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Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication. Additionally we are shipping REPIN1 Kits (20) and REPIN1 Antibodies (14) and many more products for this protein.
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Results show that breast cancer cells underwent epithelial-mesenchymal transition when AP4 was upregulated, and that AP4 regulated p53 (show TP53 Proteins) expression level suggesting AP4 can regulate cell migration via the activity of p53 (show TP53 Proteins).
AP4 is transcriptionally activated by TGFB1 (show TGFB1 Proteins) to inhibit phosphorylation of SMAD2 (show SMAD2 Proteins) as a negative regulator of an activated TGFB (show TGFB1 Proteins) receptor signaling on cell growth inhibition in non-small cell lung cancer
there is a p53 (show TP53 Proteins)-induced double-negative feedback loop involving miR (show MLXIP Proteins)-15a/16-1 and AP4 that stabilizes epithelial and mesenchymal states, respectively, which may determine metastatic prowess in colorectal cancer
a potential role for Repin1 as regulator of adipocyte size was shown.Repin1 seems to be involved in the regulation of genes involved in adipogenesis.
AP4 and geminin act as a repressor complex distinct from REST/NRSF to negatively regulate the expression of target genes in nonneuronal cells.
Our study provides evidence that loss of Repin1 in db/db (show LEPR Proteins) mice improves insulin (show INS Proteins) sensitivity and reduces chronic hyperglycemia most likely by reducing fat mass and AT inflammation.
Our findings indicate that Repin1 plays a role in insulin (show INS Proteins) sensitivity and lipid metabolism by regulating key genes of glucose and lipid metabolism.
Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication. Binds on 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation situated within the OBR zone. Facilitates DNA bending (By similarity).
60 kDa origin-specific DNA-binding protein
, 60 kDa replication initiation region protein
, ATT-binding protein
, DHFR oribeta-binding protein RIP60
, replication initiation region protein (60kD)
, zinc finger protein 464 (RIP60)
, zinc finger protein AP4
, replication initiator 1
, replication initiator 1-like
, LOW QUALITY PROTEIN: replication initiator 1