Plexin D1 Proteins (PLXND1)

Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Additionally we are shipping Plexin D1 Antibodies (71) and Plexin D1 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PLXND1 23129 Q9Y4D7
PLXND1 67784 Q3UH93
Rat PLXND1 PLXND1 312652  
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Top Plexin D1 Proteins at antibodies-online.com

Showing 2 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details

PLXND1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

More Proteins for Plexin D1 (PLXND1) Interaction Partners

Human Plexin D1 (PLXND1) interaction partners

  1. the receptor Plexin-D1 contains a sorting motif that interacts with the adaptor protein GIPC1 (show GIPC1 Proteins) to facilitate transport to recycling endosomes.

  2. SNPs associated with type 2 diabetes and obesity may also increase the risk of developing gestational diabetes mellitus (GDM) in the Chinese population. Among these SNPs, we report for the first time that rs945508 in ARHGEF11 (show ARHGEF11 Proteins), rs10804591 in PLXND1 and rs10245353 in NFE2L3 (show NFE2L3 Proteins) were associated with GDM.

  3. Authors found that the PlexinD1 cleavage product binds to actin rods, pathological aggregate-like structures which had so far been described for age-related neurodegenerative diseases. Data suggest a novel disease mechanism for SMA involving formation of actin rods as a molecular sink for a cleaved PlexinD1 fragment leading to dysregulation of receptor signaling.

  4. Measuring electrical impedance allows real-time monitoring of changes in endothelial cell morphology and adhesion induced by SEMA3E (show SEMA3E Proteins) via plexin D1

  5. Plexin D1 plays a role in collagen contraction in human lung fibroblasts.

  6. Findings suggest that Plexin-D1/class III semaphorin (Sema3E (show SEMA3E Proteins)) axis is triggered in systemic sclerosis (SSc (show CYP11A1 Proteins)) endothelium.

  7. finding that PLXND1 and REV3L mutations are responsible for a proportion of MBS (show PPP1R12A Proteins) patients suggests that de novo mutations in other genes might account for other MBS (show PPP1R12A Proteins) patients

  8. The data indicate that Plexin-D1 operates in a cell context-specific fashion, mediating different synaptogenic outcomes depending upon neuron type.

  9. Plxnd1 is a novel regulator of VAT growth, body fat distribution, and insulin (show INS Proteins) sensitivity in both zebrafish and humans

  10. The identification and characterization of SH3BP1 (show SH3BP1 Proteins) as a novel downstream effector of Sema3E (show SEMA3E Proteins)-PlexinD1 provides an explanation for how extracellular signals are translated into cytoskeletal changes and unique cell behavior.

Mouse (Murine) Plexin D1 (PLXND1) interaction partners

  1. Authors found that the PlexinD1 cleavage product binds to actin rods, pathological aggregate-like structures which had so far been described for age-related neurodegenerative diseases. Data suggest a novel disease mechanism for SMA involving formation of actin rods as a molecular sink for a cleaved PlexinD1 fragment leading to dysregulation of receptor signaling.

  2. GIPC1 (show GIPC1 Proteins) forms a domain-swapped dimer in an autoinhibited conformation that hinders binding of both PlexinD1 and myosin VI (show MYO6 Proteins). PlexinD1 binding to GIPC1 (show GIPC1 Proteins) releases the autoinhibition, promoting its interaction with myosin VI (show MYO6 Proteins). GIPCs and myosin VI (show MYO6 Proteins) interact through two distinct interfaces and form an open-ended alternating array.

  3. Sema3G (show SEMA3G Proteins) induces cell collapse in an Nrp2 (show NRP2 Proteins)/PlexinD1-dependent manner.

  4. Our results demonstrate that sema3e (show SEMA3E Proteins)/plexin D1 modulates IS formation and Ag-scanning activities of thymocytes within thymic tissues.

  5. Sema3E (show SEMA3E Proteins)/PlexinD1 signaling controls the motogenic potential of Cajal-Retzius (CR) cells in vitro and in vivo. Absence of Sema3E (show SEMA3E Proteins)/PlexinD1 signalling increased the migratory properties of CR cells.

  6. Sema3E (show SEMA3E Proteins)-PlexinD1 signaling is involved in the development of CNV. Stimulation of the pathway has therapeutic potential for CNV.

  7. Proprioceptive sensory afferents that express PlexinD1 avoid forming monosynaptic connections with neurons in Sema3E (show SEMA3E Proteins)(+) motor pools yet are able to form direct connections with neurons in Sema3E (show SEMA3E Proteins)(off) motor pools.

  8. beta1 integrin adhesion is controlled by the plexinD1-sema3E (show SEMA3E Proteins) axis in mice

  9. Data an association between Plexin-B2 (show PLXNB2 Proteins) and Plexin-D1 with the negative regulation of IL-12 (show IL12A Proteins)/IL-23p40 in DCs.

  10. This study demonstrated that Sema3E (show SEMA3E Proteins) and Plexin-D1 specify the degree of glutamatergic connectivity between a specific source and target in the complex circuitry of the basal ganglia.

Zebrafish Plexin D1 (PLXND1) interaction partners

  1. Sema3d (show SEMA3D Proteins) regulates collective endothelial cell migration in zebrafish through two separate mechanisms. Mesenchymal Sema3d (show SEMA3D Proteins) guides outgrowth of the common cardinal (show CARD8 Proteins) vein via repulsion and signals through PlexinD1.

  2. Plxnd1 is a novel regulator of VAT growth, body fat distribution, and insulin (show INS Proteins) sensitivity in both zebrafish and humans

  3. Somite expression of known vascular guidance cues, efnb2, sema3a2, and plexinD1 are disrupted, suggesting that the inter-somitic vessel vascular phenotype is due to disruption of these cues.

  4. We show that proper blood vessel pathfinding requires the endothelial receptor PlexinD1 and semaphorin signals, and we identify mutations in plexinD1 in the zebrafish vascular patterning mutant out of bounds

  5. Loss of plxnB2 (show PLXNB2 Proteins) results in delayed ISV sprouting identical to that seen in sema3e (show SEMA3A Proteins) morphants, while loss of plexinD1 in out of bounds (obd) mutants results in precocious ISV sprouting.

Plexin D1 (PLXND1) Protein Profile

Protein Summary

Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Mediates anti-angiogenic signaling in response to SEMA3E. Required for normal development of the heart and vasculature.

Gene names and symbols associated with Plexin D1 Proteins (PLXND1)

  • plexin D1 (PLXND1)
  • plexin D1 (Plxnd1)
  • plexin D1 (plxnd1)
  • plexin-D1 (LOC100409974)
  • 6230425C21Rik protein
  • b2b553Clo protein
  • plexd1 protein
  • zgc:77379 protein

Protein level used designations for Plexin D1 Proteins (PLXND1)

plexin-D1 , obd , out of bounds , plexin D1 , plexin-D1-like , LOW QUALITY PROTEIN: plexin-D1

GENE ID SPECIES
23129 Homo sapiens
67784 Mus musculus
312652 Rattus norvegicus
402998 Danio rerio
416124 Gallus gallus
460687 Pan troglodytes
476526 Canis lupus familiaris
779491 Xenopus (Silurana) tropicalis
781625 Bos taurus
100409974 Callithrix jacchus
100451917 Pongo abelii
100483438 Ailuropoda melanoleuca
100545536 Meleagris gallopavo
100595621 Nomascus leucogenys
100152254 Sus scrofa
100716223 Cavia porcellus
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