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RFXANK encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Additionally we are shipping Regulatory Factor X-Associated Ankyrin Containing Protein Antibodies (68) and Regulatory Factor X-Associated Ankyrin Containing Protein Proteins (7) and many more products for this protein.
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Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity.
DNA-binding protein RFXANK
, ankyrin repeat family A protein 1
, ankyrin repeat-containing regulatory factor X-associated protein
, regulatory factor X subunit B
, ankyrin repeat-containing adapter protein Tvl-1