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The protein encoded by PPP4R4 is a HEAT-like repeat-containing protein.
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PP4R4 forms a novel cytosolic complex with PP4c (show PPP4C Antibodies), independent from the complexes containing PP4R1 (show PPP4R1 Antibodies), PP4R2 (show PPP4R2 Antibodies).PP4R3, and alpha4, and the regulatory subunits of PP4c (show PPP4C Antibodies) have evolved different modes of interaction with the catalytic subunit
The protein encoded by this gene is a HEAT-like repeat-containing protein. The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins. Arrays of HEAT repeats form a rod-like helical structure and appear to function as protein-protein interaction surfaces. The repeat-containing region of this protein has some similarity to the constant regulatory domain of the protein phosphatase 2A PR65/A subunit. The function of this particular gene product has not been determined. Alternative splicing has been observed for this gene and two transcript variants encoding distinct isoforms have been identified.
HEAT-like repeat-containing protein
, serine/threonine-protein phosphatase 4 regulatory subunit 4