Protein C (Inactivator of Coagulation Factors Va and VIIIa) Proteins (PROC)

PROC encodes a vitamin K-dependent plasma glycoprotein. Additionally we are shipping PROC Antibodies (43) and PROC Kits (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PROC 25268 P31394
PROC 19123 P33587
PROC 5624 P04070
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Top PROC Proteins at antibodies-online.com

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Human Cells Human His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
Human Cells Mouse His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Horse His tag   1 mg Log in to see 60 to 71 Days
$2,352.17
Details
Yeast Goat His tag   1 mg Log in to see 60 to 71 Days
$2,352.17
Details
Yeast Cat His tag   1 mg Log in to see 60 to 71 Days
$2,352.17
Details
Yeast Rhesus Monkey His tag   1 mg Log in to see 60 to 71 Days
$2,365.00
Details
Yeast Dog His tag   1 mg Log in to see 60 to 71 Days
$3,151.50
Details

PROC Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Mouse (Murine) ,

Human , , , ,
,

More Proteins for Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) Interaction Partners

Mouse (Murine) Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) interaction partners

  1. Data show that activated protein C signals via protease activated receptors PAR2 (show F2RL1 Proteins)/PAR3 (show F2RL2 Proteins) to expand Treg cells, mitigating the disease in mice.

  2. insulin (show INS Proteins) and aPC (show APC Proteins) converge on a common spliced-X-box binding protein-1 (show XBP1 Proteins) (sXBP1) signaling pathway to maintain endoplasmic reticulum (ER) homeostasis.

  3. loss of the convertase furin (show FURIN Proteins) or PC5 (show PCSK5 Proteins)/6 in hepatocytes results in a approximately 30% decrease in APC (show APC Proteins) levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin (show F2 Proteins) activation.

  4. APC (show APC Proteins) modifies pulmonary fibrosis by limiting thrombin (show F2 Proteins)-dependent macrophage recruitment.

  5. Small interfering RNA-mediated silencing of protein C in apolipoprotein E (show APOE Proteins)-deficient mice creates a condition that allows the occurrence of spontaneous atherothrombosis.

  6. These findings reveal a novel biological function and mechanism of the protein C pathway in which protein S and the aPC (show APC Proteins)-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC (show APC Proteins) in the context of endotoxemia and infection

  7. activated PC-EPCR-PAR1 signaling promotes hematopoietic stem cell retention in bone marrow.

  8. impaired EPCR (show PROCR Proteins)/protein C-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis

  9. SOD prevents thrombomodulin (show THBD Proteins) methionine oxidation, promotes protein C activation, and protects against arterial and venous thrombosis in mice.

  10. sPLA2 (show PLA2G2A Proteins)-V plays a thrombogenic role by impairing the ability of EPCR (show PROCR Proteins) to promote protein C activation.

Human Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) interaction partners

  1. Using protein C-factor VII (show TH Proteins) chimera demonstrate that APC (show APC Proteins) light chain amino acid residues outside the EPCR (show PROCR Proteins)-binding site enable cytoprotective PAR1 (show MARK2 Proteins) signaling.

  2. We recently identified a venous thrombosis patient whose plasma level of protein C antigen is normal, but its anticoagulant activity is only 34 % of the normal level. Genetic analysis revealed that the proband and her younger brother carry a novel heterozygous mutation c.346G>A, p.Gly74Ser (G74S) in PROC.

  3. Developed functional protein S assays that measure both the activated protein C- and TFPI (show TFPI Proteins)-cofactor activities of protein S in plasma, which are hardly if at all affected by the FV Leiden mutation.

  4. Protein C seems inversely associated with mortality in patients with advanced prostate, lung and pancreatic cancer. Further research should validate protein C as a biomarker for mortality, and explore the effects of protein C on progression of cancer.

  5. Genetically higher protein C was associated with a lower risk of ischaemic heart disease.

  6. EPCR (show PROCR Proteins) occupancy recruits G-protein coupled receptor kinase 5 (show GRK5 Proteins), thereby inducing beta-arrestin-2 (show ARRB2 Proteins) biased PAR1 (show MARK2 Proteins) signaling by both APC (show APC Proteins) and thrombin (show F2 Proteins). In

  7. A novel mutation of A309V in PROC was determined in a family of two patients with late onset protein C deficiency

  8. loss of the convertase furin (show FURIN Proteins) or PC5 (show PCSK5 Proteins)/6 in hepatocytes results in a approximately 30% decrease in APC (show APC Proteins) levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin (show F2 Proteins) activation.

  9. Both probands had hereditary protein C deficiencies, for which their parents were all carriers.

  10. Variants influencing circulating protein C levels in the CELSR2 (show CELSR2 Proteins)-PSRC1 (show PSRC1 Proteins)-SORT1 (show SORT1 Proteins) region may indicate a novel genetic link between lipoprotein metabolism and hemostasis.

Cow (Bovine) Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) interaction partners

  1. Activated protein c is a ghrelin (show GHRL Proteins) endopeptidase.

  2. Activated protein C(APC (show APC Proteins)) combined with protein S(PS) had significant antithrombotic effect. APC (show APC Proteins) combined with PS prolonged clotting time. Dependence on APC (show APC Proteins)-cofactor activity of PS for expression of anticoagulant activity by APC (show APC Proteins).

PROC Protein Profile

Protein Summary

This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.

Gene names and symbols associated with PROC

  • protein C (inactivator of coagulation factors Va and VIIIa), a (proca)
  • protein C, inactivator of coagulation factors Va and VIIIa (PROC)
  • protein C (inactivator of coagulation factors Va and VIIIa) (PROC)
  • protein C, inactivator of coagulation factors Va and VIIIa S homeolog (proc.S)
  • protein C, inactivator of coagulation factors Va and VIIIa (proc)
  • vitamin K-dependent protein C (CpipJ_CPIJ000393)
  • vitamin K-dependent protein C (CpipJ_CPIJ002754)
  • vitamin K-dependent protein C (CpipJ_CPIJ003717)
  • vitamin K-dependent protein C (CpipJ_CPIJ003718)
  • vitamin K-dependent protein C (CpipJ_CPIJ014440)
  • vitamin K-dependent protein C (CpipJ_CPIJ018032)
  • vitamin K-dependent protein C (CpipJ_CPIJ018737)
  • protein C, inactivator of coagulation factors Va and VIIIa (Proc)
  • protein C (Proc)
  • APC protein
  • MGC64425 protein
  • PC protein
  • PROC protein
  • PROC1 protein
  • si:ch1073-188c16.3 protein
  • THPH3 protein
  • THPH4 protein
  • zgc:63987 protein

Protein level used designations for PROC

protein C , procl , anticoagulant protein C , vitamin K-dependent protein C , protein C (inactivator of coagulation factors Va and VIIIa) , vitamin K-dependent protein C-like , autoprothrombin IIA , blood coagulation factor XIV , inactivator of coagulation factors Va, VIII , catalytic region , protein C (precursor of vitamin K-dependent serine protease)

GENE ID SPECIES
393327 Danio rerio
395085 Gallus gallus
459593 Pan troglodytes
100302329 Ovis aries
380116 Xenopus laevis
548476 Xenopus (Silurana) tropicalis
100231143 Taeniopygia guttata
100448857 Pongo abelii
6031231 Culex quinquefasciatus
6033948 Culex quinquefasciatus
6035053 Culex quinquefasciatus
6035054 Culex quinquefasciatus
6047546 Culex quinquefasciatus
6052150 Culex quinquefasciatus
6052641 Culex quinquefasciatus
25268 Rattus norvegicus
19123 Mus musculus
5624 Homo sapiens
281428 Bos taurus
101096161 Felis catus
476104 Canis lupus familiaris
100051306 Equus caballus
396954 Sus scrofa
100009223 Oryctolagus cuniculus
699077 Macaca mulatta
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