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May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Additionally we are shipping RAD51AP1 Proteins (3) and and many more products for this protein.
Showing 10 out of 47 products:
Human Polyclonal RAD51AP1 Primary Antibody for IHC (p), IHC - ABIN249702
Parplys, Zhao, Sharma, Groesser, Liang, Maranon, Leung, Grundt, Dray, Idate, Østvold, Schild, Sung, Wiese: NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability. in Nucleic acids research 2015
Show all 2 Pubmed References
The current understanding of the biochemical and biological functions of RAD51AP1 as HR factor is reviewed. It is also discussed how RAD51AP1 may help to promote cancer development and potentially be a promising new target for therapeutic intervention. [REVIEW]
USP1 (show USP1 Antibodies)-UAF1 (show WDR48 Antibodies) complex promotes homologous recombination repair via multiple mechanisms: through FANCD2 (show FANCD2 Antibodies) deubiquitination, as well as by interacting with RAD51AP1.
RAD51AP1 is required for the maintenance of DNA replication fork progression.
Data suggest that microRNA/mRNA pairs in hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-140-3p/RAD51AP1/, hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-145/E2F3, hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-139-5p/TOP2A (show TOP2A Antibodies), and hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-133a/GCLC (show GCLC Antibodies) were correlated with ovarian tumorigenesis.
We have finely mapped the two DNA binding domains in RAD51AP1 and using mutant variants, reveal that both domains are indispensable for RAD51AP1 function in cells.
RAD51-associated protein 1 (RAD51AP1) interacts with the meiotic recombinase (show RAG1 Antibodies) DMC1 (show DMC1 Antibodies) through a conserved motif.
RAD51AP1 foci colocalize with a subset of DMC1 (show DMC1 Antibodies) foci in spermatocytes.
Although PALB2 (show PALB2 Antibodies) alone stimulates D-loop formation, it has a cooperative effect with RAD51AP1, an enhancer of RAD51 (show RAD51 Antibodies).
expression of three (Beclin 1 (show BECN1 Antibodies), RbAp48 (show RBBP4 Antibodies) and Pir51) were increased and one (aldolase b (show ALDOB Antibodies)) was decreased in liver tumor tissues
RAD51AP1 has a selective affinity for branched-DNA structures that are obligatory intermediates during joint molecule formation.
VipD of Legionella pneumophila targets activated Rab5 (show RAB5A Antibodies) and Rab22 to interfere with endosomal trafficking in macrophages.
May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Functionally cooperates with PALB2 in promoting of D-loop formation by RAD51. Binds to single and double stranded DNA, and is capable of aggregating DNA. Also binds RNA (By similarity).
RAD51-associated protein 1
, RAD51-interacting protein