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Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. Additionally we are shipping Potassium Channel, Subfamily K, Member 4 Antibodies (18) and many more products for this protein.
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Functional alanine-mutagenesis screens of TASK-1 (show KCNK3 Proteins) and TRAAK were used to build an in silico model of the TASK-1 (show KCNK3 Proteins) cap.
KCNK4 promoter methylation is associated with Breast Cancer.
How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1 (show KCNK2 Proteins), and TREK2 (show KCNK10 Proteins).
findings uncover a unique aspect of potassium channel (show KCNAB2 Proteins) modulation, indicate a means for how the channel C-terminal cytoplasmic domain affects the C-type gate, and suggest how lipids and bilayer inner leaflet deformations gate the channel.
TRAAK is responsive to mechanical forces similar to the ion channel Piezo1 (show PIEZO1 Proteins); mechanical activation of TRAAK can electrically counter Piezo1 (show PIEZO1 Proteins) activation.
crystal structure of TRAAK at 3.8 angstroms resolution; channel comprises 2 protomers that create 2-fold symmetric K(+) channel (show KCNC4 Proteins); extracellular surface has a helical cap; 2 diagonally opposed gate-forming inner helices form membrane-interacting structures
role for TREK-1 (show KCNK2 Proteins) in contributing to uterine quiescence during gestation
Human TASK-3 (show KCNK9 Proteins) was cloned and expressed; protein sequence and activity compared to similar two pore domain potassium channels, including KCNK4 (TRAAK).
Hyperoxia treatment of TREK-1/TREK (show KCNK2 Proteins)-2 (show KCNK10 Proteins)/TRAAK-deficient mice is associated with a reduction in surfactant proteins
The beneficial effects of TRAAK deletion designate this channel as a promising pharmacological target for the treatment against stroke.
The TRAAK appears to be strongly involved in regulating airway mechanosensing since it was found to be expressed on the terminals of all subpopulations of potential vagal mechanosensors.
TREK-1 (show KCNK2 Proteins), TREK-2 (show KCNK10 Proteins), and TRAAK are lysophosphatidic acid-operated K+ channels
primary observation is that the mechanosensitive K2P channels TREK-1 and TRAAK desensitize; desensitization and its regulation by chemical messengers is predicted to condition the physiological role of K2P channels
Together TREK-1 (show KCNK2 Proteins) and TRAAK channels are important regulators of nociceptor activation by cold, particularly in the nociceptor population that is not activated by menthol.
Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The encoded protein homodimerizes and functions as an outwardly rectifying channel. It is expressed primarily in neural tissues and is stimulated by membrane stretch and polyunsaturated fatty acids.
K2P4.1 potassium channel
, TWIK-related arachidonic acid-stimulated potassium channel protein
, potassium channel subfamily K member 4
, two pore K(+) channel KT4.1
, two pore K+ channel KT4.1
, two pore potassium channel KT4.1
, protein expressed in male leptotene and zygotene spermatocytes 622
, potassium inwardly-rectifying channel subfamily K member 4
, potassium inwardly-rectifying channel, subfamily K, member 4