Proline-serine-threonine Phosphatase Interacting Protein 1 Proteins (PSTPIP1)

The protein encoded by PSTPIP1 binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. Additionally we are shipping PSTPIP1 Antibodies (50) and PSTPIP1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PSTPIP1 9051 O43586
PSTPIP1 19200 P97814
Rat PSTPIP1 PSTPIP1 300732  
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Top PSTPIP1 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 13 to 16 Days
$400.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$547.80
Details

PSTPIP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

More Proteins for Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1) Interaction Partners

Human Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1) interaction partners

  1. We identified HPIP protein expression as a novel independent poor prognostic indicator in cervical cancer

  2. Case Report: classical pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome with E250K mutation of PSTPIP1.

  3. HPIP expression is associated with high-grade ovarian tumors.

  4. we demonstrated that HPIP silencing suppressed TGF-beta1-induced EMT in lung cancer cells by inhibiting Smad2 activation.

  5. our study demonstrated that knockdown of HPIP significantly inhibits the proliferation and migration/invasion of HNSCC cells by suppressing the PI3K/Akt signaling pathway.

  6. these structural variations in CD2BP1 gene due to the mutations could be one of the strongest reasons to demonstrate the involvement of these gene variations in the patients with rheumatoid arthritis.

  7. PSTPIP1 was found to interact with pyrin at the leading edge during cell migration.

  8. genetic polymorphism is associated with hyperzincemia and hypercalprotectinemia

  9. Molecular interactions between HPIP and FAK, and HPIP and calpain2 regulate cell adhesion and migration through modulation of focal adhesion dynamics.

  10. Case Report: missense mutation in PSTPIP1, the gene responsible for PAPA syndrome.

  11. we have shown that PSTPIP1 regulates T-cell activation upon CD3 and CD28 stimulation, independently of CD2 costimulation. PSTPIP1 acts downstream of proximal TCR signaling, inhibiting several transcription factors.

  12. PSTPIP1 has a role in the pathogenesis of pyoderma gangrenosum through filopodia formation resulting in extracellular matrix degradation

  13. novel mutaations found in PSTPIP1 gene in patients with pyoderma gangrenosum

  14. non-mutated gene and pyoderma gangrenosum in IBD unresponsive to anakinra treatment

  15. The CCTG repeat in the PSTPIP1 promoter may play a role in the pathogenesis of aseptic abscess syndrome and Crohn's disease.

  16. CD2BP1-mediated biochemical pathway(s) may function in common inflammatory disorders with apparent etiological overlap, such as rheumatoid arthritis and inflammatory bowel disease

  17. PSTPIP1 acts downstream of CD2/CD2AP to link CD2 engagement to the WASp-evoked actin polymerization required for synapse formation and T cell activation.

  18. PSTPIP1/CD2BP1 protein binds to pyrin

  19. the intracellular Fas ligand (FasL) domain binding to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL

  20. CD2BP1 directly and negatively impacts T cell activation via isolated CD2 antigen triggering or T-cell receptor stimulation dependent on coordinate CD2 engagement.

Mouse (Murine) Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1) interaction partners

  1. a new PSTPIP1/PTPN6/SHIP1/2-dependent negative feedback mechanism that counterbalances Src and PI(3,4,5)P3 signalling to control osteoclast cell polarity and activity during bone resorption

  2. analysis of inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins

  3. the intracellular Fas ligand (FasL) domain binding to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL

  4. PSTPIP1 is a novel component of the leukocyte uropod that regulates endocytosis and cell migration

PSTPIP1 Protein Profile

Protein Summary

The protein encoded by this gene binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. The encoded protein appears to be a scaffold protein and a regulator of the actin cytoskeleton. It has also been shown to bind ABL1, PTPN18, WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPA syndrome.

Gene names and symbols associated with PSTPIP1

  • proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1)
  • proline-serine-threonine phosphatase interacting protein 1 S homeolog (pstpip1.S)
  • proline-serine-threonine phosphatase interacting protein 1 (pstpip1)
  • proline-serine-threonine phosphatase-interacting protein 1 (Pstpip1)
  • CD2BP1 protein
  • CD2BP1L protein
  • CD2BP1S protein
  • def-2 protein
  • H-PIP protein
  • PAPAS protein
  • PSTPIP protein
  • PSTPIP1 protein

Protein level used designations for PSTPIP1

proline-serine-threonine phosphatase interacting protein 1 , proline-serine-threonine phosphatase-interacting protein 1 , CD2 antigen-binding protein 1 , CD2 cytoplasmic tail-binding protein , CD2-binding protein 1 , PEST phosphatase-interacting protein 1

GENE ID SPECIES
415349 Gallus gallus
447609 Xenopus laevis
513924 Bos taurus
100050881 Equus caballus
100152628 Sus scrofa
100379705 Xenopus (Silurana) tropicalis
9051 Homo sapiens
19200 Mus musculus
300732 Rattus norvegicus
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