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Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene\; the core-binding sequence is 5'CAGGTG-3'. Additionally we are shipping PNN Antibodies (80) and PNN Proteins (3) and many more products for this protein.
These data suggest that lowering of PNN levels in epithelial cells results in dramatic transformation in the number and composition of splicing variants and that PNN plays a crucial role in the selection of which RNA isoforms differentiating cells produce.
PNN has an important role in alternative splicing of a specific subset of lncRNAs of the corneal epithelium.
ESRP1 (show ESRP1 ELISA Kits) and PNN modulate alternative splicing of a specific subset of target genes, but not general splicing events, in HCET cells to maintain or enhance epithelial characteristics.
Pinin functions as a splicing regulator (show PTBP2 ELISA Kits) which participates itself directly in splicing reaction or indirectly via other components of splicing machinery
Pnn may participate, via its interaction with RNPS1 (show RNPS1 ELISA Kits), in mRNA metabolism in the nucleus, including mRNA splicing and export
the interaction of Pnn with the corepressor CtBP1 (show CTBP1 ELISA Kits) may modulate repression of E-cadherin (show CDH1 ELISA Kits) transcription by CtBP1 (show CTBP1 ELISA Kits)
Pnn may play a general role in the control of the cellular amount of family SR proteins through down-regulation of its own expression
Corepressor CtBP (show CTBP2 ELISA Kits) and PNN/DRS differentially modulate transcription and splicing of the E-cadherin (show CDH1 ELISA Kits) gene.
pnn is essential for the maintenance of subsets of neural crest cells, and that in zebrafish proper cranial neural crest proliferation and differentiation are dependent on pnn expression.
Pnn has an important role in alternative splicing of a specific subset of lncRNAs of the corneal epithelium.
Pnn downregulation in skeletal muscle causes a muscular dystrophic phenotype associated with NEB (show NEB ELISA Kits) deficiency and the CCD (show RUNX2 ELISA Kits) domain is incapable of replacing full length Pnn in terms of functional capacity.
Loss of Pnn induces apoptotic morphology in embryonic stem cells.
The results suggest that astrocytes are unique among cell types of neuroblast origin in terms of expression Pinin protein.
Pinin modulates expression of an intestinal homeobox (show PRRX1 ELISA Kits) gene, Cdx2 (show CDX2 ELISA Kits), and plays an essential role for small intestinal morphogenesis
Spatial and temporal expression profile of pinin during mouse development.
demonstrate abnormal activities of Tcf (show HNF4A ELISA Kits)/Lef transcription factors, and alterations in beta-catenin (show CTNNB1 ELISA Kits) level in multiple Pnn hypomorphic tissues
Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene\; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion (By similarity).
140 kDa nuclear and cell adhesion-related phosphoprotein
, SR-like protein
, desmosome-associated protein
, domain-rich serine protein
, melanoma metastasis clone A protein
, neutrophil protein
, nuclear protein SDK3
, pinin, desmosome associated protein
, PININ protein