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The protein encoded by PRG4 is a large proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells.
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Intra-articular injection of human PRG4 in vivo in Prg4-/- mice prevented caspase-3 (show CASP3 Proteins) activation in superficial zone chondrocytes and was associated with a modest decrease in whole joint friction.
PRG4 plays an important anti-inflammatory role in regulating osteoarthritis synoviocyte proliferation.
IL6 (show IL6 Proteins) and PRG4 represent potential novel tissue biomarkers of disease severity and prognosis in conjunctival fibrosis after glaucoma surgery.
adult talar cartilage increases both PRG4 release and biosynthetic activity as immediate cellular response to injury
Double knockdown of PRG4 and IL-24 (show IL24 Proteins) did not inhibit myxoid liposarcoma (MLS)- cell growth, and single knockdown of PRG4 remarkably increased IL-24 (show IL24 Proteins) expression. These results suggest that the growth inhibitory effect of PRG4 knockdown is caused by induction of IL-24 (show IL24 Proteins) expression, and PRG4 may contribute to maintain MLS cell growth through repression of IL-24 (show IL24 Proteins) expression.
lubricin expression may typify adaptive and neoplastic changes along a pathway toward fibroblast-like synoviocytes
PRG4 binds to TLR2 and TLR4 (show TLR4 Proteins) and this binding mediates a novel anti-inflammatory role for PRG4.
Cartilage derived from MSCs expressed lubricin protein both in vitro and in vivo
PRG4 is a novel putative ligand for CD44 (show CD44 Proteins) and may control synoviocyte overgrowth in inflammatory arthropathies via a CD44 (show CD44 Proteins)-mediated mechanism.
The O-glycomap of lubricin, a novel mucin (show SLC13A2 Proteins) responsible for joint lubrication, has been identified by site-specific glycopeptide analysis.
TGF-beta1 (show TGFB1 Proteins) stimulated lubricin secretion by superficial zone chondrocytes at all densities with twice-a-week TGF-beta (show TGFB1 Proteins) treatment. It is noteworthy that the daily treatment of TGF-beta1 (show TGFB1 Proteins) increased lubricin much higher compared with twice-a-week treatment.
the intermolecular disulfide-bonded multimeric structure of PRG4 is important for its ability to adsorb to a cartilage surface and function as a boundary lubricant.
The present investigation provides novel insights into the role of the Wnt (show WNT2 Proteins) signalling pathways in SZP accumulation in synoviocytes and their roles in the homeostasis of normal joints.
The important role of PRG4 in reducing friction in the tissues and compartments of the knee/stifle joint.
The role of cell surface glycosaminoglycans (GAGs) during TGF-beta1 (show TGFB1 Proteins) stimulation of SZP/lubricin/PRG4 in superficial zone articular chondrocytes, was investigated.
Lubricin expression in explant cartilage was also suppressed under hypoxia
SZP production is dependent on the functional cytoskeleton, and Rho GTPases contribute to SZP accumulation by modulating the actions of TGFbeta (show TGFB1 Proteins).
the combined treatment with TGF-beta1 (show TGFB1 Proteins) and BMP-7 (show BMP7 Proteins) or treatment first with TGF-beta1 (show TGFB1 Proteins) followed by BMP-7 (show BMP7 Proteins) was more effective than other treatment groups in both chondrogenic differentiation and SZP secretion.
A variety of monomeric PRG4 proteins and a disulfide-bonded dimer/multimer are secreted by chondrocytes in bovine cartilage explants.
proteoglycan 4 expression and chondrocyte phenotype is invluenced by matrix molecules and alginate-embedded zonal chondrocytes and mesenchymal stem cells
Data indicate that Prg4 is needed for the temporomandibular joint integrity and long-term postnatal function. In its absence, progenitor cells near presumptive articular layer and disc undergo ectopic chondrogenesis and generate ectopic cartilage, possibly driven by aberrant activation of Hh signaling.
Prg4 is needed for TMJ disc integrity and function and its absence leads to ectopic chondrogenesis and cartilage formation in conjunction with abnormal BMP signaling.
Discs from Prg4 null mice had a significantly smaller mean transverse disc area, with a significantly larger proportion of this area occupied by the nucleus pulposus.
Prg4-expressing cells at the embryonic joint surface serve as a progenitor population for deeper layers of mature articular cartilage. Prg4 is expressed by superficial chondrocytes in young mice but in deeper regions of articular cartilage in older mice.
findings confirm the importance of lubricin in intrasynovial tendon lubrication.
mechanical motion may induce Prg4 expression in the superficial zone of articular cartilage
changes in synovial fluid proteins and PRG4 concentrations upon joint loading are mediated by cells within the joint, and that these changes may be used as quantitative indicators for the intensity and duration of acute joint loading
Lubricin is transcribed, translated, and expressed by ocular surface epithelia. Lubricin presence significantly reduces friction between the cornea and conjunctiva and its deficiency may play a role in promoting corneal damage.
Lubricin is transcribed, translated, and expressed by ocular surface epithelia. Lubricin presence significantly reduces friction between the cornea and conjunctiva.
Lubricin/PRG4 gene expression was increased in medial collateral ligaments after 14 weeks of menopause in adult rabbits.
The mRNA expression levels for lubricin/proteoglycan 4 (PRG4) and tissue inhibitor of metalloproteinase-3 (show TIMP3 Proteins) increase with aging.
The protein encoded by this gene is a large proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.
articular superficial zone protein
, bG174L6.2 (MSF: megakaryocyte stimulating factor )
, megakaryocyte stimulating factor
, megakaryocyte-stimulating factor
, superficial zone proteoglycan
, MLL septin-like fusion
, proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome)
, proteoglycan 4
, p53-responsive gene 4
, proteoglycan 3