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PRDM14 encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. Additionally we are shipping PRDM14 Proteins (5) and PRDM14 Kits (1) and many more products for this protein.
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Human Polyclonal PRDM14 Primary Antibody for IF, IHC (p) - ABIN388018
Jiang, Huang: The yin-yang of PR-domain family genes in tumorigenesis. in Histology and histopathology 2000
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Cow (Bovine) Polyclonal PRDM14 Primary Antibody for ELISA - ABIN4239519
Chia, Chan, Feng, Lu, Orlov, Moreau, Kumar, Yang, Jiang, Lau, Huss, Soh, Kraus, Li, Lufkin, Lim, Clarke, Bard, Ng: A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. in Nature 2010
Our results suggest that PRDM14 serves as an initial trigger for epigenetic changes and hyperdynamic plasticity in tumors via bivalent chromatin domains.
Results identified GRP78 (show HSPA5 Antibodies) and HSP90a (show HSP90AA1 Antibodies) as binding partners of PRDM14 in triple-negative breast cancer cells, and all participate in cancer regulation. The interactions were direct and required the C-terminal region including the zinc finger motifs of PRDM14.
miR (show MLXIP Antibodies)-424-->cdc42 (show CDC42 Antibodies)-->prdm14 axis as a key molecular signalling cascade that might influence breast cancer progression in diabetic patients through hyperactivation of cancer stem cells.
High expression of PRDM14 is associated with liver metastasis in pancreatic cancer.
PRDM14 role in cell proliferation and cell migration
PRDM14 bears a single PR domain and six tandemly repeated zinc fi ngers, which is involved in the process of the deacetylation and methylation of the histone, and is involved in the formation of tumor . [review]
In response to cytokines, pluripotent stem cells differentiate first into a heterogeneous mesoderm-like cell population and then into Primordial Germ cell-Like Cells, which exhibit minimal PRDM14 expression.
The contribution of methylation-mediated gene silencing of PRDM14 to apoptosis evasion in HPV-positive cancer cells offers novel therapeutic options for HPV-induced cancers.
PRDM14 associated with cell differentiation in NSCLC.
Study reveals a repressive role of PRDM14 in the maintenance and induction of pluripotency and identifies PRDM14 as a new regulator of PRC2.
PRDM14 recruited OCT3/4 (show POU5F1 Antibodies) to the enhancer regions of naive pluripotency genes via TET-base excision repair-mediated demethylation.
JARID2 (show JARID2 Antibodies) physically interacts with ESRRB (show ESRRB Antibodies), SALL4A (show SALL4 Antibodies), and PRDM14
This repressive function is mediated through an ETO (show RUNX1T1 Antibodies)-family co-repressor Mtgr1 (show CBFA2T2 Antibodies), which tightly binds to the pre-SET/SET domains of Prdm14 and co-occupies its genomic targets in mouse embryonic stem cells.
the H3K27-specific demethylase (show MBD2 Antibodies) Utx (show KDM6A Antibodies) regulates the expression of the master regulators for XCI and XCR: Prdm14, Tsix, and Xist.
Both TET1 (show TET1 Antibodies) and TET2 (show TET2 Antibodies) are required for the repression of embryonic stem cells differentiation by PRDM14.
Upregulation of Prdm14 results in a highly homogeneous population of authentic pluripotent colonies and prevents the abnormal silencing of the Dlk1 (show DLK1 Antibodies)-Dio3 (show DIO3 Antibodies) locus.
PRDM14 is heterogeneously expressed in 4-cell-stage embryos. Forced expression of PRDM14 at the 2-cell stage leads to increased H3R26me2 and can induce a pluripotent ICM fate.
PRDM14-induced leukemic cells contain high levels of activated NOTCH1 (show NOTCH1 Antibodies) and downstream NOTCH1 (show NOTCH1 Antibodies) targets, including MYC (show MYC Antibodies) and HES1 (show HES1 Antibodies), and are sensitive to pharmacological inhibition of NOTCH1 (show NOTCH1 Antibodies) with the gamma-secretase inhibitor DAPT
PRDM14 physically interacts with TET1 (show TET1 Antibodies) and TET2 (show TET2 Antibodies) and enhances the recruitment of TET1 (show TET1 Antibodies) and TET2 (show TET2 Antibodies) at target loci. Knockdown of TET1 (show TET1 Antibodies) and TET2 (show TET2 Antibodies) impaired transcriptional regulation and DNA demethylation by PRDM14.
Prdm14 regulates Caudal (show CAD Antibodies) primary axon outgrowth through activation of islet2 expression.
This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer.
PR domain zinc finger protein 14
, PR domain-containing protein 14
, PR domain containing 14
, PR domain zinc finger protein 14-like
, PR domain 14
, PR domain containing 14-like