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SH2D3C encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration.
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The structure of the NSP3-p130Cas (show BCAR1 Antibodies) complex reveals that this closed conformation is instrumental for interaction of NSP (show RTN1 Antibodies) proteins with a focal adhesion-targeting domain present in Cas (show CSE1L Antibodies) proteins.
This protein positively regulates T cell receptor-mediated interleukin-2 (show IL2 Antibodies) production by Jurkat cells.
SH2D3C (SHEP1) is less highly expressed than BCAR3 (show BCAR3 Antibodies) and NSP1 (show SH2D3A Antibodies) in breast cancer cells, and the expression patterns suggest differential roles for the three genes during breast cancer progression.
NSP3 overexpression did not induce anti-estrogen resistance in breast tumor cell lines.
Shep1 plays a critical role in the in vivo regulation of Src (show SRC Antibodies) activity and Cas (show CTNND1 Antibodies) downstream signaling through Crk protein (show CRKL Antibodies).
SHEP1 and CasL (show NEDD9 Antibodies) are constitutively associated in B cells.
Shep1 plays an important role in the early ingrowth of peripheral olfactory sensory axons into the forebrain.
Sh2d3c is required for proper localization of cells, particularly marginal zone B cells in vivo; thymi of Sh2d3c-deficient mice show no maturational abnormalities.
glutamic acid mutation of tyrosine 635 makes SHEP1 unable to promote Cas (show CTNND1 Antibodies)-Crk (show CRK Antibodies) association, membrane ruffling, and cell migration toward epidermal growth factor (EGF (show EGF Antibodies)), implying that these activities of SHEP1 depend upon a physical interaction with Cas (show CTNND1 Antibodies)
This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene.
SH2 domain containing 3C
, SH2 domain-containing protein 3C-like
, SH2 domain-containing Eph receptor-binding protein 1
, SH2 domain-containing protein 3C
, novel SH2-containing protein 3
, Cas/HEF1-associated signal transducer