide Y (NPY) is activated in microvillar cells (MVCs). Therefore the expression of NPY is necessary for the transcription factor-mediated differentiation of olfactory MVCs.
propose that Skn-1a/Pou2f3 is the master regulator for the generation of the Trpm5-expressing microvillous cells in multiple tissues
Study reveals a large increase of sour taste receptor cells in Skn-1-deficient mice does not alter the number of their sour taste signal-transmitting gustatory neurons
Pou2f3/Skn-1a , which is necessary for generation of sweet, umami, and bitter taste cells, is also necessary for the generation or differentiation of solitary chemosensory cells
Oct-6 and Oct-11 contribute to the regulation of loricrin gene transcription via interaction with AP-1 factors and Sp1/Sp3.
Skn-1a is critical for generating and balancing the diverse composition of taste cells.
This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
POU class 2 homeobox 3
, POU domain, class 2, transcription factor 3
, POU transcription factor
, POU domain, class 2, transcription factor 3-like
, POU domain transcription factor OCT11a
, octamer-binding protein 11
, octamer-binding transcription factor 11
, transcription factor PLA-1
, transcription factor Skn-1
, Rov 1 pou-homeodomain protein
, nrl-16 Pou-homeobox protein