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Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER.
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Human Polyclonal RCN1 Primary Antibody for IHC (p), IP - ABIN438271
Cui, Dougherty, Machacek, Sawchuk, Hochman, Baro: Divergence between motoneurons: gene expression profiling provides a molecular characterization of functionally discrete somatic and autonomic motoneurons. in Physiological genomics 2006
In the adult mice, RCAN1 (show RCAN1 Antibodies) was mainly expressed in the neuropil throughout the brain.
RCN1 (show RCAN1 Antibodies) may promote cell survival and serve as a useful target for cancer therapy.
irradiated tumor cells were observed to significantly up-regulate the expression of calcium-binding proteins CALM1, CALU (show CALU Antibodies), and RCN1 (show RCAN1 Antibodies), suggesting important roles for these mediators in promoting tumor cell survival during hypoxia
RCN1 (show RCAN1 Antibodies) expression was not statistically significantly different to healthy controls but was associated with disease activity score and could be used as a stratification biomarker for systemic sclerosis patients.
reticulocalbin-1 plays a key role in the development of doxorubicin-associated resistance
Ca(2 (show CA2 Antibodies)+) binding caused an increase in the alpha-helix content of human RCN1 (show RCAN1 Antibodies). On the other hand, RCN1 (show RCAN1 Antibodies) did not change the structure with Mg.
a promising role of RCN1 (show RCAN1 Antibodies) as a possible marker in Renal cell carcinoma (show MOK Antibodies)
reticulocalbin-1 may be an important molecule in understanding lymphatic endothelial cells in tumors function and control of lymphatic metastasis.
Increased RCN1 (show RCAN1 Antibodies) is associated with systemic sclerosis and nephrogenic systemic fibrosis.
deletion of Rcn1 (show RCAN1 Antibodies) directly or indirectly contributes to the eye phenotype in Pax6 (show PAX6 Antibodies) contiguous gene deletions
RCN1 (show RCAN1 Antibodies) also is expressed on the cell surface of several endothelial cell lines, including human dermal microvascular endothelial cells (HDMVECs), bone marrow endothelial cells (BMEC), and transformed human bone marrow endothelial cells (TrHBMEC).
Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane.
, proliferation-inducing gene 20