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The protein encoded by RREB1 is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters.
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RREB1 cooperates with noncoding RNA linc-ADAMTS5 (show ADAMTS5 ELISA Kits) to inhibit ADAMTS5 (show ADAMTS5 ELISA Kits) expression, thereby affecting degeneration of the extracellular matrix (ECM (show MMRN1 ELISA Kits)) of the intervertebral disc.
RREB1 and CCND1 (show CCND1 ELISA Kits) gains are common in nail (show CD244 ELISA Kits) apparatus melanoma
Histone modifier genes (JMJD1C, RREB1, MINA, KDM7A) alter conotruncal heart phenotypes in 22q11.2 deletion syndrome.
RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease.
The pathway of RREB1/ZIP3 (show SLC39A3 ELISA Kits)/Zinc and its downregulation during oncogenesis exist to prevent the accumulation of cytotoxic levels of zinc during the development and progression of the malignant cells in pancreatic adenocarcinoma.
RREB-1 overexpression results in down-regulation of hZIP1 (show SLC39A1 ELISA Kits) and contributes to the loss of hZIP1 (show SLC39A1 ELISA Kits) expression and zinc in prostate cancer.
Thus HNT (show NTM ELISA Kits) and c are functional homologs at the level of DNA binding, transcriptional regulation and developmental control
Data show the transcriptional activation of the cholecystokinin (show CCK ELISA Kits) gene by DJ-1 (show PARK7 ELISA Kits) through interaction of DJ-1 (show PARK7 ELISA Kits) with RREB1 and the effect of DJ-1 (show PARK7 ELISA Kits) on the cholecystokinin (show CCK ELISA Kits) level.
RREB1 is overexpressed in colorectal adenocarcinoma tumors. RREB1 repressed miR-143/145 modulates KRAS signaling.
These results support a concept that downregulation of RREB-1 causes downregulation of ZIP3 (show SLC39A3 ELISA Kits), which results in decreased zinc in pancreatic premalignant and carcinoma cells
The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene.
, finger protein in nuclear bodies
, hindsight homolog
, raf-responsive zinc finger protein LZ321
, ras-responsive element-binding protein 1
, zinc finger motif enhancer binding protein 1
, zinc finger motif enhancer-binding protein 1
, zinc finger motif-enhancer binding-protein 1
, RAS-responsive zinc finger transcription factor RREB
, Ras-responsive element binding protein 1
, transcription factor RREB-1
, ras responsive element binding protein 1
, ras-responsive element-binding protein 1-like