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RAP1GAP encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Additionally we are shipping RAP1 GTPase Activating Protein Antibodies (36) and RAP1 GTPase Activating Protein Proteins (4) and many more products for this protein.
a proper level of Rap1 is crucial for heart morphogenesis and function.
the direct interaction between Rap1 and KRIT1 is required for KRIT1 (show TERF2IP ELISA Kits)function in (show KRIT1 ELISA Kits) cardiovascular development
results have shown a novel role of PLCepsilon in the maintenance of endothelial barrier function, via its CDC25 GEF domain and lipase activity, and subsequent up-regulation of Rap1 activity
Findings suggest that RAP1 GTPase activating protein (Rap1GAP) is an important tumor suppressor with high prognostic value in endometrioid adenocarcinoma (EAC (show CYLD ELISA Kits)).
Rap1GAP is ubiquitinated and degraded through proteasome pathway in mitosis. Rap1GAP interacts with PLK1 (show PLK1 ELISA Kits) in vivo.
this study demonstrates that USP48 (show USP48 ELISA Kits) controls the Ubiquitin/proteasome-system-dependent turnover of activated NF-kappaB (show NFKB1 ELISA Kits)/RelA (show NFkBP65 ELISA Kits) in the nucleus.
Northern blot analysis revealed a single USP31 transcript of approximately 4 kb, which was primarily expressed in the testis and lung.
The Overexpression of USP31 in HEK (show EPHA3 ELISA Kits) 293T cells inhibited TNFalpha (show TNF ELISA Kits), CD40 (show CD40 ELISA Kits), LMP1 (show PDLIM7 ELISA Kits), TRAF2 (show TRAF2 ELISA Kits), TRAF6 (show TRAF6 ELISA Kits) and IKKbeta (show IKBKB ELISA Kits)-mediated NF-kappaB (show NFKB1 ELISA Kits) activation, but did not inhibit Smad (show SMAD1 ELISA Kits)-mediated transcription activation.
kidney biopsies from glomerulosclerosis patients exhibited increased RAP1GAP, resulting in diminished glomerular RAP1 activation
data demonstrate a crucial role for the dynamic interaction between D3R and USP48 (show USP48 ELISA Kits) in the regulation of NHE3 (show SLC9A3 ELISA Kits) expression and function
findings identify Rap1GAP as a critical regulator of aggressive tumor cell behavior and suggest that the level of Rap1GAP expression influences the migratory mechanisms that are operative in tumor cells.
Results demonstrated that Rap1GAP promoted leukemia cell differentiation and apoptosis, but increased leukemia cell invasion in vitro.
increased podocyte expression of RAP1GAP contributes directly to podocyte dysfunction by a mechanism that involves loss of RAP1-mediated activation of beta1 integrin
Plexins are GTPase (show RACGAP1 ELISA Kits)-activating proteins for Rap (show LRPAP1 ELISA Kits) and are activated by induced dimerization
Ca2 (show CA2 ELISA Kits)+-dependent monomer and dimer formation switches CAPRI (show RASA4 ELISA Kits) Protein between Ras GTPase-activating protein (show RASA1 ELISA Kits) (GAP) and RapGAP activities
ERK activation by cAMP does not require RAP1
evidence of differential Krit1 (show KRIT1 ELISA Kits) and Rap1A (show RAP1A ELISA Kits) expression during mouse ontogenesis and suggest a more widespread functional significance of Krit1 (show KRIT1 ELISA Kits), not restricted to vascular endothelial cells.
Rap1 (show TERF2IP ELISA Kits) couples cAMP signaling to a distinct pool of p42 (show EPB42 ELISA Kits)/44MAPK regulating excitability, synaptic plasticity, learning, and memory.
Expression studies show that mr-gef (show RAPGEF5 ELISA Kits) is expressed by young neurons of the developing rodent CNS but not by progenitor cells in the ventricular zone (VZ).
down-regulation of Rap1 (show TERF2IP ELISA Kits) expression following somatostatin (show SST ELISA Kits) treatment is closely related to the diminished LFA-1 (show ITGAL ELISA Kits) expression
forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB (show CREB ELISA Kits)) and Epac1 (show RAPGEF3 ELISA Kits)-Rap1 (show TERF2IP ELISA Kits) signaling
EGF (show EGF ELISA Kits)-induced activation of GTPase (show RACGAP1 ELISA Kits) Rap1 (show TERF2IP ELISA Kits) was sensitized in NIH3T3/EGFR (show EGFR ELISA Kits)-e3B1 (show ABI1 ELISA Kits) cells.
This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins.
rap1 GTPase-activating protein 1
, Rap1, GTPase-activating protein 1
, GTPase activating protein 1
, GTPase activating protein Rap1-GAP
, RAP1, GTPase activating protein 1
, Rap1 GTPase-activating protein 1