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PRC1 encodes a protein that is involved in cytokinesis.
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Results mechanistically explain how the two conserved, essential midzone proteins PRC1 and Xklp1 cooperate to constitute a minimal protein module capable of dynamically organizing the core structure of the central anaphase spindle.
We finally confirmed that PRC1 is a novel downstream target of piperlongumine in gastric cancer. Our findings supported the oncogenic role of PRC1 in gastric carcinogenesis. PRC1 might serve as a prognostic biomarker and potential therapeutic target for gastric carcinoma.
These findings suggest that the identified APLP2 (show APLP2 ELISA Kits), RRM2 (show RRM2 ELISA Kits), and PRC1 signature could be useful for distinguishing between benign (follicular adenoma) and malignant (follicular carcionma and follicular variant of papillary carcinoma) tumors of the thyroid follicular epithelium.
Near-atomic cryo-electron microscopy structure of PRC1 bound to the microtubule has been described.
study reveals that UbE2E1 is an in vivo E2 for the PRC1 ligase complex and thus plays an important role in the regulation of H2A Lys (show LYZ ELISA Kits)-119 monoubiquitination
PRC1 is a novel Wnt (show WNT2 ELISA Kits) target that functions in a positive feedback loop that reinforces Wnt (show WNT2 ELISA Kits) signalling to promote early Hepatocellular Carcinoma recurrence.
PRC1 rs10520699 and rs11852999 polymorphisms were associated with PRC1 transcript levels, but not with patients survival.
These findings suggest that the aberrant expression of PRC1 may predict biochemical recurrence in men with prostate cancer highlighting its potential as a prognostic marker of this malignancy.
PP2A (show PPP2R4 ELISA Kits)-B55 (show MINK1 ELISA Kits) dephosphorylates PRC1 at the metaphase to anaphase transition. This activity is regulated by the Greatwall (MASTL (show MASTL ELISA Kits)) kinase and its substrate ENSA (show ENSA ELISA Kits), explaining the timing of PRC1 activation in anaphase.
PRC1 complexes isolated from human cells contain multiple kinesins KIF4A, Kif20A (show KIF20A ELISA Kits), KIF23 and KIF14 (show KIF14 ELISA Kits).
PRC1 is a docking partner for the Polo kinase (show PLK1 ELISA Kits) Plk1 (show PLK1 ELISA Kits) in anaphase cells. During metaphase this is inhibited by Cdk1 (show CDK1 ELISA Kits)-cyclin B phosphorylation at T470 and T481.
Authors analyzed whether elevated levels of the polycomb repressor complex 1 (PRC1) components Bmi1 (show BMI1 ELISA Kits) and Ring1b (show RNF2 ELISA Kits) and their catalyzed histone modification H2AK119ub in ADMs and tumor cells, are responsible for the mediation of acinar gene silencing.
Here, the authors discover that the histone H2AK119 E3 ubiquitin ligase activity of Polycomb repressive complex 1 (PRC1) is defined by the composition of its catalytic subunits and is highly regulated by RYBP/YAF2-dependent stimulation.
Here, by combining live-cell single-molecule tracking (SMT) and genetic engineering, the authors reveal that H3K27me3 contributes significantly to the targeting of Cbx7-PRC1 complex to chromatin.
Pcgf6 (show PCGF6 ELISA Kits) is essential for recruitment of PRC1.6 to chromatin. Our results reveal a previously uncharacterized, H2AK119ub1-independent chromatin assembly associated with PRC1.6 complex
The data reveal how the interplay between PRC1, ncRNA and Mediator complexes controls pluripotency and cellular differentiation.
our findings show that PRC1 mediates gene repression by combining multiple and different effector mechanisms, of which H2A ubiquitination is a major contributor
This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants.
protein regulator of cytokinesis 1
, anaphase spindle elongation 1 homolog
, protein regulating cytokinesis 1