anti-Probable Fructose-2,6-Bisphosphatase TIGAR (TIGAR) Antibodies

is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate.

list all antibodies Gene Name GeneID UniProt
Anti-Mouse  319801 Q8BZA9
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Top anti-Probable Fructose-2,6-Bisphosphatase TIGAR (TIGAR) Antibodies at antibodies-online.com

Showing 10 out of 109 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Anti-C12orf5 / TIGAR antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN960902 concentration 10 ug/ml. 50 μg Log in to see 7 to 9 Days
$484.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 7 to 9 Days
$507.83
Details
Dog Rabbit Un-conjugated IHC, IHC (p), WB Anti-C12orf5 / TIGAR antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN960901 concentration 10 ug/ml. 50 μg Log in to see 7 to 9 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB   0.1 mg Log in to see 8 to 11 Days
$474.10
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB   0.1 mg Log in to see 8 to 11 Days
$474.10
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Human Breast (formalin-fixed, paraffin-embedded) stained with C12orf5 antibody ABIN213914 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with C12orf5 antibody ABIN214419 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
$484.00
Details
Mouse Rabbit Un-conjugated WB TIGAR Antibody (N-term)  western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the TIGAR antibody detected the TIGAR protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western Blot: TIGAR/C12orf5 Antibody  - Sample (30 ug of whole cell lysate) A: Raji 12% SDS PAGE gel, diluted at 1:2000. 0.1 mL Log in to see 8 to 11 Days
$514.63
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse intestine labeled with Rabbit Anti TIGAR Polyclonal Antibody, Unconjugated (ABIN671286) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded mouse lung labeled with Rabbit Anti TIGAR Polyclonal Antibody, Unconjugated (ABIN671286) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$306.90
Details

Top referenced anti-Probable Fructose-2,6-Bisphosphatase TIGAR (TIGAR) Antibodies

  1. Human Polyclonal Primary Antibody for IHC, ELISA - ABIN1003279 : Corcoran, Huang, Sheikh: The regulation of energy generating metabolic pathways by p53. in Cancer biology & therapy 2007 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal Primary Antibody for IHC, ELISA - ABIN1003280 : Bensaad, Tsuruta, Selak, Vidal, Nakano, Bartrons, Gottlieb, Vousden: TIGAR, a p53-inducible regulator of glycolysis and apoptosis. in Cell 2006 (PubMed)
    Show all 3 Pubmed References

More Antibodies against Probable Fructose-2,6-Bisphosphatase TIGAR (TIGAR) Interaction Partners

Mouse (Murine) Probable Fructose-2,6-Bisphosphatase TIGAR (TIGAR) interaction partners

  1. TIGAR contributes to ischemic tolerance induced by cerebral preconditioning through scavenging of reactive oxygen species and inhibition of apoptosis.

  2. Results suggest that TIGAR expression changes during development and its expression level may be correlated with the vulnerability of neurons to ischemic injury.

  3. Although mouse TIGAR expression is clearly induced in the intestines of mice following DNA-damaging stress of ionizing radiation, that was not dependent on p53 (show TP53 Antibodies) or TAp73 (show TP73 Antibodies).

  4. TIGAR protein expression in brain is increased following ischemia reperfusion injury.

  5. Therefore, we conclude that TIGAR knockdown-induced radiosensitization of glioma cells may be dependent on the inhibition of TRX1 (show TXN Antibodies) nuclear translocation.

  6. TIGAR protects ischemic brain injury and preserves mitochodrial function.

  7. TIGAR has roles in efficient intestinal regeneration and tumorigenesis

  8. p53/TIGAR-mediated inhibition of myocyte mitophagy is responsible for impairment of mitochondrial integrity and subsequent apoptosis.

  9. p53 and TIGAR inhibit glycolysis in hypoxic myocytes and that inhibition of glycolysis is closely involved in apoptosis, suggesting that p53 and TIGAR are significant mediators of cellular energy homeostasis and cell death under ischemic stress.

Probable Fructose-2,6-Bisphosphatase TIGAR (TIGAR) Antigen Profile

Protein Summary

This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region.

Gene names and symbols associated with

  • Trp53 induced glycolysis repulatory phosphatase (Tigar) antibody
  • AA793651 antibody
  • AI595337 antibody
  • C79710 antibody
  • C85509 antibody
  • Tigar antibody

Protein level used designations for

TP53-induced glycolysis and apoptosis regulator , fructose-2,6-bisphosphatase TIGAR , probable fructose-2,6-bisphosphatase TIGAR

GENE ID SPECIES
319801 Mus musculus
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