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The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010].. Additionally we are shipping RAP1GDS1 Antibodies (54) and RAP1GDS1 Proteins (4) and many more products for this protein.
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a novel nuclear role for SmgGDS in protecting malignant cells from nucleolar stress, thus promoting cell cycle progression and tumorigenesis.
Data suggest that SmgGDS-558 splice variant exhibits a fold containing tandem copies of armadillo (show PKP1 ELISA Kits)-repeat motifs not present in other guanine nucleotide exchange factors (GEFs); SmgGDS harbors distinct positively and negatively charged regions, both of which play critical roles in binding to RhoA (show RHOA ELISA Kits) and in GEF activity. (SmgGDS = smg (show SNRPG ELISA Kits) p21 (show CDKN1A ELISA Kits) stimulatory GDP exchange protein; RhoA (show RHOA ELISA Kits) = ras homolog gene family, member A (show CXCL14 ELISA Kits))
Unlike Rap1B (show RAP1B ELISA Kits), phosphorylation in the polybasic region of Rap1A (show RAP1A ELISA Kits) does not detectably inhibit its prenylation or its binding to SmgGDS-607.
In addition, a PINK1 mutant, which induced mitochondrial enlargement and had been considered as a Drosophila model of Parkinson's disease (PD), caused fly muscle defects, and the loss of vimar could rescue these defects. Furthermore, we found that the mammalian homolog of Vimar, RAP1GDS1, played a similar role in regulating mitochondrial morphology, suggesting a functional conservation of this GEF member.
results indicate that statins selectively up-regulate SmgGDS in endothelial cells, for which the beta1-integrin/Akt1 (show AKT1 ELISA Kits) pathway may be involved, demonstrating the novel aspects of the pleiotropic effects of statins
DiRas1 (show DIRAS1 ELISA Kits) expression inhibits malignant features of cancers in part by nonproductively binding to SmgGDS and inhibiting the binding of other small GTPases to SmgGDS
SmgGDS promotes cell cycle progression in multiple types of cancer, making SmgGDS a valuable target for cancer therapeutics.
TG2 (show TGM2 ELISA Kits) contributes to apoptosis induction in Jurkat T cells by modulating Ca2 (show CA2 ELISA Kits)+ homeostasis via cross-linking RAP1GDS1.
findings identify SmgGDS-558 as an activator of RhoA (show RHOA ELISA Kits) and NF-kB in breast cancer, and demonstrate a functional role for SmgGDS-558 in the proliferation of breast cancer cells and tumorigenesis.
this study provides evidence that SmgGDS-607 associates with GTPases through recognition of the last amino acid in the CAAX motif.
These results identify SmgGDS as a novel regulator of myosin organization and contraction in vascular smooth muscle cells.
These results indicate that statins exert their pleiotropic effects through SmgGDS upregulation with a resultant Rac1 degradation and reduced oxidative stress in animals and humans.
The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993
rap1 GTPase-GDP dissociation stimulator 1
, RAP1, GTP-GDP dissociation stimulator 1
, SMG GDS protein
, SMG P21 stimulatory GDP/GTP exchange protein
, exchange factor smgGDS
, ralB-binding protein A
, rap1 GTPase-GDP dissociation stimulator 1-A