Proteoglycan 4 Proteins (PRG4)

The protein encoded by PRG4 is a large proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. Additionally we are shipping Proteoglycan 4 Antibodies (61) and Proteoglycan 4 Kits (35) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PRG4 10216 Q92954
PRG4 289104  
PRG4 96875 Q9JM99
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Proteoglycan 4 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$752.00
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$230.67
Details
Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$318.85
Details

PRG4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)
Mouse (Murine) ,

Top referenced Proteoglycan 4 Proteins

  1. Human Proteoglycan 4 Protein expressed in Wheat germ - ABIN5648443 : Liu, Tefft, Roberts, Zhang, Ren, Li, Huang, Zhang, Phillips, Wu: Cardioprotective proteins upregulated in the liver in response to experimental myocardial ischemia. in American journal of physiology. Heart and circulatory physiology 2012 (PubMed)

More Proteins for Proteoglycan 4 (PRG4) Interaction Partners

Human Proteoglycan 4 (PRG4) interaction partners

  1. Inflammatory Biomarker Profiling in Total Joint Arthroplasty and Its Relevance to Circulating Levels of Lubricin, a Novel Proteoglycan.

  2. Intra-articular injection of human PRG4 in vivo in Prg4-/- mice prevented caspase-3 activation in superficial zone chondrocytes and was associated with a modest decrease in whole joint friction.

  3. PRG4 plays an important anti-inflammatory role in regulating osteoarthritis synoviocyte proliferation.

  4. IL6 and PRG4 represent potential novel tissue biomarkers of disease severity and prognosis in conjunctival fibrosis after glaucoma surgery.

  5. adult talar cartilage increases both PRG4 release and biosynthetic activity as immediate cellular response to injury

  6. Double knockdown of PRG4 and IL-24 did not inhibit myxoid liposarcoma (MLS)- cell growth, and single knockdown of PRG4 remarkably increased IL-24 expression. These results suggest that the growth inhibitory effect of PRG4 knockdown is caused by induction of IL-24 expression, and PRG4 may contribute to maintain MLS cell growth through repression of IL-24 expression.

  7. lubricin expression may typify adaptive and neoplastic changes along a pathway toward fibroblast-like synoviocytes

  8. PRG4 binds to TLR2 and TLR4 and this binding mediates a novel anti-inflammatory role for PRG4.

  9. Cartilage derived from MSCs expressed lubricin protein both in vitro and in vivo

  10. no synovial fluid level differences detected between healthy knees and injured knees

  11. The finding that rhPRG4 can increase the viscosity of low concentration HA solutions suggests that supplementation with rhPRG4 may help mitigate the loss in synovial fluid viscosity experienced with decreased HA concentration in osteoarthritis.

  12. PRG4 is a novel putative ligand for CD44 and may control synoviocyte overgrowth in inflammatory arthropathies via a CD44-mediated mechanism.

  13. The O-glycomap of lubricin, a novel mucin responsible for joint lubrication, has been identified by site-specific glycopeptide analysis.

  14. Lubricin (Prg4) plays a role in preventing damage to the superficial zone and preservation of chondrocytes. [Review]

  15. 5 novel PRG4 mutations and the first case of CACP syndrome resulting from uniparental disomy of chromosome 1.

  16. We speculate that an important role of lubricin in mediating interactions at the cartilage surface is to attach to the cartilage surface and provide a protective coating that maintains the contacting surfaces in a sterically repulsive state.

  17. Lubricin is transcribed, translated, and expressed by ocular surface epithelia. Lubricin presence significantly reduces friction between the cornea and conjunctiva.

  18. The objective was to evaluate the presence and distribution of the lubricating and anti-adhesion glycoprotein lubricin and cells containing the contractile isoform smooth muscle alpha-actin (SMA) in pseudomembranes around loose hip prostheses.

  19. the identification of a novel null mutation in PRG4 confirming the genetic homogeneity of Camptodactyly-arthropathy-coxa vara-pericarditis syndrome .

  20. Production and accumulation of the superficial zone protein (SZP), also known as lubricin, by the surface zone is a characteristic feature of articular cartilage.

Cow (Bovine) Proteoglycan 4 (PRG4) interaction partners

  1. TGF-beta1 stimulated lubricin secretion by superficial zone chondrocytes at all densities with twice-a-week TGF-beta treatment. It is noteworthy that the daily treatment of TGF-beta1 increased lubricin much higher compared with twice-a-week treatment.

  2. the intermolecular disulfide-bonded multimeric structure of PRG4 is important for its ability to adsorb to a cartilage surface and function as a boundary lubricant.

  3. The present investigation provides novel insights into the role of the Wnt signalling pathways in SZP accumulation in synoviocytes and their roles in the homeostasis of normal joints.

  4. The important role of PRG4 in reducing friction in the tissues and compartments of the knee/stifle joint.

  5. The role of cell surface glycosaminoglycans (GAGs) during TGF-beta1 stimulation of SZP/lubricin/PRG4 in superficial zone articular chondrocytes, was investigated.

  6. Lubricin expression in explant cartilage was also suppressed under hypoxia

  7. The finding that rhPRG4 can increase the viscosity of low concentration HA solutions suggests that supplementation with rhPRG4 may help mitigate the loss in synovial fluid viscosity experienced with decreased HA concentration in osteoarthritis.

  8. SZP production is dependent on the functional cytoskeleton, and Rho GTPases contribute to SZP accumulation by modulating the actions of TGFbeta.

  9. the combined treatment with TGF-beta1 and BMP-7 or treatment first with TGF-beta1 followed by BMP-7 was more effective than other treatment groups in both chondrogenic differentiation and SZP secretion.

  10. A variety of monomeric PRG4 proteins and a disulfide-bonded dimer/multimer are secreted by chondrocytes in bovine cartilage explants.

  11. proteoglycan 4 expression and chondrocyte phenotype is invluenced by matrix molecules and alginate-embedded zonal chondrocytes and mesenchymal stem cells

  12. These findings suggest a generalized approach which may be used for molecular resurfacing of tissue surfaces with PRG4 and other lubricating biomolecules.

  13. Mesenchymal progenitor cells derived from synovium and infrapatellar fat pad as a source for superficial zone cartilage tissue engineering: analysis of superficial zone protein/lubricin expression.

  14. Present at surface of fibrocartilaginous regions of tendon, increasing with age. Cytoprotective role preventing cellular adhesion to tendon surface and providing lubrication during normal tendon function.

  15. In both explant and monolayer cultures, BMP-7 increased SZP accumulation in a dose- and time-dependent fashion (p < 0.05).

  16. Collectively, the results of studies on cytokine and growth factor regulation of lubricin biosynthesis and biodistribution may help provide new insights and therapeutic perspectives for promoting joint function.

  17. PRG$ mRNA expression level was markedly increaswed by ball oscillation.

  18. Accumulation of this protein by TGFbeta/bone morphogenetic proteins is regulated differently in articular chondrocytes and synoviocytes.

  19. An unexpected pattern of SZP localization in knee cartilage was initially identified, with anterior regions exhibiting high levels of SZP expression

  20. Chondrogenically differentiated infrapatellar fat pad progenitor cells were stimulated by TGF-beta1 and BMP-7 to synthesize and secrete SZP.

Horse (Equine) Proteoglycan 4 (PRG4) interaction partners

  1. This is the first demonstration of a change in the glycosylation profile of lubricin in synovial fluid from diseased equine joints compared with that from normal joints; it demonstrate an identical proteolytic cleavage site of lubricin both in vitro and in vivo.

  2. galectin-3 reinforces the lubricin boundary layer; which, in turn, enhances cartilage lubrication and may delay the onset and progression of arthritis.

Mouse (Murine) Proteoglycan 4 (PRG4) interaction partners

  1. Intra-articular injection of human PRG4 in vivo in Prg4-/- mice prevented caspase-3 activation in superficial zone chondrocytes and was associated with a modest decrease in whole joint friction.

  2. Data indicate that Prg4 is needed for the temporomandibular joint integrity and long-term postnatal function. In its absence, progenitor cells near presumptive articular layer and disc undergo ectopic chondrogenesis and generate ectopic cartilage, possibly driven by aberrant activation of Hh signaling.

  3. Prg4 is needed for TMJ disc integrity and function and its absence leads to ectopic chondrogenesis and cartilage formation in conjunction with abnormal BMP signaling.

  4. Discs from Prg4 null mice had a significantly smaller mean transverse disc area, with a significantly larger proportion of this area occupied by the nucleus pulposus.

  5. PRG4 is a novel putative ligand for CD44 and may control synoviocyte overgrowth in inflammatory arthropathies via a CD44-mediated mechanism.

  6. Prg4-expressing cells at the embryonic joint surface serve as a progenitor population for deeper layers of mature articular cartilage. Prg4 is expressed by superficial chondrocytes in young mice but in deeper regions of articular cartilage in older mice.

  7. findings confirm the importance of lubricin in intrasynovial tendon lubrication.

  8. mechanical motion may induce Prg4 expression in the superficial zone of articular cartilage

  9. changes in synovial fluid proteins and PRG4 concentrations upon joint loading are mediated by cells within the joint, and that these changes may be used as quantitative indicators for the intensity and duration of acute joint loading

  10. Lubricin is transcribed, translated, and expressed by ocular surface epithelia. Lubricin presence significantly reduces friction between the cornea and conjunctiva and its deficiency may play a role in promoting corneal damage.

  11. lubricin has roles in boundary lubrication, and cell survival

  12. Blunted PTH anabolic responses in adult Prg4 mutant mice are associated with altered biomechanical impact secondary to joint failure.

  13. lubricin expression has an effect on the viscoelastic properties of tendon fascicles

  14. the absence of lubricin is associated with increased interfascicular friction and that lubricin may play an important role in interfascicular lubrication

  15. These findings suggest that PRG4 plays a significant role in preserving normal joint structure and function.

  16. Expression is characteristic ofmyxoid liposarcoma and is also a frequent finding also in various other sarcomas.

  17. Data describe the expression of Prg4 mRNA during mouse joint development and in lubricin-mutant mice

  18. lubricin degradation occurring in inflammatory joint diseases predisposes the cartilage to damage

Pig (Porcine) Proteoglycan 4 (PRG4) interaction partners

  1. Lubricin is transcribed, translated, and expressed by ocular surface epithelia. Lubricin presence significantly reduces friction between the cornea and conjunctiva.

Rabbit Proteoglycan 4 (PRG4) interaction partners

  1. Lubricin/PRG4 gene expression was increased in medial collateral ligaments after 14 weeks of menopause in adult rabbits.

  2. The mRNA expression levels for lubricin/proteoglycan 4 (PRG4) and tissue inhibitor of metalloproteinase-3 increase with aging.

Proteoglycan 4 (PRG4) Protein Profile

Protein Summary

The protein encoded by this gene is a large proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Proteoglycan 4 Proteins (PRG4)

  • proteoglycan 4 (PRG4)
  • proteoglycan 4 (Prg4)
  • proteoglycan 4b (prg4b)
  • proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) (Prg4)
  • bG174L6.2 protein
  • CACP protein
  • DOL54 protein
  • HAPO protein
  • JCAP protein
  • lubricin protein
  • MSF protein
  • PRG4 protein
  • si:dkey-97o5.3 protein
  • SZP protein
  • zgc:122988 protein

Protein level used designations for Proteoglycan 4 Proteins (PRG4)

articular superficial zone protein , bG174L6.2 (MSF: megakaryocyte stimulating factor ) , lubricin , megakaryocyte stimulating factor , megakaryocyte-stimulating factor , superficial zone proteoglycan , MLL septin-like fusion , proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome) , proteoglycan 4 , p53-responsive gene 4 , proteoglycan 3

GENE ID SPECIES
10216 Homo sapiens
280867 Bos taurus
289104 Rattus norvegicus
553377 Danio rerio
768493 Gallus gallus
100034016 Equus caballus
100294585 Ovis aries
96875 Mus musculus
664716 Canis lupus familiaris
100518683 Sus scrofa
100347000 Oryctolagus cuniculus
100716004 Cavia porcellus
Selected quality suppliers for Proteoglycan 4 Proteins (PRG4)
Did you look for something else?