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Plays a role in boundary lubrication within articulating joints. Additionally we are shipping Proteoglycan 4 (Megakaryocyte Stimulating Factor, Articular Superficial Zone Protein) Antibodies (20) and Proteoglycan 4 (Megakaryocyte Stimulating Factor, Articular Superficial Zone Protein) Kits (7) and many more products for this protein.
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Human PRG4 Protein expressed in Wheat germ - ABIN5648443
Liu, Tefft, Roberts, Zhang, Ren, Li, Huang, Zhang, Phillips, Wu: Cardioprotective proteins upregulated in the liver in response to experimental myocardial ischemia. in American journal of physiology. Heart and circulatory physiology 2012
Intra-articular injection of human PRG4 in vivo in Prg4-/- mice prevented caspase-3 (show CASP3 Proteins) activation in superficial zone chondrocytes and was associated with a modest decrease in whole joint friction.
Data indicate that Prg4 is needed for the temporomandibular joint integrity and long-term postnatal function. In its absence, progenitor cells near presumptive articular layer and disc undergo ectopic chondrogenesis and generate ectopic cartilage, possibly driven by aberrant activation of Hh signaling.
Prg4 is needed for TMJ disc integrity and function and its absence leads to ectopic chondrogenesis and cartilage formation in conjunction with abnormal BMP signaling.
Discs from Prg4 null mice had a significantly smaller mean transverse disc area, with a significantly larger proportion of this area occupied by the nucleus pulposus.
PRG4 is a novel putative ligand for CD44 (show CD44 Proteins) and may control synoviocyte overgrowth in inflammatory arthropathies via a CD44 (show CD44 Proteins)-mediated mechanism.
Prg4-expressing cells at the embryonic joint surface serve as a progenitor population for deeper layers of mature articular cartilage. Prg4 is expressed by superficial chondrocytes in young mice but in deeper regions of articular cartilage in older mice.
findings confirm the importance of lubricin in intrasynovial tendon lubrication.
mechanical motion may induce Prg4 expression in the superficial zone of articular cartilage
changes in synovial fluid proteins and PRG4 concentrations upon joint loading are mediated by cells within the joint, and that these changes may be used as quantitative indicators for the intensity and duration of acute joint loading
Lubricin is transcribed, translated, and expressed by ocular surface epithelia. Lubricin presence significantly reduces friction between the cornea and conjunctiva and its deficiency may play a role in promoting corneal damage.
Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.
proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome)
, megakaryocyte-stimulating factor
, proteoglycan 3
, proteoglycan 4
, superficial zone proteoglycan