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The protein encoded by PTPN18 is a member of the protein tyrosine phosphatase (PTP) family. Additionally we are shipping PTPN18 Antibodies (32) and and many more products for this protein.
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PTPN18 regulates HER2 (show ERBB2 Proteins)-mediated cellular functions through defining both its phosphorylation and ubiquitination barcodes.
BDP1 has a role in negative regulation of HER2 (show ERBB2 Proteins) signaling
novel isoform of PTPN18 based on analysis of expressed sequence tags was discovered; deletion of 4 exons in the catalytic domain of the isoform may alter enzymatic activity; 2 of the novel isoform predictions were experimentally validated through RT-PCR
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene.
, tyrosine-protein phosphatase non-receptor type 18
, fetal liver phosphatase 1
, protein tyrosine phosphatase 20