anti-SH2B Adaptor Protein 3 (SH2B3) Antibodies

SH2B3 encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. Additionally we are shipping SH2B3 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SH2B3 10019 Q9UQQ2
SH2B3 16923 O09039
SH2B3 58838 P50745
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Top anti-SH2B3 Antibodies at antibodies-online.com

Showing 10 out of 70 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of LNK expression in HEK293T (A), Raw264.7 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Goat Un-conjugated ELISA, WB ABIN185272 (0.3µg/ml) staining of MOLT4 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Mouse Un-conjugated FACS, IF, WB 100 μL Log in to see 7 to 9 Days
$507.83
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: LNK Antibody [NBP1-87867] - Staining of human cell line U-2 OS shows positivity in nuclei. Immunohistochemistry-Paraffin: LNK Antibody [NBP1-87867] - Staining of human lymph node shows strong nuclear membrane positivity in reaction center cells and lymphoid cells outside reaction center. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Goat Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
$610.50
Details
Human Mouse Un-conjugated FACS, WB HEK293T cells transfected with either RC218359 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-SH2B3 antibody (ABIN2454461), and then analyzed by flow cytometry. HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SH2B3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-SH2B3. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IF, IHC, WB HEK293T cells transfected with either RC218359 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-SH2B3 antibody (ABIN2454471), and then analyzed by flow cytometry. Anti-SH2B3 mouse monoclonal antibody (ABIN2454471) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SH2B3 (RC218359). 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Mouse Lymph node lysate; Primary Ab: 5µg/ml Rabbit Anti-Human Lnk Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) 100 μg Log in to see 13 to 16 Days
$350.00
Details
Human Goat Un-conjugated WB 0.1 mg Log in to see 3 to 4 Days
$560.35
Details
Human Goat Biotin ELISA, WB   100 μL Log in to see 16 Days
$760.57
Details

SH2B3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SH2B3 Antibodies

  1. Human Polyclonal SH2B3 Primary Antibody for WB - ABIN2475350 : Yu, Xu: [Highlights of thromboxane synthetase inhibitor research]. in Sheng li ke xue jin zhan [Progress in physiology] 1991 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal SH2B3 Primary Antibody for ELISA, WB - ABIN151695 : Gery, Cao, Gueller, Xing, Tefferi, Koeffler: Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F. in Journal of leukocyte biology 2009 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal SH2B3 Primary Antibody for ICC, IF - ABIN4331277 : Flister, Endres, Rudemiller, Sarkis, Santarriaga, Roy, Lemke, Geurts, Moreno, Ran, Tsaih, De Pons, Carlson, Tan, Fahrenkrug, Lazarova, Lazar, North, LaViolette, Dwinell, Shull, Jacob: CXM: a new tool for mapping breast cancer risk in the tumor microenvironment. in Cancer research 2014 (PubMed)

More Antibodies against SH2B3 Interaction Partners

Human SH2B Adaptor Protein 3 (SH2B3) interaction partners

  1. In conclusion, germ line LNK mutations rarely occur in familial myeloproliferative neoplasms (MPNs) and do not segregate with the disease phenotype. The findings suggest that mutations in LNK, either germ line or acquired, may cooperate with acquired driver mutations in JAK2 (show JAK2 Antibodies), CALR (show CALR Antibodies), or MPL (show MPL Antibodies) to determine disease phenotype in MPNs.

  2. indicate that IL7RhighSH2B3low expression distinguishes a novel subset of high-risk B-acute lymphoblastic leukemia associated with Ikaros (show IKZF1 Antibodies) dysfunction

  3. Elevated expression of Lnk in polycystic ovary syndrome suggests that Lnk probably plays a role in the development of insulin (show INS Antibodies) resistance.

  4. Hypercholesterolemia acts in platelets and hematopoietic progenitors to exacerbate thrombosis and atherosclerosis associated with SH2B3 deficiency.

  5. The polymorphisms in LNK gene correlated to the clinical type of myeloproliferative neoplasms regardless of the JAK2 (show JAK2 Antibodies) polymorphism.

  6. SH2B3 mutations occur infrequently, and exon 8 in SH2B3 may be the most frequent mutational area in BCR-ABL (show ABL1 Antibodies) negative myeloproliferative neoplasms patients in Korea.

  7. LNK/SH2B3 is a key driver gene for human hypertension, and alteration of LNK in animal models has a profound effect on inflammation and hypertension. Thus, LNK is a potential therapeutic target for this disease and its devastating consequences.

  8. Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1 (show TSHZ1 Antibodies).

  9. results suggest that LNK suppresses IL-7R/JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies) signaling to restrict pro-/pre-B progenitor expansion and leukemia development, providing a pathogenic mechanism and a potential therapeutic approach for B-ALLs with LNK mutations.

  10. the minor allele A of rs3184504 (A vs G, OR = 1.18, 95%CI = 1.12-1.24, P < 0.001) in SH2B3 significantly increased celiac disease susceptibility (Meta-Analysis)

Mouse (Murine) SH2B Adaptor Protein 3 (SH2B3) interaction partners

  1. Lnk Deficiency Leads to TPO (show THPO Antibodies)-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype

  2. Specific targeting of Lnk may be a promising EPC (show TCF21 Antibodies)-based therapeutic strategy for dermal wound healing.

  3. The LNK plays a regulatory role in the palmitate-related preadipocyte apoptosis and might be involved in adipose tissue dysfunction.

  4. We found that a significant number of genes predicted to be regulated by SH2B3 in gene networks are perturbed in Sh2b3(-/-) mice, which demonstrate an exaggerated pressor response to angiotensin II infusion.

  5. results suggest that LNK suppresses IL-7R/JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies) signaling to restrict pro-/pre-B progenitor expansion and leukemia development, providing a pathogenic mechanism and a potential therapeutic approach for B-ALLs with LNK mutations.

  6. SH2B3 functions as a novel and effective modulator of cardiac remodeling and failure.

  7. Loss of LNK in hematopoietic cells is primarily responsible for the observed renal and vascular inflammation and predisposition to hypertension.

  8. Lnk/Sh2b3 plays a regulatory role in the expansion of Dendritic cells and might influence inflammatory immune responses in peripheral lymphoid tissues.

  9. results reveal a link between Lnk and immune cell-mediated intestinal tissue destruction.

  10. IL-11 (show IL11 Antibodies) therefore drives a pathway that enhances HSPC (show PSMA7 Antibodies) radioresistance and radiation-induced B-cell malignancies, but is normally attenuated by the inhibitory adaptor Lnk.

SH2B3 Antigen Profile

Protein Summary

This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.

Gene names and symbols associated with SH2B3

  • SH2B adaptor protein 3 (SH2B3) antibody
  • SH2B adaptor protein 3 (Sh2b3) antibody
  • AI429800 antibody
  • IDDM20 antibody
  • Lnk antibody

Protein level used designations for SH2B3

lymphocyte adaptor protein , SH2B adapter protein 3 , lymphocyte-specific adapter protein Lnk , signal transduction protein Lnk , linker of T-cell receptor pathways , lymphocyte adapter protein

GENE ID SPECIES
452245 Pan troglodytes
710839 Macaca mulatta
10019 Homo sapiens
16923 Mus musculus
58838 Rattus norvegicus
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