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PLXNC1 encodes a member of the plexin family.
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PLXNC1 and RDH13 (show RDH13 Proteins) are associated with bilateral convergent strabismus (show VANGL2 Proteins) with exophthalmus in German Brown cattle.
Structural basis for activation and non-canonical catalysis of the Rap (show LRPAP1 Proteins) GTPase activating protein (show RASA1 Proteins) domain of plexin c1 has been described.
Plexin C1 deficiency permits synaptotagmin 7 (show SYT7 Proteins)-mediated macrophage migration and enhances mammalian lung fibrosis
loss of Plexin C1 in melanoma may promote early steps in melanoma progression through suppression of migration and proliferation
Study reports the structures of Sema7A and A39R complexed with the Semaphorin-binding module of PlexinC1; both structures show two PlexinC1 molecules symmetrically bridged by Semaphorin dimers.
GTP (show AK3 Proteins)-bound form of Rab7 (show RAB7B Proteins) promotes melanogenesis through the regulation of gp100 (show PMEL Proteins) maturation in melanoma cells.
Plexin C1, a receptor for semaphorin 7a (show SEMA7A Proteins), inactivates cofilin (show CFL1 Proteins) and is a potential tumor suppressor for melanoma progression.
significant loss of Plexin C1 in metastatic melanoma compared with primary melanoma, suggesting the possibility that the Plexin C1 receptor is a tumor suppressor protein (show TP53 Proteins) for melanoma
Plxnc1 interaction with Sema7a (show SEMA7A Proteins) mediates repulsion of ventral tegmental area neurons.Lmx1a and Lmx1b (show LMX1B Proteins) regulate Plxnc1 expression.
These results implicate an important role of PLXNC1 during an acute inflammatory response and indicate PLXNC1 as a potential target for the control of conditions associated with acute inflammation.
Plexin-C1 displayed R-Ras GAP (show RASA3 Proteins) activity and inhibited cell migration
This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene.
, plexin (semaphorin receptor)
, receptor for viral semaphorin protein
, receptor for virally-encoded semaphorin
, virus-encoded semaphorin protein receptor
, viral-encoded semaphorin protein receptor