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MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. Additionally we are shipping KCNMB4 Antibodies (49) and many more products for this protein.
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Two recurrent fusion genes associated with the 12q locus, LRP1-SNRNP25 and KCNMB4-CCND3, were by RT-PCR, Sanger sequencing and FISH, and were found to be osteosarcoma specific in a validation cohort of 240 other sarcomas.
Recombinant martentoxin selectively blocks KCNMA1/KCNMB4 channels.
BK channel beta4 subunit influences sensitivity and tolerance to alcohol by altering its response to kinases
Study shows that beta4 subunit of the MaxiK channel has no potential endocytic signal and 2 specific amino acids in the functional basic motif retention/retrieval trafficking signal at the C-terminus may play a role in controlling cellular excitability
IFN-gamma changed mRNA levels of the BK beta-modulatory proteins KCNMB2 (increased) and KCNMB4 (decreased) as well as leucine-rich repeat-containing protein (LRRC)26 (decreased).
our data suggest that the rs398702 variant in the KCNMB4 gene is unlikely to influence significantly the risk of developing mesial temporal lobe epilepsy or its severity
These results suggest that fast-gating, type I BK channels lacking beta4 can increase neuronal excitability in response to reduced phosphatase activity and activation of calcium channels.
Structural basis for toxin resistance of beta4-associated calcium-activated potassium (BK) channels
The beta4 subunit controls ethanol tolerance at the molecular, cellular, and behavioral levels, and could determine individual differences in alcohol abuse and alcoholism, as well as represent a therapeutic target for alcoholism.
Report beta subunit (KNMB1-4)-specific modulations of BK channel function by a Slo1 mutation associated with epilepsy and dyskinesia.
results argue that, for native mouse Slo3 channels, the beta4 subunit must be considered as a potential interaction partner and, furthermore, that KCNMB subunits may have functions unrelated to regulation of the Slo1 alpha subunit
conclude that seizure-induced downregulation of KCNMB4 is an activity dependent mechanism that increases the excitability of DG neurons. These novel findings indicate that BK channel subtypes are not only defined by cell-specific expression, but can also be plastic depending on the recent history of neuronal excitability
These results indicate that an important role of the beta4-subunit is to reduce ryanodine receptor-BK channel functional coupling during the afterhyperpolarization component of the action potential, thereby decreasing excitability of dentate gyrus neurons.
the enhanced effect of amiloride on potassium secretion in wild-type compared to knockout mice on the alkaline diet clarify a BK- alpha/beta4-mediated potassium secretory pathway in intercalated cells driven by ENaC-mediated sodium reabsorption
BKbeta4 expression in astrocytes likely participates in regulating astrocytic voltage gradients and maintaining potassium homeostasis, hence enabling astrocytes to fulfill their complex regulatory influence on proper brain function.
E2 at physiological concentrations augments K(Ca) currents through ERbeta in the GT1-7 GnRH neuronal cell line and increases the expression of the BK channel subunit mRNAs, alpha and beta4
The study verified that the BK(Ca) channel alpha-subunit is located to smooth muscle cells of porcine basilar and middle cerebral arteries.
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit.
BK channel subunit beta-4
, calcium activated potassium channel beta 4 subunit
, calcium-activated potassium channel subunit beta-4
, calcium-activated potassium channel, subfamily M subunit beta-4
, charybdotoxin receptor subunit beta-4
, maxi K channel subunit beta-4
, large conductance calcium-dependent potassium ion channel beta 4 subunit
, Slowpoke beta 4
, calcium-activated potassium channel beta 4 subunit
, potassium large conductance calcium-activated channel, subfamily M, beta member 4
, large calcium-activated potassium channel subfamily M beta member 4