Prostaglandin D2 Synthase 21kDa (Brain) Proteins (PTGDS)

The protein encoded by PTGDS is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2).

list all proteins Gene Name GeneID UniProt
Human PTGDS PTGDS 5730 P41222
Mouse PTGDS PTGDS 19215 O09114
Rat PTGDS PTGDS 25526 P22057
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Top PTGDS Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Mammalian Cells Human His tag   50 μg Log in to see 4 Days
$385.00
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Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$688.00
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Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,370.50
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,377.83
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Yeast Wild boar His tag   1 mg Log in to see 60 to 71 Days
$2,377.83
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Yeast REACT_Bear His tag   1 mg Log in to see 60 to 71 Days
$2,383.33
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Yeast Sheep His tag   1 mg Log in to see 60 to 71 Days
$2,383.33
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Yeast Dog His tag   1 mg Log in to see 60 to 71 Days
$2,383.33
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Yeast Cat His tag   1 mg Log in to see 60 to 71 Days
$2,383.33
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Yeast Pongo pygmaeus His tag   1 mg Log in to see 60 to 71 Days
$2,387.00
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More Proteins for Prostaglandin D2 Synthase 21kDa (Brain) (PTGDS) Interaction Partners

Human Prostaglandin D2 Synthase 21kDa (Brain) (PTGDS) interaction partners

  1. Thus, our results suggest decreased NK cell-mediated eosinophil regulation, possibly through an increased level of PGD2, as a previously unrecognized link between PG dysregulation and eosinophilic inflammation in CRS (show CARS Proteins).

  2. These observations suggest that tumor cell-derived inflammatory cytokines increase L-PGDS expression and subsequent PGD2 production in the tumor endothelial cells (ECs). This PGD2 acts as a negative regulator of the tumorigenic changes in tumor ECs.

  3. Serum levels of beta trace protein and beta 2 microglobulin (show B2M Proteins) can be used to predict residual kidney function in hemodialysis patients.

  4. BTP and B2M (show B2M Proteins) levels are less affected than serum by amputation, and should be considered for future study of GFR (show RAPGEF5 Proteins) estimation

  5. Hematopoietic prostaglandin D synthase (show HPGDS Proteins) defines a proeosinophilic pathogenic effector human T(H)2 cell subpopulation with enhanced function

  6. levels of L-PGDS in cervicovaginal secretions of pregnant women at different stages of parturition correlate with preterm birth.

  7. PTGDS mRNA expression was down-regulated in rapid-cycling bipolar disorder patients in a euthymic, depressive, and manic/hypomanic state compared with healthy control subjects.

  8. Expression of MR and prostaglandin D2 synthase is strongly correlated in adipose tissues from obese patients.

  9. These data indicate that scalp is spatially programmed via mast cell prostaglandin D-synthase distribution in a manner reminiscent of the pattern seen in androgenetic alopecia.

  10. These results suggest that L-PGDS acted as a scavenger of biliverdin, which is a molecule not found in normal CSF (show CSF2 Proteins).

Mouse (Murine) Prostaglandin D2 Synthase 21kDa (Brain) (PTGDS) interaction partners

  1. These observations suggest that tumor cell-derived inflammatory cytokines increase L-PGDS expression and subsequent PGD2 production in the tumor endothelial cells (ECs). This PGD2 acts as a negative regulator of the tumorigenic changes in tumor ECs.

  2. Exposure of macrophages to cyclooxygenase (COX-2) inhibitors RhoA (show RHOA Proteins) and LA-4 cells to antagonists of prostaglandin E2 (PGE2) receptor , PGD2 receptors or the hepatocyte growth factor (HGF (show HGF Proteins)) receptor c-Met (PHA (show LBR Proteins)-665752), reversed EMT (show ITK Proteins) inhibition by the conditioned medium

  3. Ptgds is targeted and repressed by the CUL4B (show CUL4B Proteins)/PRC2 complex.

  4. Thermodynamic and nuclear magnetic resonance analyses demonstrated that L-PGDS binds to nicotinamide coenzymes, including NADPH, NADP(+), and NADH.

  5. Prostaglandin D2 synthase is a novel MR target gene in adipocytes.

  6. When prostaglandin D2 synthase is upregulated it participates in the regulation of peripheral nervous system myelination.

  7. expression of L-PGDS in mouse lungs decreased neutrophilic infiltration, ameliorating lung inflammation in mice.

  8. Silencing of PTGDS also alleviated H-rev107 (show HRASLS Proteins)-mediated suppression of cell migration and invasion

  9. In this report, we show for the first time that alteration of the PTGDS-governed PGD2 pathway disturbs testicular migration in mice.

  10. Data indicate a PLA2G3 (show PLA2G3 Proteins)-lipocalin (show APOD Proteins)-type PGD2 synthase (L-PGDS)-PGD2 receptor DP1 (show PTGDR Proteins) loop that drives mast cell maturation.

Cow (Bovine) Prostaglandin D2 Synthase 21kDa (Brain) (PTGDS) interaction partners

  1. L-PGDS may have a role in cattle fertilization.

PTGDS Protein Profile

Protein Summary

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep.

Gene names and symbols associated with PTGDS

  • prostaglandin D2 synthase (PTGDS)
  • lipocalin 15 (lcn15)
  • hematopoietic prostaglandin D synthase (HPGDS)
  • prostaglandin D2 synthase 21kDa (brain) (PTGDS)
  • prostaglandin D2 synthase L homeolog (ptgds.L)
  • prostaglandin D2 synthase (brain) (Ptgds)
  • prostaglandin D2 synthase (Ptgds)
  • 21kDa protein
  • cerebrin-28 protein
  • cpl-1 protein
  • l-pgds protein
  • lpgds protein
  • pds protein
  • pgd2 protein
  • pgds protein
  • pgds2 protein
  • PH2DISO protein
  • PTGDS protein
  • Ptgs3 protein
  • XlCpl1 protein
  • zgc:153919 protein

Protein level used designations for PTGDS

PGD2 synthase , beta-trace protein , cerebrin-28 , glutathione-independent PGD synthase , glutathione-independent PGD synthetase , lipocalin-type prostaglandin D synthase , lipocalin-type prostaglandin-D synthase , prostaglandin D synthase , prostaglandin-D2 synthase , prostaglandin-H2 D-isomerase , prostaglandin D2 synthase, hematopoietic , prostaglandin D2 synthase 21kDa (brain) , Prostaglandin D Synthase , lipocalin , prostaglandin D2 synthase, brain , GST class-sigma , H-PGDS , glutathione S-transferase , glutathione-dependent PGD synthase , glutathione-dependent PGD synthetase , glutathione-requiring prostaglandin D synthase , prostaglandin-D synthase , prostaglandin D2 synthase (21 kDa, brain) , PGDS , PGDS2 , Prostaglandin D synthase , lipocalin-type prostaglandin D2 synthase

GENE ID SPECIES
5730 Homo sapiens
751703 Danio rerio
705227 Macaca mulatta
100353701 Oryctolagus cuniculus
749402 Pan troglodytes
397884 Xenopus laevis
395863 Gallus gallus
19215 Mus musculus
25526 Rattus norvegicus
403740 Canis lupus familiaris
493852 Felis catus
100067921 Equus caballus
397456 Sus scrofa
286858 Bos taurus
443192 Ovis aries
101926100 Macaca fascicularis
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