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This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. Additionally we are shipping PRDM2 Proteins (5) and many more products for this protein.
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Human Monoclonal PRDM2 Primary Antibody for ChIP, WB - ABIN387783
Lakshmikuttyamma, Takahashi, Pastural, Torlakovic, Amin, Garcia-Manero, Voralia, Czader, DeCoteau, Geyer: RIZ1 is potential CML tumor suppressor that is down-regulated during disease progression. in Journal of hematology & oncology 2009
Show all 2 Pubmed References
Promoter hypermethylation may play an important role in the epigenetic silencing of RIZ1 expression in human glioma tissues and glioblastoma cell lines.
the Pro704 p-/- allele of RIZ is significantly more common in CML patients with Loss of hematological response than good responders (p = .001). We showed that LOH p-/- homozygosity of RIZ1 was common event in BC than proline p+/+ homozygosity and proline p+/+ homozygosity more common feature in CP phase CML.
Promoter region methylation of RIZ1 may play an important role in the epigenetic silencing of RIZ1 expression in pituitary adenomas, which may translate into important diagnostic and therapeutic applications
RIZ1 expression is negatively correlated with glioma differentiation and can serve as a predictor of glioma prognosis and thus could be a potential therapeutic target for patients with gliomas.
Loss of RIZ1 expression due to methylation is associated with Renal Cell Carcinoma (show MOK Antibodies).
PRDM2 downregulation may play a role in dopamine-agonist resistance and tumor recurrence in prolactinomas.
Results suggest that high expression of SMYD3 (show SMYD3 Antibodies) is related to the occurrence of esophageal squamous cell carcinoma. Also, its suppression promoted the expression of RIZ1 suggesting a signal transduction pathway between SMYD3 (show SMYD3 Antibodies) and RIZ1.
PRDM2, PRDM5 (show PRDM5 Antibodies), PRDM16 (show PRDM16 Antibodies) promoters are methylated and their expression is suppressed in lung cancer cells.
The development and progression of esophageal squamous cell carcinoma are related to the inactivation of RIZ1.
RIZ1 expression is significantly downregulated as the formation of meningiomas progressed, and suggest that RIZ1 may represent a promising candidate tumor suppressor gene that contributes to malignant meningiomas.
RIZ1 is an important regulator of both Akt3 (show AKT3 Antibodies) transcription and AKT (show AKT1 Antibodies) phosphorylation and suggest a role for RIZ1 in HF-induced obesity and the AKT (show AKT1 Antibodies) pathway
RIZ1 might participate osteoclast formation through the regulation of NFATc1 (show NFATC1 Antibodies) expression.
Data suggest that the histone methyltransferase RIZ1 is required for estrogen response in female reproductive tissues and that estrogen-bound estrogen receptors may turn a transcriptional repressor into a coactivator.
This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene.
PR domain containing 2, with ZNF domain
, retinoblastoma protein-binding zinc finger protein-like
, PR domain zinc finger protein 2-like
, GATA-3 binding protein G3B
, GATA-3-binding protein G3B
, MTE-binding protein
, PR domain zinc finger protein 2
, PR domain-containing protein 2
, lysine N-methyltransferase 8
, retinoblastoma protein-binding zinc finger protein
, retinoblastoma protein-interacting zinc finger protein
, zinc finger protein RIZ
, zinc-finger DNA-binding protein
, retinoblastoma interacting zinc finger protein