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PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001 [PubMed 11287196]). Additionally we are shipping PCGF1 Antibodies (51) and PCGF1 Kits (7) and many more products for this protein.
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The results of the present study demonstrated that miR320a inhibition decreased insulininduced KGN cell proliferation and apoptosis by targeting PCGF1.
these results demonstrate that NSPc1 promotes cancer stem cell self-renewal by repressing the synthesis of all-trans retinoic acid via targeting RDH16 and may provide novel targets for glioma treatment in the future.
knockdown of PCGF1 results in reduced expression of DPPA4 and other subunits of the variant PRC1 complex at both mRNA and protein levels. Thus, PCGF1 represents a physical and functional link between Polycomb function and pluripotency
polycomb has a role in stem cell fate and development of cancer (review)
Pcgf1 positively regulated expression of essential transcription factors involved in ectoderm and mesoderm differentiation, revealing an unexpected function of Pcgf1 in gene activation during ES cell lineage specification.
Nspc1 has a positive role in maintaining the pluripotency of P19 cells by directly regulating Oct4.
Pcgf1 is an epigenetic regulator of hematopoietic cell differentiation. Simultaneous depletion of Runx1 and Pcgf1 allows sustained self-renewal while blocking differentiation of lineage marker-negative cells in vitro.
Pcgf1 is involved in cell proliferation during early embryogenesis and establishes a link between epigenetics and aging.
Nspc1 was expressed globally at the early stage.
PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001
polycomb group ring finger 1
, polycomb group RING finger protein 1
, RING finger protein 68
, nervous system Polycomb-1
, nervous system polycomb 1
, RING finger