anti-Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) Antibodies

PCMT1 encodes a member of the type II class of protein carboxyl methyltransferase enzymes. Additionally we are shipping Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Proteins (14) and Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Kits (12) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PCMT1 5110 P22061
PCMT1 18537  
PCMT1 25604 P22062
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Top anti-Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Antibodies at antibodies-online.com

Showing 10 out of 68 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated ELISA, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.73 KDa) . Dilution: 1:500~1000 100 μg Log in to see 8 to 11 Days
$461.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PCMT1 Antibody Titration:  2.5ug/ml  Positive Control:  HepG2 cell lysate PCMT1 is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Mouse Un-conjugated WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (50.82 KDa) . Dilution: 1:500~1000 PCMT1 monoclonal antibody (M01), clone 4G9 Western Blot analysis of PCMT1 expression in PC-12 ( (# ABIN393808 ) Dilution: 1:500~1000 100 μg Log in to see 8 to 11 Days
$461.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: PCMT1 Antibody [NBP1-85806] - Staining of human cell line A-431 shows positivity in cytoplasm. Western Blot: PCMT1 Antibody [NBP1-85806] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10.Lane 2: Human Cerebral Cortex tissue 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Bat Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded U87 xenograft, using PCMT1, antibody at 1:500 dilution. WB Image Sample (30 ug of whole cell lysate) A: 293T 12% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Mouse Un-conjugated ELISA, WB PCMT1 monoclonal antibody (M02), clone 1D6 Western Blot analysis of PCMT1 expression in HeLa . Detection limit for recombinant GST tagged PCMT1 is approximately 0.1ng/ml as a capture antibody. 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), IHC, WB Immunocytochemistry/Immunofluorescence: PCMT1 Antibody [NBP1-33019] - Analysis of methanol-fixed A431, using antibody at 1:200 dilution. Western Blot: PCMT1 Antibody [NBP1-33019] - A: 293T. 0.1 mL Log in to see 8 to 11 Days
$514.63
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg Log in to see 13 to 16 Days
$386.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-PCMT1 Polyclonal Antibody, Unconjugated (ABIN715796) at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$306.90
Details

Top referenced anti-Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Antibodies

  1. Human Polyclonal PCMT1 Primary Antibody for ICC, IF - ABIN4344090 : Forsström, Axnäs, Stengele, Bühler, Albert, Richmond, Hu, Nilsson, Hudson, Rockberg, Uhlen: Proteome-wide epitope mapping of antibodies using ultra-dense peptide arrays. in Molecular & cellular proteomics : MCP 2014 (PubMed)

More Antibodies against Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Interaction Partners

Human Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) interaction partners

  1. decrease of PCMT1 significantly increased the proportion of D-Asp (show ASIP Antibodies) residues in PHB1 (show PHB Antibodies) and had significant and fatal impacts on morphology and functions of the mitochondria, such as ATP production and the mitochondrial fusion-fission system

  2. PIMT heterozygosity for R36C, G175R, R17H, or R17S would be detrimental to successful aging, whereas homozygosity (should it ever occur) would produce devastating neuropathology

  3. Strong PIMT expression was a predictive marker of poor prognosis for surgically resected lung adenocarcinoma.

  4. The data of this study indicated that DA-associated PIMT downregulation is an important event contributing to neuronal cell death

  5. ERK2 (show MAPK1 Antibodies)-mediated phosphorylation of transcriptional coactivator binding protein PIMT/NCoA6IP (show TGS1 Antibodies) at Ser298 augments hepatic gluconeogenesis.

  6. Overexpression of PCMT1 attentuates Mst1 (show MST1 Antibodies) kinase activation and its apoptotic effects in response to hypoxia-induced injury in cardiomyocytes.

  7. Data indicate that human PROTEIN ISOASPARTYL METHYLTRANSFERASE (PIMT) can initiate isoAsp conversion to Asp (show ASIP Antibodies), and is able to restore Arabidopsis PRH75 (show DDX46 Antibodies)'s complex biochemical activity provided isoAsp formation has not led to conformational alterations.

  8. Data show six differentially expressed proteins were identified as HSP70 (show HSP70 Antibodies), PPIA (show PPIA Antibodies) and alpha-Enolase (up-regulated) S100-A9, PIMT and beta-5 tubulin (show TUBB Antibodies) (down-regulated), most of which had been shown to play a potential role in the pathogenesis of atherosclerosis.

  9. The results implied that maternal polymorphisms in PCMT1 might be a potential genetic risk factor for isolated anencephaly in the Chinese population of Lvliang.

  10. Study provides new insight into the molecular mechanisms by which PIMT suppresses the p53 (show TP53 Antibodies) activity through carboxyl methylation, and suggests a therapeutic target for cancers.

Mouse (Murine) Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) interaction partners

  1. Loss of normal CKB (show CHKB Antibodies) structure and function contributes to the mechanisms by which isoaspartate accumulation leads to central nervous system dysfunction in the PIMT-Knockout mouse.

  2. PIMT levels may significantly influence the course of age-related central nervous system dysfunction.

  3. ERK2 (show MAPK1 Antibodies)-mediated phosphorylation of transcriptional coactivator binding protein PIMT/NCoA6IP (show TGS1 Antibodies) at Ser298 augments hepatic gluconeogenesis.

  4. PIMT knockout mice have perturbations in glutamate (show GRIN1 Antibodies) metabolism in the brain and die prematurely of epileptic seizures.

  5. synuclein is not a major target of PIMT in vivo

  6. Altered levels of S-adenosylmethionine and S-adenosylhomocysteine in the brains of PCMT1 knockout mice

  7. Recombinant adeno (show ADORA2A Antibodies)-PIMT improved the symptoms of PIMT-deficient mice in vivo, but only partially repaired IsoAsp in damaged proteins.

  8. An accumulation of isoaspartyl residues in cells of mice lacking the isoaspartyl repair enzyme PCMT alters the effector function of T lymphocytes leading to autoantibody production.

  9. Pcmt1-/- mice have altered regulation of the insulin (show INS Antibodies) pathway, possibly as a compensatory response to altered glucose uptake or metabolism or as an adaptive response to a general accumulation of isoaspartyl protein damage in the brain and other tissues.

  10. Protein L-isoaspartyl methyltransferase (PIMT) catalyzes in vivo racemization of Asp (show C3 Antibodies)-25 in mammalian histone H2B, suggesting that PIMT functions in the repair, rather than the metabolic turnover, of isoaspartyl proteins in vivo.

Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) Antigen Profile

Protein Summary

This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with PCMT1

  • protein-L-isoaspartate (D-aspartate) O-methyltransferase (PCMT1) antibody
  • protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 (Pcmt1) antibody
  • protein-L-isoaspartate (D-aspartate) O-methyltransferase L homeolog (pcmt1.L) antibody
  • protein-L-isoaspartate(D-aspartate)O-methyltransferase (pcmt1) antibody
  • protein-L-isoaspartate (D-aspartate) O-methyltransferase (Pcmt1) antibody
  • protein-L-isoaspartate (D-aspartate) O-methyltransferase (pcmt) antibody
  • C79501 antibody
  • etID309741.20 antibody
  • fj13d06 antibody
  • PCM antibody
  • PCMT antibody
  • pimt antibody
  • wu:fj13d06 antibody

Protein level used designations for PCMT1

L-isoaspartyl protein carboxyl methyltransferase , protein L-isoaspartyl/D-aspartyl methyltransferase , protein-L-isoaspartate(D-aspartate) O-methyltransferase , protein-beta-aspartate methyltransferase , protein carboxyl methyltransferase , PIMT , protein carboxyl-o-methyltransferase , protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 , Protein L-isoaspartyl/D-aspartyl methyltransferase , Protein-beta-aspartate methyltransferase , l-isoaspartyl protein carboxyl methyltransferase

GENE ID SPECIES
5110 Homo sapiens
18537 Mus musculus
25604 Rattus norvegicus
428607 Gallus gallus
476242 Canis lupus familiaris
100502562 Sus scrofa
613854 Bos taurus
495685 Xenopus laevis
100172708 Pongo abelii
380580 Xenopus laevis
100731541 Cavia porcellus
30751 Danio rerio
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