Melanoma gp100 Proteins

Protein Summary

This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with Premelanosome Protein Proteins (PMEL)

• premelanosome protein (PMEL) antibody
• premelanosome protein (Pmel) antibody
• premelanosome protein a (pmela) antibody

• cb397 antibody
• D10H12S53E antibody
• D12S53E antibody
• D12S53Eh antibody
• fdv antibody
• Show all synonym aliases
• gp87 antibody
• gp100 antibody
• ME20 antibody
• ME20-M antibody
• ME20M antibody
• MMP115 antibody
• P1 antibody
• P100 antibody
• pmel17 antibody
• RPE1 antibody
• sb:cb397 antibody
• Si antibody
• SIL antibody
• Silv antibody
• silva antibody
• silver antibody
• wu:fc11g11 antibody
• wu:fj24g11 antibody
• zgc:136622 antibody

Protein level used designations for Premelanosome Protein Proteins (PMEL)

melanocyte protein PMEL , melanocyte protein Pmel 17 , melanocyte protein mel 17 , melanocytes lineage-specific antigen GP100 , melanoma-associated ME20 antigen , melanosomal matrix protein17 , silver locus protein homolog , silver, mouse, homolog of , melanocyte protein pmel 17 , silver locus protein , retinal pigment epithelial-specific protein , silver homolog , 115 kDa melanosomal matrix protein , PMEL17 protein , melanocyte protein 17 , premelanosomal protein , fading vision , melanosomal matrix protein , silver homolog a