RalA Binding Protein 1 Proteins (RALBP1)

Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Additionally we are shipping RALBP1 Antibodies (135) and RALBP1 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RALBP1 19765 Q62172
RALBP1 84014 Q62796
RALBP1 10928 Q15311
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Top RALBP1 Proteins at antibodies-online.com

Showing 7 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$778.00
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$888.80
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Escherichia coli (E. coli) Mouse His tag   100 μg Log in to see 15 to 18 Days
$800.00
Details
Escherichia coli (E. coli) Rat His tag   100 μg Log in to see 15 to 18 Days
$816.00
Details

RALBP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Rat (Rattus)

Human , , ,
, ,

More Proteins for RalA Binding Protein 1 (RALBP1) Interaction Partners

Mouse (Murine) RalA Binding Protein 1 (RALBP1) interaction partners

  1. Rlip deficiency suppresses spontaneous malignancy in p53(-/-) mice.

  2. The results show that ARNO interaction with the RLIP76 N-terminus regulates cell spreading and motility via PI3K and Arf6, independent of RLIP76 control of Rac.

  3. RLIP76 acts as a scaffold at recycling endosomes by binding activated R-Ras, recruiting ARNO to activate Arf6, thereby contributing to cell spreading and migration.

  4. The expression of Hsf4b known to be involved in lens development is down regulated in the lens of these Tg mice.

  5. a fundamental role of RLIP76 in regulating the function of obesity-promoting pro-inflammatory cytokines

  6. RalBP1 is a gene regulating the seizure threshold and synaptic inhibition in mice

  7. results establish that RLIP76 is required for efficient endothelial cell function and angiogenesis in solid tumors

  8. RLIP76 represents a mechanistically significant target for developing effective interventions in aggressive and refractory pancreatic cancers

  9. Studies confirmed a model in which RLIP76 plays a central role in the pathogenesis of metabolic syndrome and RLIP76 loss causes profound and global alterations of MSy signaling functions.

  10. Findings show a fundamental role of RLIP76 in chemical carcinogenesis.

  11. Because RLIP76 is induced by oxidative stress, it could play a role in insulin resistance seen in pathological conditions characterized by increased oxidative stress

  12. Data show that RLIP76 knockout mice are extremely sensitive to irradiation.

  13. role in regulating endocytosis of activin type II receptors by ARIP2

  14. RIP1 may mediate the p38 MAP kinase response to TNF-alpha, by recruiting the MAP3K MEKK3.

  15. Poly(ADP-ribose)polymerase-1 signaling to mitochondria in necrotic cell death requires Rip1-mediated JNK1.

  16. Thus, we identify a novel R-Ras effector, RLIP76, which links R-Ras to adhesion-induced Rac activation through a GTPase cascade that mediates cell spreading and migration.

  17. The active caspase-8c-FLIP complex forms in the absence of Fas (CD95/APO1) and associates with the NF-kappaB signaling molecules RIP1, TRAF2, and TRAF6, as well as upstream NF-kappaB regulators PKC theta, CARMA1, Bcl-10, and MALT1

  18. MFG-E8 mRNA and protein are increased in angiogenic islets and tumors in Rip1-Tag2 mice compared with normal pancreas

  19. Loss of RLIP76 confers sensitivity to xenobiotics and radiation due to the loss of a common transport mechanism for glutathione-electrophile conjugates and xenobiotics.

Human RalA Binding Protein 1 (RALBP1) interaction partners

  1. RLIP76 plays a critical role in cellular proliferation, apoptosis, cell cycle distribution, cell movement and invasion in melanoma

  2. In the exons and exon-intron boundaries of ABCB5 and RLIP76 genes.

  3. the miR143-3p level was markedly lower in participants with ovarian cancer compared with normal control, while the expression of RALBP1 mRNA and protein were evidently overexpressed in participants with ovarian cancer compared with normal control.

  4. RLIP76 knockdown increased autophagic flux and apoptosis in U251 glioma cells.

  5. Phosphorylation level of Akt declined from 138.45+/-13.8 to 69.9+/-29.7% in SGC-7901, and from 115.5+/-26.6 to 49.07+/-27% in MGC-803 and phosphorylation level of mTOR also significantly decreased.While apoptosis of gastric cancer(GA) cells increased which we verified with apoptosis proteins and staining analysis. Our data showed that RLIP76 plays a significant oncogenic role in GC and it maybe a potential target in GC

  6. Anti-tumor effect was exerted when miR-124 directly targeted RLIP76, a stress-inducible transporter that plays a crucial role in the development of melanoma.

  7. report showed that RLIP76 expression was significantly increased in breast cancer samples and positively correlated with the malignant status of breast cancer patients; results indicated that high RLIP76 expression was associated with poor prognosis of breast cancer patients

  8. RLIP76 expression is induced by TNF-alpha and follows the induction kinetics of inflammation markers, suggesting that inflammation can influence RLIP76 expression at the blood brain barrier.

  9. RLIP76 downregulation in HT29 CRC cells suppressed cell growth, enhanced cell apoptosis, induced cell cycle arrest, and inhibited cell invasion by decreasing MMP2 expression.

  10. High RLIP76 expression is associated with a poor outcome of meningioma.

  11. results revealed that the effect of miR-101 on prostate cancer cell apoptosis was due to RLIP76 regulation of the PI3K/Akt/Bcl-2 signaling pathway

  12. RalBP1 protein is an independent predictor of poor survival and early relapse for CRC patients

  13. RLIP76 is a potential target for developing novel therapeutic strategies for leukemia

  14. RLIP76 is a node for Rho and Ras family signalling. [Review]

  15. Activation of RalBP1 during neoplastic epithelial cell transformation induces cytoplasmic accumulation of p27, this event requires p27 Ser-10 phosphorylation by protein kinase B/Akt.

  16. RLIP76 may suppress apoptosis and promote the proliferation of glioma cells by direct adenosine triphosphate-dependent xenobiotic transport and by activating the Rac1-JNK signaling pathway.

  17. p300 associates with the RLIP76 promoter via an overlapping cMYB and cETS binding site and regulates RLIP76 promoter activity and its expression.

  18. RalB-mediated invadopodium formation was dependent on RalBP1/RLIP76; disruption of the ATPase function of RalBP1 impaired invadopodium formation.

  19. The impairment of RLIP76 by aaRLIP76 can play a role in the damage of vascular cells from females, contributing to the gender-associated pathogenesis of immune-mediated vascular diseases.

  20. Data show that disrupting either RALA or RALBP1 leads to a loss of mitochondrial fission at mitosis, improper segregation of mitochondria during cytokinesis and a decrease in ATP levels and cell number.

RALBP1 Protein Profile

Protein Summary

Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin (By similarity).

Gene names and symbols associated with RALBP1

  • ralA binding protein 1 S homeolog (ralbp1.S)
  • ralA binding protein 1 (RALBP1)
  • ralA binding protein 1 (ralbp1)
  • ralA binding protein 1 (Ralbp1)
  • RALBP1 protein
  • RIP1 protein
  • rlip-A protein
  • RLIP1 protein
  • RLIP76 protein

Protein level used designations for RALBP1

ralA binding protein 1 , Ral interacting protein , ralA-binding protein 1 , ralA-binding protein 1-like , DNP-SG ATPase , Ral-interacting protein 1 , dinitrophenyl S-glutathione ATPase , cytocentrin , ral-interacting protein 1 , 76 kDa Ral-interacting protein

GENE ID SPECIES
394288 Xenopus laevis
429466 Gallus gallus
455292 Pan troglodytes
523324 Bos taurus
100379815 Xenopus (Silurana) tropicalis
100431225 Pongo abelii
100478485 Ailuropoda melanoleuca
100519155 Sus scrofa
100549203 Meleagris gallopavo
100557384 Anolis carolinensis
100600679 Nomascus leucogenys
19765 Mus musculus
84014 Rattus norvegicus
10928 Homo sapiens
490548 Canis lupus familiaris
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