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PROC encodes a vitamin K-dependent plasma glycoprotein. Additionally we are shipping PROC Kits (22) and PROC Proteins (21) and many more products for this protein.
Showing 10 out of 35 products:
Human Polyclonal PROC Primary Antibody for IHC (p), WB - ABIN3044486
Liu, An, Liu, Li, Tang, Chen: Mouse lung slices: An ex vivo model for the evaluation of antiviral and anti-inflammatory agents against influenza viruses. in Antiviral research 2015
Show all 10 Pubmed References
Data show that activated protein C signals via protease activated receptors PAR2 (show F2RL1 Antibodies)/PAR3 (show F2RL2 Antibodies) to expand Treg cells, mitigating the disease in mice.
insulin (show INS Antibodies) and aPC (show APC Antibodies) converge on a common spliced-X-box binding protein-1 (show XBP1 Antibodies) (sXBP1) signaling pathway to maintain endoplasmic reticulum (ER) homeostasis.
loss of the convertase furin (show FURIN Antibodies) or PC5 (show PCSK5 Antibodies)/6 in hepatocytes results in a approximately 30% decrease in APC (show APC Antibodies) levels, with no significant contribution from PACE4 (show PCSK6 Antibodies). We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin (show F2 Antibodies) activation.
APC (show APC Antibodies) modifies pulmonary fibrosis by limiting thrombin (show F2 Antibodies)-dependent macrophage recruitment.
Small interfering RNA-mediated silencing of protein C in apolipoprotein E (show APOE Antibodies)-deficient mice creates a condition that allows the occurrence of spontaneous atherothrombosis.
These findings reveal a novel biological function and mechanism of the protein C pathway in which protein S and the aPC (show APC Antibodies)-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC (show APC Antibodies) in the context of endotoxemia and infection
activated PC-EPCR-PAR1 signaling promotes hematopoietic stem cell retention in bone marrow.
impaired EPCR (show PROCR Antibodies)/protein C-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis
SOD prevents thrombomodulin (show THBD Antibodies) methionine oxidation, promotes protein C activation, and protects against arterial and venous thrombosis in mice.
sPLA2 (show PLA2G2A Antibodies)-V plays a thrombogenic role by impairing the ability of EPCR (show PROCR Antibodies) to promote protein C activation.
We recently identified a venous thrombosis patient whose plasma level of protein C antigen is normal, but its anticoagulant activity is only 34 % of the normal level. Genetic analysis revealed that the proband and her younger brother carry a novel heterozygous mutation c.346G>A, p.Gly74Ser (G74S) in PROC.
Developed functional protein S assays that measure both the activated protein C- and TFPI (show TFPI Antibodies)-cofactor activities of protein S in plasma, which are hardly if at all affected by the FV Leiden mutation.
Protein C seems inversely associated with mortality in patients with advanced prostate, lung and pancreatic cancer. Further research should validate protein C as a biomarker for mortality, and explore the effects of protein C on progression of cancer.
Genetically higher protein C was associated with a lower risk of ischaemic heart disease.
EPCR (show PROCR Antibodies) occupancy recruits G-protein coupled receptor kinase 5 (show GRK5 Antibodies), thereby inducing beta-arrestin-2 (show ARRB2 Antibodies) biased PAR1 (show MARK2 Antibodies) signaling by both APC (show APC Antibodies) and thrombin (show F2 Antibodies). In
A novel mutation of A309V in PROC was determined in a family of two patients with late onset protein C deficiency
Both probands had hereditary protein C deficiencies, for which their parents were all carriers.
Variants influencing circulating protein C levels in the CELSR2 (show CELSR2 Antibodies)-PSRC1 (show PSRC1 Antibodies)-SORT1 (show SORT1 Antibodies) region may indicate a novel genetic link between lipoprotein metabolism and hemostasis.
These findings suggest that the anti-inflammatory function of APC (show APC Antibodies) at therapeutic concentrations may include the inhibition of NETosis in an EPCR (show PROCR Antibodies)-, PAR3 (show F2RL2 Antibodies)-, and Mac-1 (show ITGAM Antibodies)-dependent manner, providing additional mechanistic insight into the diverse functions of neutrophils and APC (show APC Antibodies) in disease states including sepsis.
Activated protein c is a ghrelin (show GHRL Antibodies) endopeptidase.
Activated protein C(APC (show APC Antibodies)) combined with protein S(PS) had significant antithrombotic effect. APC (show APC Antibodies) combined with PS prolonged clotting time. Dependence on APC (show APC Antibodies)-cofactor activity of PS for expression of anticoagulant activity by APC (show APC Antibodies).
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
, anticoagulant protein C
, vitamin K-dependent protein C
, protein C (inactivator of coagulation factors Va and VIIIa)
, vitamin K-dependent protein C-like
, autoprothrombin IIA
, blood coagulation factor XIV
, inactivator of coagulation factors Va, VIII
, catalytic region
, protein C (precursor of vitamin K-dependent serine protease)