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Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development.. Additionally we are shipping Radil Proteins (3) and and many more products for this protein.
Showing 10 out of 42 products:
Mouse (Murine) Polyclonal Radil Primary Antibody for WB - ABIN2780158
Nishimura, Mitne-Neto, Silva, Oliveira, Vainzof, Zatz: A novel locus for late onset amyotrophic lateral sclerosis/motor neurone disease variant at 20q13. in Journal of medical genetics 2004
Show all 2 Pubmed References
Here, we identify a novel effector of the small GTPase (show RACGAP1 Antibodies) Rap (show LRPAP1 Antibodies), called RADIL, and show that it is required for cell adhesion and migration
Studies indicate that Radil regulates neutrophil adhesion and motility by linking Rap1 to beta2-integrin activation. +++ ERROR +++ studies establish that Radil regulates neutrophil adhesion and motility by linking Rap1 to beta2-integrin activation.
It was shown that KIF14 (show KIF14 Antibodies) associates with the PDZ domain (show INADL Antibodies) of Radil and negatively regulates Rap1 (show RABGEF1 Antibodies)-mediated inside-out integrin activation by tethering Radil on microtubules. Radil is also important for breast cancer cell proliferation and metastasis.
Gbetagamma subunits enter in a protein complex with activated Rap1a (show RAP1A Antibodies) and its effector Radil; this complex is required downstream of receptor stimulation for the activation of integrins and the positive modulation of cell-matrix adhesiveness.
Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development.
ras-associating and dilute domain-containing protein
, Rap GTPase interactor
, Ras association and DIL domains
, ras-associating and dilute domain-containing protein-like
, Rap GTPase interactor, RADIL