anti-R-Spondin 1 (RSPO1) Antibodies

RSPO1 is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. Additionally we are shipping R-Spondin 1 Kits (35) and R-Spondin 1 Proteins (25) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RSPO1 313589  
RSPO1 284654 Q2MKA7
RSPO1 192199 Q9Z132
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Top anti-R-Spondin 1 Antibodies at antibodies-online.com

Showing 10 out of 72 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, IHC (p), WB Western Blot: R-Spondin 1 Antibody [NBP1-77354] - Rat spleen tissue lysate with RSPO1 antibody at (A) 1 and (B) 2 ug/mL. Immunohistochemistry: R-Spondin 1 Antibody [NBP1-77354] - Analysis of RSPO1 in human heart tissue with RSPO1 antibody at 2.5 ug/ml. 0.1 mg Log in to see 8 to 11 Days
$488.73
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated ELISA, WB Figure 1: Western blot analysis using R-spondin1 mouse mAb against recombinant R-spondin1 protein (1) and R-spondin1(aa21-263)-hIgGFc transfected HEK293 cell lysate(2). Dilution: 1/500 - 1/2000 100 μL Log in to see 10 to 11 Days
$491.79
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Mouse Spinal Cord Tissue. 100 μg Log in to see 13 to 16 Days
$396.00
Details
Rat Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Rat Uterus Tissue. 100 μg Log in to see 15 to 18 Days
$418.00
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of extract of various cells, using RSPO1 antibody. Immunohistochemistry of paraffin-embedded rat lung using RSPO1 antibody at dilution of 1:100 (40x lens). 100 μL Log in to see 16 Days
$366.77
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 14 to 16 Days
$218.90
Details
Human Rabbit Un-conjugated ICC, IHC, WB DAB staining on IHC-P; Samples: Human Breast cancer Tissue 100 μg Log in to see 13 to 16 Days
$386.00
Details
Rat Rabbit Un-conjugated ICC, IHC, WB DAB staining on IHC-P; Samples: Rat Heart Tissue 100 μg Log in to see 13 to 16 Days
$418.00
Details

Top referenced anti-R-Spondin 1 Antibodies

  1. Human Monoclonal RSPO1 Primary Antibody for ELISA, WB - ABIN969375 : Parma, Radi, Vidal, Chaboissier, Dellambra, Valentini, Guerra, Schedl, Camerino: R-spondin1 is essential in sex determination, skin differentiation and malignancy. in Nature genetics 2006 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal RSPO1 Primary Antibody for ELISA, ICC - ABIN4348849 : Takahashi, Sato, Kurashima, Yamamoto, Kurokawa, Yuki, Takemura, Uematsu, Lai, Otsu, Matsuno, Osawa, Mizushima, Nishimura, Hayashi, Yamaguchi, Kiyono: A Refined Culture System for Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids. in Stem cell reports 1970 (PubMed)

More Antibodies against R-Spondin 1 Interaction Partners

Human R-Spondin 1 (RSPO1) interaction partners

  1. first report of a RSPO1 missense mutation in association with human disease (familial 46,XX disorder of sexual development) .

  2. Rspo1 increases the number of Lgr5(+) liver stem cells in human liver fibrosis tissues, and once they are isolated, these cells are able to form organoids, and treatment with HGF/Rspo1 promotes their expansion

  3. RSPOs facilitate HSC activation and promote liver fibrogenesis by enhancing the Wnt pathway

  4. Role of RSPO1 in gastric cancer

  5. Results showed that Rspo1 expression is downregulated in adult follicles but its activation is sufficient in promoting ovarian tumors supporting its direct involvement in the initiation of ovarian cancers.

  6. We highlight the cooperation of WNT4, RSPO1 and FOXL2 within a regulatory network and the need for further research to better understand their role in defining and maintaining ovarian identity.

  7. Rspo1 glycosylation at Asn137 is essential for secretion and stability but not for heparin binding.

  8. DPY19L3-mediated C-mannosylation of Rspo1 at tryptophan(156) is required for Rspo1 secretion.

  9. Genetic variants in ZC3H11B, RSPO1, and GJD2 are associated with susceptibility to the development of high myopia in a Han Chinese population.

  10. R-Spondin1 has an effect on radiosensitivity of glioma cells

  11. ZNRF3 and LGR4-binding sites in RSPO1 are required for Wnt signaling.

  12. Changes in the expression levels of IRS1, IRS2, RIPK2, RSPO1, and DNA JC15 genes might contribute to the development of insulin resistance and glucose intolerance in the obese boys.

  13. the LGR4-Rspo1 complex crystal structure shows divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors

  14. ZNRF3 binds RSPO1 and LGR5-RSPO1 with micromolar affinity via RSPO1 furin-like 1 (Fu1) domain.

  15. overexpressed in fibrotic liver tissue

  16. Loss of RSPO1 expression is associated with invasive ductal carcinoma of the breast.

  17. RSPO-LGR4 not only induces the clearance of RNF43/ZNRF3 to increase Wnt receptor levels but also recruits IQGAP1 into the Wnt signaling complex.

  18. Crystal structures of the Lgr4 ectodomain alone and bound to Rspo1.

  19. In conclusion, present study highlights the role of Rspo 1 in bone remodeling where it activates Wnt signaling to induce differentiation, as shown in human as well murine in vitro osteoblast cell models.

  20. Recent developments have demonstrated that ovarian development is an active process (rather than a default process); ovarian development/function requires expression of RSPO1, WNT4, and FOXL2. [REVIEW]

Mouse (Murine) R-Spondin 1 (RSPO1) interaction partners

  1. reciprocal control of antagonistic Wnt signaling pathways by Rspo1 in muscle stem cell progeny is a key step ensuring normal tissue architecture restoration following acute damage.

  2. In Rspo1 knock-out mice during pregnancy, a stronger expression of mesenchymal markers was observed, without modifications to the structure of mammary epithelial tissue. Mammary epithelial cell immunohistochemical analysis revealed a persistence of virgin markers, which signify a delay in cell differentiation.

  3. RSPO-LGR4/5-ZNRF3/RNF43 module controls metabolic liver zonation and is a hepatic growth/size rheostat during development, homeostasis and regeneration.

  4. Rspo1 and its receptor of leucine-rich repeat containing G-protein-coupled receptor 4 (Lgr4) should be a novel molecular signal in the transmission of mechanical stimuli to biological signal in the bone, and this signal should be in the upstream of Wnt/beta-catenin signaling for bone formation.

  5. We also show that R-spondin1 is depleted in RANK-null progenitors, and that its exogenous administration rescues key aspects of RANK deficiency by reinstating a WNT response and mammary cell expansion

  6. R-spondin 1/dickkopf-1/beta-catenin machinery is involved in testicular embryonic angiogenesis

  7. The ascl2 is regulated in a direct autoactivatory loop, leading to a distinct on/off expression pattern, and Wnt/R-spondin can activate this regulatory loop.

  8. RSPO1, WNT4, and beta-catenin have roles in the signaling pathway during ovarian differentiation in mice.

  9. Rspo1 is required for ovarian differentiation by activation of the WNT/CTNNB1 signalling pathway

  10. Rspo1 is involved in maintenance of the immature state of the progenitors of the granulosa cells of the ovary

  11. this study identifies Rspo1 and Wnt4 as two new regulators of cell proliferation in the early gonad regardless of its sex, in addition to the specific role of these genes in ovarian differentiation.

  12. ZNRF3 binds RSPO1 and LGR5-RSPO1 with micromolar affinity via RSPO1 furin-like 1 (Fu1) domain.

  13. overexpressed in culture-activated hepatic stellate cells

  14. R-spondin1 (Rspo1) as a novel hormonal mediator in the mammary gland

  15. Findings indicate that R-spondin1 (Rspo1) is a negative regulator of beta-cell neogenesis and suggest that Rspo1 may serve as a therapeutic target for the preservation or restoration of functional [beta]-cells in diabetes.

  16. R-Spondin 1 is upregulated by mechanical signals and secreted. R-Spondin 1 promotes bone formation in three mouse models of osteoporosis.

  17. Wnt/Rspondin/beta-catenin signals control axonal sorting and lineage progression in Schwann cell development.

  18. In conclusion, present study highlights the role of Rspo 1 in bone remodeling where it activates Wnt signaling to induce differentiation, as shown in human as well murine in vitro osteoblast cell models.

  19. Rspo1 is an essential activator of ovarian development not only in normal situations, but also in sex reversal situations

Zebrafish R-Spondin 1 (RSPO1) interaction partners

  1. Rspo1 is required for hematopoietic stem cell specification through control of parallel signaling pathways controlling HSC specification: Wnt16/DeltaC/DeltaD and Vegfa/Tgfbeta1

  2. hypothesized that misexpression of R-Spondin1 is necessary for AHR activation to block regeneration (R-Spondin1)

  3. Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis.

  4. These preliminary findings suggest some aspects of RSPO1 like differential expression linked to sex determination may be conserved in fish while other aspects like subcellular localization differ from the mammalian RSPO1.

R-Spondin 1 (RSPO1) Antigen Profile

Protein Summary

This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.

Gene names and symbols associated with anti-R-Spondin 1 (RSPO1) Antibodies

  • R-spondin 1 (Rspo1) antibody
  • R-spondin 1 (RSPO1) antibody
  • R-spondin 1 (LOC100049655) antibody
  • R-spondin 1 (rspo1) antibody
  • CRISTIN3 antibody
  • R-spondin antibody
  • RGD1565558 antibody
  • RSPO antibody
  • Rspondin antibody
  • wu:fj81e05 antibody
  • zgc:92153 antibody

Protein level used designations for anti-R-Spondin 1 (RSPO1) Antibodies

R-spondin-1 , R-spondin homolog , roof plate-specific spondin-1 , R-spondin1 , cristin-3 , cysteine-rich and single thrombospondin domain-containing protein 3 , mCristin-3 , thrombospondin type 1 domain containing gene Rspondin , ovarian R-spondin member 1 , Roof plate-specific spondin-1 , cb1071 , fj81e05

GENE ID SPECIES
313589 Rattus norvegicus
100734447 Cavia porcellus
419613 Gallus gallus
284654 Homo sapiens
608179 Canis lupus familiaris
511675 Bos taurus
192199 Mus musculus
100860770 Capra hircus
100049655 Sus scrofa
436625 Danio rerio
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