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Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. Additionally we are shipping PILRA Antibodies (42) and PILRA Proteins (9) and many more products for this protein.
PILRalpha exhibits large conformational change to recognize simultaneously both the sTn (show EEF1A2 ELISA Kits) O-glycan and the compact peptide structure constrained by proline residues
These results contribute our knowledge of the biological functions of HBVDNAPTP1 and provide novel data to aid in the further analysis of the regulatory mechanism of this protein.
The authors show that the human ocular and highly neurovirulent HSV-1 strain McKrae enters substantially more efficiently into cells via the gB-specific human paired immunoglobulin-like type-2 receptor-alpha (hPILR-alpha).
Data show that PILRalpha/ligand interactions require conserved PILRalpha arginine (Arg)-133 (mouse) and Arg-126 (human).
These results suggest that PANP is involved in immune regulation as a ligand of the PILRalpha.
Insertional mutations of gB reduced cell fusion activity when PILRalpha was overexpressed much more than nectin-1 (show PVRL1 ELISA Kits).
Thus, Leda-1/Pianp is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10 (show ADAM10 ELISA Kits)/17 and intramembrane protease gamma-secretase.
demonstrate that counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilralpha is part of the complex innate immune response of macrophages and its genetically determined strain-specific modulation
Data indicate paired Ig-like type 2 receptor (PILR)alpha Pilra-/- mice develop enhanced autoimmune arthritis.
Activation of PILRa or deletion of PILRb (show PILRB ELISA Kits) helps to control acute Staphylococcus aureus-mediated pneumonia and attenuate the inflammatory response.
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.
paired immunoglobulin-like type 2 receptor alpha
, paired immunoglobin-like type 2 receptor alpha
, cell surface receptor FDF03
, inhibitory receptor PILR-alpha