SET and MYND Domain Containing 2 (SMYD2) ELISA Kits

SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).[supplied by OMIM, Nov 2008].. Additionally we are shipping SET and MYND Domain Containing 2 Antibodies (85) and SET and MYND Domain Containing 2 Proteins (12) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
SMYD2 56950 Q9NRG4
Anti-Mouse SMYD2 SMYD2 226830 Q8R5A0
Anti-Rat SMYD2 SMYD2 289372 Q7M6Z3
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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 6.25 pg/mL 25-1600 pg/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$910.56
Details

More ELISA Kits for SET and MYND Domain Containing 2 Interaction Partners

Human SET and MYND Domain Containing 2 (SMYD2) interaction partners

  1. Lysine methylation represses p53 activity in teratocarcinoma cancer cells via up-regulation of SMYD2 and PR-Set7 and perpetuation of cancer cells proliferation.

  2. SMYD2-H4K20me1-L3MBTL1 axis contributes to HIV-1 latency and can be targeted with small-molecule SMYD2 inhibitors.

  3. identifie novel cellular substrates of the lysine methyltransferase SMYD2. Of the 14 novel putative SMYD2 substrates identified, six were confirmed in cells by immunoprecipitation: MAPT (show MAPT ELISA Kits), CCAR2, EEF2 (show EEF2 ELISA Kits), NCOA3 (show NCOA3 ELISA Kits), STUB1 (show STUB1 ELISA Kits), and UTP14A. Treatment with the selective SMYD2 inhibitor BAY-598 abrogated the methylation signal, indicating that methylation of these novel substrates was dependent on the catalytic activity of SMYD2

  4. The SMYD2 may promote BMP signaling by directly methylating BMPR2, which, in turn, stimulates BMPR2 kinase activity and activation of the BMP pathway.

  5. Knockdown of SMYD2 as well as treatment with a SMYD2 inhibitor in two NSCLC cell lines with an EML4-ALK gene significantly attenuated the phosphorylation levels of the EML4-ALK protein.

  6. SMYD2 knockdown confers relative resistance to human AML (show RUNX1 ELISA Kits) cells against multiple classes of DNA damaging agents.

  7. Substrate crevices of Smyd2 and Smyd3 show distinct features in terms of spatial, hydration, and electrostatic properties that emphasize their characteristic modes of substrates interaction and entry pathways for inhibitor binding.

  8. High expression of SMYD2 is associated with chronic lymphocytic leukemia.

  9. Study reveals a collection of 10 enriched sequence motifs in Kme1 sites that were identified upon SMYD2 overexpression which were also downregulated in response to SMYD2 knockdown. These findings suggest that these motifs reflect the substrate specificity of SMYD2 in esophageal squamous cell carcinoma cell line.

  10. Results show that high expression levels of SMYD2, SETD3, and NO66 in renal cell tumors. Their low expression levels were significantly associated with shorter disease-specific and disease-free survival.

Mouse (Murine) SET and MYND Domain Containing 2 (SMYD2) interaction partners

  1. Our data indicate that Smyd2 has a critical role downstream of Myc (show MYC ELISA Kits) in acute myeloid leukemia (show BCL11A ELISA Kits)

  2. two positive feedback loops that integrate epigenetic regulation and renal inflammation in cyst development: SMYD2/IL-6 (show IL6 ELISA Kits)/STAT3 (show STAT3 ELISA Kits)/SMYD2 and SMYD2/TNF-alpha (show TNF ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits)/SMYD2.

  3. a pivotal role for SMYD2 in promoting pancreatic cancer.

  4. Data show that histone methyltransferase Smyd2 inhibits macrophage interleukin 6 (IL-6 (show IL6 ELISA Kits)) and tumor necrosis factor alpha (TNF-alpha (show TNF ELISA Kits)) production. production.

  5. Smyd2 is a lysine methyltransferase which has, next to its nuclear activity, specific regulatory functions in the cytoplasm of heart and skeletal muscle cells.

  6. Smyd2, similar to Smyd3, interacts with RNA Polymerase II as well as to the RNA helicase, HELZ (show HELZ ELISA Kits)

  7. Sin3A (show SIN3A ELISA Kits)-mediated deacetylation within the coding regions of active genes is directly linked to the histone methyltransferase activity of Smyd2 [Symd2]

  8. results show that Smyd2 negatively regulates p53 (show TP53 ELISA Kits)-responsive genes in a p53 (show TP53 ELISA Kits)-dependent manner

Zebrafish SET and MYND Domain Containing 2 (SMYD2) interaction partners

  1. Findings suggest that SMYD2 (SET and MYND domain containing protein 2), a histone lysine methyltransferase, plays a critical role at early stages of development.

SET and MYND Domain Containing 2 (SMYD2) Antigen Profile

Antigen Summary

SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006

Gene names and symbols associated with SMYD2

  • SET and MYND domain containing 2 (SMYD2) antibody
  • SET and MYND domain containing 2 (Smyd2) antibody
  • SET and MYND domain containing 2 S homeolog (smyd2.S) antibody
  • SET and MYND domain containing 2a (smyd2a) antibody
  • SET and MYND domain containing 2b (smyd2b) antibody
  • 1110020E07Rik antibody
  • 4930402C15 antibody
  • HSKM-B antibody
  • im:7146196 antibody
  • KMT3C antibody
  • si:dkey-121j17.3 antibody
  • smyd2 antibody
  • smyd2-a antibody
  • wu:fc02f02 antibody
  • zgc:110553 antibody
  • zgc:136609 antibody
  • Zmynd14 antibody

Protein level used designations for SMYD2

N-lysine methyltransferase SMYD2 , SET and MYND domain-containing protein 2 , histone methyltransferase SMYD2 , lysine N-methyltransferase 3C , zinc finger, MYND domain containing 14 , HSKM-B protein , Histone methyltransferase SMYD2-A , N-lysine methyltransferase SMYD2-A , SET and MYND domain-containing protein 2A , SET and MYND domain containing 2 , histone methyltransferase SMYD2-A , Histone methyltransferase SMYD2 , SET and MYND domain-containing 2 , SET and MYND domain-containing protein 2-like , N-lysine methyltransferase SMYD2-B , SET and MYND domain-containing protein 2B , histone methyltransferase SMYD2-B

GENE ID SPECIES
56950 Homo sapiens
226830 Mus musculus
289372 Rattus norvegicus
379943 Xenopus laevis
421361 Gallus gallus
457729 Pan troglodytes
480026 Canis lupus familiaris
541423 Danio rerio
615229 Bos taurus
709375 Macaca mulatta
100023305 Monodelphis domestica
100052774 Equus caballus
100230503 Taeniopygia guttata
100294706 Sus scrofa
100344249 Oryctolagus cuniculus
100404005 Callithrix jacchus
100439768 Pongo abelii
100603309 Nomascus leucogenys
568616 Danio rerio
100720451 Cavia porcellus
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