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Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Additionally we are shipping RALBP1 Antibodies (139) and RALBP1 Kits (10) and many more products for this protein.
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Affects dynamics of the actin cytoskeleton, signalling from Ral (show rala Proteins) to RLIP is required for gastrulation.
These results demonstrate that to participate in the control of the actin cytoskeleton, RLIP needs its complete N-terminal region coding for the mu2BD and the GAP domain.
The results show that ARNO (show CYTH2 Proteins) interaction with the RLIP76 N-terminus regulates cell spreading and motility via PI3K and Arf6 (show ARF6 Proteins), independent of RLIP76 control of Rac (show AKT1 Proteins).
RLIP76 acts as a scaffold at recycling endosomes by binding activated R-Ras, recruiting ARNO (show CYTH2 Proteins) to activate Arf6 (show ARF6 Proteins), thereby contributing to cell spreading and migration.
a fundamental role of RLIP76 in regulating the function of obesity-promoting pro-inflammatory cytokines
RalBP1 is a gene regulating the seizure threshold and synaptic inhibition in mice
results establish that RLIP76 is required for efficient endothelial cell function and angiogenesis in solid tumors
RLIP76 represents a mechanistically significant target for developing effective interventions in aggressive and refractory pancreatic cancers
Studies confirmed a model in which RLIP76 plays a central role in the pathogenesis of metabolic syndrome and RLIP76 loss causes profound and global alterations of MSy signaling functions.
Findings show a fundamental role of RLIP76 in chemical carcinogenesis.
Because RLIP76 is induced by oxidative stress, it could play a role in insulin (show INS Proteins) resistance seen in pathological conditions characterized by increased oxidative stress
Data show that RLIP76 knockout mice are extremely sensitive to irradiation.
RLIP76 plays a critical role in cellular proliferation, apoptosis, cell cycle distribution, cell movement and invasion in melanoma
In the exons and exon-intron boundaries of ABCB5 (show ABCB5 Proteins) and RLIP76 genes.
the miR143-3p level was markedly lower in participants with ovarian cancer compared with normal control, while the expression of RALBP1 mRNA and protein were evidently overexpressed in participants with ovarian cancer compared with normal control.
RLIP76 knockdown increased autophagic flux and apoptosis in U251 glioma cells.
Phosphorylation level of Akt (show AKT1 Proteins) declined from 138.45+/-13.8 to 69.9+/-29.7% in SGC (show SGCB Proteins)-7901, and from 115.5+/-26.6 to 49.07+/-27% in MGC-803 and phosphorylation level of mTOR (show FRAP1 Proteins) also significantly decreased.While apoptosis of gastric cancer(GA) cells increased which we verified with apoptosis proteins and staining analysis. Our data showed that RLIP76 plays a significant oncogenic role in GC and it maybe a potential target in GC
Anti-tumor effect was exerted when miR (show MLXIP Proteins)-124 directly targeted RLIP76, a stress-inducible transporter that plays a crucial role in the development of melanoma.
report showed that RLIP76 expression was significantly increased in breast cancer samples and positively correlated with the malignant status of breast cancer patients; results indicated that high RLIP76 expression was associated with poor prognosis of breast cancer patients
RLIP76 expression is induced by TNF-alpha (show TNF Proteins) and follows the induction kinetics of inflammation markers, suggesting that inflammation can influence RLIP76 expression at the blood brain barrier.
RLIP76 downregulation in HT29 CRC (show CALR Proteins) cells suppressed cell growth, enhanced cell apoptosis, induced cell cycle arrest, and inhibited cell invasion by decreasing MMP2 (show MMP2 Proteins) expression.
High RLIP76 expression is associated with a poor outcome of meningioma.
Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin (By similarity).
ralA binding protein 1
, Ral interacting protein
, ralA-binding protein 1
, ralA-binding protein 1-like
, DNP-SG ATPase
, Ral-interacting protein 1
, dinitrophenyl S-glutathione ATPase
, ral-interacting protein 1
, 76 kDa Ral-interacting protein