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Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. Additionally we are shipping Polyhomeotic Homolog 3 (Drosophila) Proteins (3) and many more products for this protein.
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Human Polyclonal PHC3 Primary Antibody for ICC, IF - ABIN4345165
Choi, Kim, Cho, Lee, Yi, Eun, Kim, Woo, Choi, Whangbo, Choi, Noh, Moon: Noninvasive identification of viable cell populations in docetaxel-treated breast tumors using ferritin-based magnetic resonance imaging. in PLoS ONE 2013
Data show that polycomb-group proteins BMI1, PHC3, CBX6 and CBX7 expression was significantly increased during imatinib treatment.
PHC3 amplification may emerge as a biomarker in cancer.
SAM linker controls PHC3 SAM polymerization
PHC3 is a tumor suppressor in osteosarcoma cells abd its suppression may be caused by modification of polycomb repressive complex 1 in cancer cells.
loss of PHC3 may favor tumorigenesis by potentially disrupting the ability of cells to remain in G(0)
Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones\; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity).
polyhomeotic-like protein 3
, polyhomeotic like 3
, polyhomeotic homolog 3 (Drosophila)
, early development regulator 3
, early development regulatory protein 3
, homolog of polyhomeotic 3
, polyhomeotic 3