anti-Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) Antibodies

PROC encodes a vitamin K-dependent plasma glycoprotein.

list all antibodies Gene Name GeneID UniProt
Anti-Rat PROC PROC 25268 P31394
Anti-Mouse PROC PROC 19123 P33587
Anti-Human PROC PROC 5624 P04070
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Top anti-PROC Antibodies at antibodies-online.com

Showing 10 out of 42 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Horse Rabbit Un-conjugated IHC, WB WB Suggested Anti-PROC Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  MCF7 cell lysate Host:  Rabbit  Target Name:  PROC  Sample Type:  Human Adult Placenta  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-Protein C antibody, Western blotting Lane 1: JURKAT Cell Lysate Lane 2: CEM Cell Lysate Lane 3: SMMC Cell Lysate Lane 4: HELA Cell Lysate Anti-Protein C antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue 100 μg Log in to see 4 to 6 Days
$280.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PROC Antibody Titration:  2.5ug/ml  Positive Control:  Transfected 293T 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Confocal immunofluorescent analysis of PROC Antibody (Center) (ABIN657466) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Western Blot at 1:500-1:1000 dilution Lane 1: human liver lysate Lane 2: human plasma lysate Lysates/proteins at 20 ug per lane. Confocal immunofluorescent analysis of PROC Antibody with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). 400 μL Log in to see 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 16 Days
$334.02
Details
Human Mouse Un-conjugated IP, ELISA, WB PROC monoclonal antibody (M01), clone 3A10. Western Blot analysis of PROC expression in human liver. Immunoprecipitation of PROC transfected lysate using anti-PROC monoclonal antibody and Protein A Magnetic Bead , and immunoblotted with PROC MaxPab rabbit polyclonal antibody. 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated WB Western blot analysis on human plasma using anti-vitamin K-dependent protein C polyclonal antibody.        100 μL Log in to see 13 to 16 Days
$416.90
Details
Human Mouse Un-conjugated WB Western Blot analysis of PROC expression in transfected 293T cell line by PROC MaxPab polyclonal antibody.<br><br>Lane 1: PROC transfected lysate(50.71 KDa).<br>Lane 2: Non-transfected lysate.<br> 50 μL Log in to see 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
$446.88
Details

Top referenced anti-PROC Antibodies

  1. Human Polyclonal PROC Primary Antibody for IHC (p), WB - ABIN3044486 : Liu, An, Liu, Li, Tang, Chen: Mouse lung slices: An ex vivo model for the evaluation of antiviral and anti-inflammatory agents against influenza viruses. in Antiviral research 2015 (PubMed)
    Show all 10 Pubmed References

More Antibodies against PROC Interaction Partners

Mouse (Murine) Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) interaction partners

  1. Data show that activated protein C signals via protease activated receptors PAR2 (show F2RL1 Antibodies)/PAR3 (show F2RL2 Antibodies) to expand Treg cells, mitigating the disease in mice.

  2. insulin (show INS Antibodies) and aPC (show APC Antibodies) converge on a common spliced-X-box binding protein-1 (show XBP1 Antibodies) (sXBP1) signaling pathway to maintain endoplasmic reticulum (ER) homeostasis.

  3. loss of the convertase furin (show FURIN Antibodies) or PC5 (show PCSK5 Antibodies)/6 in hepatocytes results in a approximately 30% decrease in APC (show APC Antibodies) levels, with no significant contribution from PACE4 (show PCSK6 Antibodies). We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin (show F2 Antibodies) activation.

  4. APC (show APC Antibodies) modifies pulmonary fibrosis by limiting thrombin (show F2 Antibodies)-dependent macrophage recruitment.

  5. Small interfering RNA-mediated silencing of protein C in apolipoprotein E (show APOE Antibodies)-deficient mice creates a condition that allows the occurrence of spontaneous atherothrombosis.

  6. These findings reveal a novel biological function and mechanism of the protein C pathway in which protein S and the aPC (show APC Antibodies)-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC (show APC Antibodies) in the context of endotoxemia and infection

  7. activated PC-EPCR-PAR1 signaling promotes hematopoietic stem cell retention in bone marrow.

  8. impaired EPCR (show PROCR Antibodies)/protein C-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis

  9. SOD prevents thrombomodulin (show THBD Antibodies) methionine oxidation, promotes protein C activation, and protects against arterial and venous thrombosis in mice.

  10. sPLA2 (show PLA2G2A Antibodies)-V plays a thrombogenic role by impairing the ability of EPCR (show PROCR Antibodies) to promote protein C activation.

Human Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) interaction partners

  1. Using protein C-factor VII (show TH Antibodies) chimera demonstrate that APC (show APC Antibodies) light chain amino acid residues outside the EPCR (show PROCR Antibodies)-binding site enable cytoprotective PAR1 (show MARK2 Antibodies) signaling.

  2. We recently identified a venous thrombosis patient whose plasma level of protein C antigen is normal, but its anticoagulant activity is only 34 % of the normal level. Genetic analysis revealed that the proband and her younger brother carry a novel heterozygous mutation c.346G>A, p.Gly74Ser (G74S) in PROC.

  3. Developed functional protein S assays that measure both the activated protein C- and TFPI (show TFPI Antibodies)-cofactor activities of protein S in plasma, which are hardly if at all affected by the FV Leiden mutation.

  4. Protein C seems inversely associated with mortality in patients with advanced prostate, lung and pancreatic cancer. Further research should validate protein C as a biomarker for mortality, and explore the effects of protein C on progression of cancer.

  5. Genetically higher protein C was associated with a lower risk of ischaemic heart disease.

  6. EPCR (show PROCR Antibodies) occupancy recruits G-protein coupled receptor kinase 5 (show GRK5 Antibodies), thereby inducing beta-arrestin-2 (show ARRB2 Antibodies) biased PAR1 (show MARK2 Antibodies) signaling by both APC (show APC Antibodies) and thrombin (show F2 Antibodies). In

  7. A novel mutation of A309V in PROC was determined in a family of two patients with late onset protein C deficiency

  8. loss of the convertase furin (show FURIN Antibodies) or PC5 (show PCSK5 Antibodies)/6 in hepatocytes results in a approximately 30% decrease in APC (show APC Antibodies) levels, with no significant contribution from PACE4 (show PCSK6 Antibodies). We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin (show F2 Antibodies) activation.

  9. Both probands had hereditary protein C deficiencies, for which their parents were all carriers.

  10. Variants influencing circulating protein C levels in the CELSR2 (show CELSR2 Antibodies)-PSRC1 (show PSRC1 Antibodies)-SORT1 (show SORT1 Antibodies) region may indicate a novel genetic link between lipoprotein metabolism and hemostasis.

Cow (Bovine) Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) interaction partners

  1. Activated protein c is a ghrelin (show GHRL Antibodies) endopeptidase.

  2. Activated protein C(APC (show APC Antibodies)) combined with protein S(PS) had significant antithrombotic effect. APC (show APC Antibodies) combined with PS prolonged clotting time. Dependence on APC (show APC Antibodies)-cofactor activity of PS for expression of anticoagulant activity by APC (show APC Antibodies).

PROC Antigen Profile

Protein Summary

This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.

Gene names and symbols associated with PROC

  • protein C (inactivator of coagulation factors Va and VIIIa), a (proca) antibody
  • protein C, inactivator of coagulation factors Va and VIIIa (PROC) antibody
  • protein C (inactivator of coagulation factors Va and VIIIa) (PROC) antibody
  • protein C, inactivator of coagulation factors Va and VIIIa S homeolog (proc.S) antibody
  • protein C, inactivator of coagulation factors Va and VIIIa (proc) antibody
  • vitamin K-dependent protein C (CpipJ_CPIJ000393) antibody
  • vitamin K-dependent protein C (CpipJ_CPIJ002754) antibody
  • vitamin K-dependent protein C (CpipJ_CPIJ003717) antibody
  • vitamin K-dependent protein C (CpipJ_CPIJ003718) antibody
  • vitamin K-dependent protein C (CpipJ_CPIJ014440) antibody
  • vitamin K-dependent protein C (CpipJ_CPIJ018032) antibody
  • vitamin K-dependent protein C (CpipJ_CPIJ018737) antibody
  • protein C, inactivator of coagulation factors Va and VIIIa (Proc) antibody
  • protein C (Proc) antibody
  • APC antibody
  • MGC64425 antibody
  • PC antibody
  • PROC antibody
  • PROC1 antibody
  • si:ch1073-188c16.3 antibody
  • THPH3 antibody
  • THPH4 antibody
  • zgc:63987 antibody

Protein level used designations for PROC

protein C , procl , anticoagulant protein C , vitamin K-dependent protein C , protein C (inactivator of coagulation factors Va and VIIIa) , vitamin K-dependent protein C-like , autoprothrombin IIA , blood coagulation factor XIV , inactivator of coagulation factors Va, VIII , catalytic region , protein C (precursor of vitamin K-dependent serine protease)

GENE ID SPECIES
393327 Danio rerio
395085 Gallus gallus
459593 Pan troglodytes
100302329 Ovis aries
380116 Xenopus laevis
548476 Xenopus (Silurana) tropicalis
100231143 Taeniopygia guttata
100448857 Pongo abelii
6031231 Culex quinquefasciatus
6033948 Culex quinquefasciatus
6035053 Culex quinquefasciatus
6035054 Culex quinquefasciatus
6047546 Culex quinquefasciatus
6052150 Culex quinquefasciatus
6052641 Culex quinquefasciatus
25268 Rattus norvegicus
19123 Mus musculus
5624 Homo sapiens
281428 Bos taurus
101096161 Felis catus
476104 Canis lupus familiaris
100051306 Equus caballus
396954 Sus scrofa
100009223 Oryctolagus cuniculus
699077 Macaca mulatta
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