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PROC encodes a vitamin K-dependent plasma glycoprotein. Additionally we are shipping PROC Antibodies (34) and PROC Proteins (21) and many more products for this protein.
Showing 8 out of 22 products:
Mouse (Murine) PROC ELISA Kit for Sandwich ELISA - ABIN415711
Kawasaki, Okamoto, Kawasaki, Sata: Thrombomodulin improved liver injury, coagulopathy, and mortality in an experimental heatstroke model in mice. in Anesthesia and analgesia 2014
Data show that activated protein C signals via protease activated receptors PAR2 (show F2RL1 ELISA Kits)/PAR3 (show F2RL2 ELISA Kits) to expand Treg cells, mitigating the disease in mice.
insulin (show INS ELISA Kits) and aPC (show APC ELISA Kits) converge on a common spliced-X-box binding protein-1 (show XBP1 ELISA Kits) (sXBP1) signaling pathway to maintain endoplasmic reticulum (ER) homeostasis.
loss of the convertase furin (show FURIN ELISA Kits) or PC5 (show PCSK5 ELISA Kits)/6 in hepatocytes results in a approximately 30% decrease in APC (show APC ELISA Kits) levels, with no significant contribution from PACE4 (show PCSK6 ELISA Kits). We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin (show F2 ELISA Kits) activation.
APC (show APC ELISA Kits) modifies pulmonary fibrosis by limiting thrombin (show F2 ELISA Kits)-dependent macrophage recruitment.
Small interfering RNA-mediated silencing of protein C in apolipoprotein E (show APOE ELISA Kits)-deficient mice creates a condition that allows the occurrence of spontaneous atherothrombosis.
These findings reveal a novel biological function and mechanism of the protein C pathway in which protein S and the aPC (show APC ELISA Kits)-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC (show APC ELISA Kits) in the context of endotoxemia and infection
activated PC-EPCR-PAR1 signaling promotes hematopoietic stem cell retention in bone marrow.
impaired EPCR (show PROCR ELISA Kits)/protein C-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis
SOD prevents thrombomodulin (show THBD ELISA Kits) methionine oxidation, promotes protein C activation, and protects against arterial and venous thrombosis in mice.
sPLA2 (show PLA2G2A ELISA Kits)-V plays a thrombogenic role by impairing the ability of EPCR (show PROCR ELISA Kits) to promote protein C activation.
EPCR (show PROCR ELISA Kits) occupancy recruits G-protein coupled receptor kinase 5 (show GRK5 ELISA Kits), thereby inducing beta-arrestin-2 (show ARRB2 ELISA Kits) biased PAR1 (show MARK2 ELISA Kits) signaling by both APC (show APC ELISA Kits) and thrombin (show F2 ELISA Kits). In
A novel mutation of A309V in PROC was determined in a family of two patients with late onset protein C deficiency
Both probands had hereditary protein C deficiencies, for which their parents were all carriers.
Variants influencing circulating protein C levels in the CELSR2 (show CELSR2 ELISA Kits)-PSRC1 (show PSRC1 ELISA Kits)-SORT1 (show SORT1 ELISA Kits) region may indicate a novel genetic link between lipoprotein metabolism and hemostasis.
These findings suggest that the anti-inflammatory function of APC (show APC ELISA Kits) at therapeutic concentrations may include the inhibition of NETosis in an EPCR (show PROCR ELISA Kits)-, PAR3 (show F2RL2 ELISA Kits)-, and Mac-1 (show ITGAM ELISA Kits)-dependent manner, providing additional mechanistic insight into the diverse functions of neutrophils and APC (show APC ELISA Kits) in disease states including sepsis.
Collectively, these data depict a pivotal role for AMPK (show PRKAA1 ELISA Kits) signaling in inhibiting ER stress responses via the activation of APC (show APC ELISA Kits) during MGO-induced cardiomyocyte apoptosis. Thus, APC (show APC ELISA Kits) may be a potential novel therapeutic target for the management of diabetic cardiovascular complications such as diabetic cardiomyopathy.
An activation-resistant homozygous protein C R229W mutation was linked to perinatal intracranial bleeding and delayed onset of thrombosis.
Structural and functional studies of novel heterozygous mutations in the PROC gene confirmed that the mutations were pathogenetic in two Chinese families with types I and II protein C deficiency.
Study detected a statistically significant positive correlation between expanded disability status scale scores and thrombomodulin (show THBD ELISA Kits) levels (p<0.01) and a 10% positive correlation between expanded disability status scale scores and APC (show APC ELISA Kits) levels in multiple sclerosis patients
Activated protein c is a ghrelin (show GHRL ELISA Kits) endopeptidase.
Activated protein C(APC (show APC ELISA Kits)) combined with protein S(PS) had significant antithrombotic effect. APC (show APC ELISA Kits) combined with PS prolonged clotting time. Dependence on APC (show APC ELISA Kits)-cofactor activity of PS for expression of anticoagulant activity by APC (show APC ELISA Kits).
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
, anticoagulant protein C
, vitamin K-dependent protein C
, protein C (inactivator of coagulation factors Va and VIIIa)
, vitamin K-dependent protein C-like
, autoprothrombin IIA
, blood coagulation factor XIV
, inactivator of coagulation factors Va, VIII
, catalytic region
, protein C (precursor of vitamin K-dependent serine protease)