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Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. Additionally we are shipping RAB1B, Member RAS Oncogene Family Antibodies (66) and many more products for this protein.
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Survival analysis indicates that patients with overexpression of Rab1B or MMP9 (show MMP9 Proteins) have significantly worse overall survival and progression-free survival, but better response to chemotherapy than those with low expression of proteins, and that Rab1B is an independent prognostic factor for colorectal cancer patients.
In these Rab1B-depleted cells, ATG9A (show ATG9A Proteins) accumulated in intermediate membrane structures at autophagosome formation sites. These results indicate that Rab1B is involved in regulating the proper development of autophagosomes.
Authors demonstrate that Rap1b (show RAP1B Proteins) expression is aberrantly increased in GC, resulting in the inhibition of autophagy and apoptosis of GC cells by the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) pathway.
RAB1B localization to the Golgi.
RAB1B acts as a metastasis suppressor in triple-negative breast cancer by regulating the TGF-beta (show TGFB1 Proteins)/SMAD (show SMAD1 Proteins) signaling pathway and RAB1B may serve as a biomarker of prognosis and response to anti-tumor therapeutics for patients with triple-negative breast cancer.
Our results show, for the first time, that changes in Rab1b levels modulate gene transcription and strongly suggest that a Rab1b increase is required to elicit a secretory response.
The crystal structure of the Rab1b-LepB complex.
results indicate that the cellular localization of MTMR6 (show MTMR6 Proteins) is regulated by Rab1B in the early secretory and autophagic pathways
The detailed molecular reaction mechanism of a complex between human Rab (show HRB Proteins) and RabGAP at the highest possible spatiotemporal resolution and in atomic detail, is described.
Rab1a/b and Rab43, are important for herpes simplex virus 1 virion assembly
Inhibition of PI3K or mTOR (show FRAP1 Proteins) reduced the level of Rap1B (show RAP1B Proteins), which acts downstream of Rheb (show RHEB Proteins) and mTOR (show FRAP1 Proteins). The ubiquitin E3 ligase Smurf2 (show SMURF2 Proteins) mediates the restriction of Rap1B (show RAP1B Proteins) by initiating its degradation.
Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997
ras-related protein Rab-1B
, small GTP-binding protein
, RAB1B, member RAS oncogene family
, ras-related protein Rab-1A
, RAB1B-like, member RAS oncogene family