anti-RAD18 Homolog (S. Cerevisiae) (RAD18) Antibodies

The protein encoded by RAD18 is highly similar to S. Additionally we are shipping RAD18 Proteins (6) and RAD18 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RAD18 56852 Q9NS91
RAD18 58186 Q9QXK2
RAD18 362412  
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Top anti-RAD18 Antibodies at antibodies-online.com

Showing 10 out of 114 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RAD18 Antibody Titration:  0.2-1 ug/ml  Positive Control:  721_B cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RAD18 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: COLO205 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IF, WB RAD18 monoclonal antibody (M03), clone 2B9. Western Blot analysis of RAD18 expression in Hela NE. Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) . Dilution: 1:500~1000 100 μg Log in to see 8 to 11 Days
$527.50
Details
Human Mouse Un-conjugated IF, IHC, WB Immunofluorescence of monoclonal antibody to RAD18 on HeLa cell (antibody concentration 25 µg/mL). Western blot analysis of RAD18 over-expressed 293 cell line, cotransfected with RAD18 Validated Chimera RNAi used as specificity and loading control. 100 μg Log in to see 8 to 11 Days
$527.50
Details
Human Mouse Un-conjugated IF, IHC (p), RNAi, ELISA, WB RAD18 monoclonal antibody (M01), clone 3H7 Western Blot analysis of RAD18 expression in Hela S3 NE . Immunofluorescence of monoclonal antibody to RAD18 on HeLa cell. [antibody concentration 25 ug/ml] 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Mouse Un-conjugated ELISA, FACS, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 2:Western blot analysis using RAD18 mAb against human RAD18 (AA: 332-430) recombinant protein. (Expected MW is 37.3 kDa) Dilution: 1/500 - 1/2000 100 μL Log in to see 8 to 11 Days
$577.50
Details
Human Rabbit Un-conjugated IP, WB Western blot analysis of RAD18 expression in MCF7 (A), A549 (B), Jurkat (C), HCT116 (D) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IP, PLA, WB Western Blot and Immunoprecipitation: RAD18 Antibody [ABIN253202] - Detection of Human RAD18 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) and 293T (T, 50 mcg) cells. Antibodies: Affinity purified rabbit anti- RAD18 antibody ABIN253202 used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. RAD18 was also immunoprecipitated by rabbit anti-RAD18 antibody ABIN253201, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 30 seconds Proximity Ligation Assay: RAD18 Antibody [ABIN2532023] - Secondary-conjugate Duolink II PLA in Hela cells. goat anti-human ATM (ABIN253202) and rabbit anti-human RAD18 (ABIN2532023). Image merged from DAPI (2ms) and Texas Red (200ms) exposures, 40X magnification. 0.1 mL Log in to see 7 to 9 Days
$559.35
Details
Human Rabbit Un-conjugated IF, IHC, WB 100 μL Log in to see 11 to 13 Days
$366.77
Details
Human Mouse Un-conjugated WB The anti-Rad18 mAb (Imgenex Cat#ABIN252484) was diluted at 2 ug/ml and tested against 20 ug of HL-60 cell lysate. 0.1 mg Log in to see 7 to 9 Days
$446.35
Details

Top referenced anti-RAD18 Antibodies

  1. Human Monoclonal RAD18 Primary Antibody for IF, IHC (p) - ABIN566046 : Hicks, Chute, Paulsen, Ragland, Howlett, Guéranger, Glover, Canman: Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links. in Molecular and cellular biology 2010 (PubMed)
    Show all 7 Pubmed References

  2. Mouse (Murine) Polyclonal RAD18 Primary Antibody for IF, IP - ABIN2452085 : Sun, Yomogida, Sakao, Yamamoto, Yoshida, Watanabe, Morita, Araki, Yamamura, Tateishi: Rad18 is required for long-term maintenance of spermatogenesis in mouse testes. in Mechanisms of development 2009 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal RAD18 Primary Antibody for IF, IP - ABIN2452086 : Tateishi, Sakuraba, Masuyama, Inoue, Yamaizumi: Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens. in Proceedings of the National Academy of Sciences of the United States of America 2000 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal RAD18 Primary Antibody for IP, PLA - ABIN253202 : Williams, Longerich, Sung, Vaziri, Kupfer: The E3 ubiquitin ligase RAD18 regulates ubiquitylation and chromatin loading of FANCD2 and FANCI. in Blood 2011 (PubMed)
    Show all 3 Pubmed References

  5. Human Monoclonal RAD18 Primary Antibody for WB - ABIN252484 : Lyakhovich, Shekhar: Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response. in Molecular and cellular biology 2003 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal RAD18 Primary Antibody for IP - ABIN253201 : Wagner, Karnitz: Cisplatin-induced DNA damage activates replication checkpoint signaling components that differentially affect tumor cell survival. in Molecular pharmacology 2009 (PubMed)

  7. Cow (Bovine) Polyclonal RAD18 Primary Antibody for WB - ABIN2774765 : Tsuji, Watanabe, Araki, Shinohara, Yamagata, Tsurimoto, Hanaoka, Yamamura, Yamaizumi, Tateishi: Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks. in Genes to cells : devoted to molecular & cellular mechanisms 2008 (PubMed)

  8. Human Polyclonal RAD18 Primary Antibody for WB - ABIN6146629 : Guo, He, Liu, Liang, Li, Cai, Lan, Zhou, Wang, Lei: Ablation of Ggnbp2 impairs meiotic DNA double-strand break repair during spermatogenesis in mice. in Journal of cellular and molecular medicine 2018 (PubMed)

More Antibodies against RAD18 Interaction Partners

Human RAD18 Homolog (S. Cerevisiae) (RAD18) interaction partners

  1. Long non-coding RNA ROR promotes radioresistance in hepatocelluar carcinoma cells by acting as a ceRNA for microRNA-145 to regulate RAD18 expression

  2. Data showed an inverse correlation between RAD18 protein expression and patient prognosis.

  3. Rad18, independently of its ubiquitin ligase activity, promotes DNA polymerase eta SUMOylation by facilitating its interaction with its SUMO ligase PIAS1 and is required for DNA polymerase eta function at difficult to replicate loci.

  4. MAGE-A4 depletion from MAGE-A4-expressing cancer cells destabilizes RAD18.

  5. Data suggest that, as part of DNA repair in nucleus of embryonic stem cells, IGF1R interacts with and phosphorylates PCNA at tyrosine residues 60, 133, and 250; this is followed by mono- and polyubiquitination of PCNA by RAD18 and SHPRH. (IGF1R = insulin-like growth factor 1 receptor; PCNA = proliferating cell nuclear antigen; RAD18 = E3 ubiquitin-protein ligase RAD18; SHPRH = E3 ubiquitin-protein ligase SHPRH)

  6. Ubiquitin ligases RNF168, RNF169, and RAD18 specifically bind histone H2A Lys13/15-ubiquitylated nucleosomes. 53BP1 chromatin recruitment may be activated by RNF168 and blocked by RNF169 and RAD18.

  7. WRNIP1 connects PCNA monoubiquitination with ATMIN/ATM to activate ATM signalling in response to replication stress and contribute to the maintenance of genomic stability.

  8. RAD18 polymorphisms are correlated with the side effects of platinum-chemotherapy in Chinese patients with advanced NSCLC.

  9. REV1 can promote PCNA monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18.

  10. USP7-mediated de-ubiquitylation protects Rad18 from proteasomal degradation and is necessary for the integrity of the specialized translesion synthesis pathway

  11. RAD18 can function as a mediator for DNA damage response signals to activate the G2/M checkpoint in order to maintain genome integrity and cell survival after IR exposure.

  12. Significantly restored tolerance of RAD18-/- and RNF8-/- cells to camptothecin and olaparib without affecting Rad51 focus formation.

  13. these results suggest that miR-145 can act as an RAD18 inhibitor and contribute as an important factor in reversing drug resistance after chemotherapy.

  14. We obtained a molecular envelope for Rad18 UBZ-ELRM:linear Ub2 polyubiquitin chains by small-angle X-ray scattering and derived a structural model for the complex.

  15. Rad18 protein ubiquitin-binding zinc fingers domain has alpha-helix and strand beta1 conformation.

  16. Monoubiquitination has a role in controlling Rad18 function.

  17. The Rad6/18 ubiquitin complex interacts with the Epstein-Barr virus deubiquitinating enzyme, BPLF1, and contributes to virus infectivity.

  18. HHR6 and hRad18 can monoubiquitinate FANCD2 at lysine 561 in vitro. This activity may represent a novel stress response pathway.

  19. Findings indicate that RAD18 may serve as a key mediator of the ionizing radiation (IR)response and may function as a potential target for circumventing IR resistance in glioblastoma multiforme (GBM).

  20. Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival.

Mouse (Murine) RAD18 Homolog (S. Cerevisiae) (RAD18) interaction partners

  1. Somatic hypermutation of immunoglobulin genes (SHM) in Rad18 KO mice was similar to wild-type mice, suggesting that Rad18 is dispensable for SHM.

  2. Rad18 confers DNA damage tolerance and tumor-suppression in a physiological setting.

  3. REV1 promote PCNA monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18.

  4. RAD18 can function as a mediator for DNA damage response signals to activate the G2/M checkpoint in order to maintain genome integrity and cell survival after IR exposure.

  5. repairs meiotic double-strand DNA breaks and and maintains meiotic sex chromosome inactivation

  6. RAD18 contributes to maintenance of genomic stability through postreplication repair

  7. Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase

  8. Rad18 suppresses viral infection in a non-specific fashion, probably by targeting incoming DNA.

  9. RAD18 is intrinsically required for the long-term maintenance of spermatogenesis.

RAD18 Antigen Profile

Protein Summary

The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.

Gene names and symbols associated with RAD18

  • RAD18, E3 ubiquitin protein ligase (RAD18) antibody
  • RAD18 E3 ubiquitin protein ligase (Rad18) antibody
  • RAD18 E3 ubiquitin protein ligase (rad18) antibody
  • E3 ubiquitin-protein ligase RAD18 (RAD18) antibody
  • E3 ubiquitin-protein ligase (RAD18) antibody
  • DNA repair protein and ATPase (RAD18) antibody
  • C3HC4-type zinc finger-containing protein (rad18) antibody
  • RAD18, E3 ubiquitin protein ligase (Rad18) antibody
  • 2810024C04Rik antibody
  • DDBDRAFT_0218120 antibody
  • DDBDRAFT_0304878 antibody
  • DDB_0218120 antibody
  • DDB_0304878 antibody
  • DKFZp469H0810 antibody
  • RAD18 antibody
  • Rad18sc antibody
  • RNF73 antibody
  • zgc:55577 antibody

Protein level used designations for RAD18

E3 ubiquitin-protein ligase RAD18 , RAD18, S. cerevisiae, homolog , RING finger protein 73 , hHR18 , hRAD18 , postreplication repair protein RAD18 , postreplication repair protein hRAD18p , mRAD18Sc , post-replication repair protein RAD18SC , RAD18 homolog (S. cerevisiae) , similar to postreplication repair protein hRAD18p , E3 ubiqutin ligase, forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair , Rad18p , hypothetical protein , DNA repair protein and ATPase , SAP DNA-binding domain-containing protein , RAD18 homolog , RAD18-like protein , E3 ubiquitin-protein ligase RAD18-like , e3 ubiquitin-protein ligase RAD18-like

GENE ID SPECIES
56852 Homo sapiens
58186 Mus musculus
362412 Rattus norvegicus
393106 Danio rerio
416114 Gallus gallus
460144 Pan troglodytes
476544 Canis lupus familiaris
514440 Bos taurus
704708 Macaca mulatta
850430 Saccharomyces cerevisiae S288c
3641637 Candida albicans SC5314
4839641 Scheffersomyces stipitis CBS 6054
8621702 Dictyostelium discoideum AX4
100052645 Equus caballus
100172537 Pongo abelii
100217383 Sus scrofa
100395032 Callithrix jacchus
100473633 Ailuropoda melanoleuca
100591424 Nomascus leucogenys
100720939 Cavia porcellus
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