anti-SLAM Family Member 6 (SLAMF6) Antibodies

The protein encoded by SLAMF6 is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. Additionally we are shipping SLAMF6 Proteins (24) and SLAMF6 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SLAMF6 114836 Q96DU3
SLAMF6 30925 Q9ET39
SLAMF6 498287  
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Top anti-SLAMF6 Antibodies at antibodies-online.com

Showing 10 out of 110 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SLAMF6 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Human Placenta 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated CyTOF, FACS Detection of NTB-A/SLAMF6 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human NTB-A/SLAMF6 Monoclonal Antibody. 100 μg Log in to see 8 to 9 Days
$311.88
Details
Human Mouse Fluorescein FACS Detection of NTB-A/SLAMF6 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human NTB-A/SLAMF6 Fluorescein-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$276.85
Details
Human Mouse PE FACS Detection of NTB-A/SLAMF6 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human NTB-A/SLAMF6 PE-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$342.39
Details
Human Mouse APC FACS Detection of NTB-A/SLAMF6 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human NTB-A/SLAMF6 APC-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$385.33
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of  CD352 / SLAMF6 Antibody (C-term) Cat.-No AP53926PU-N in T47D cell line lysates (35ug/lane). This demonstrates the SLAMF6 antibody detected the SLAMF6 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Mouse Un-conjugated FACS 100 μg Log in to see 11 to 14 Days
$346.50
Details
Human Mouse Un-conjugated FACS 500 μg Log in to see 10 to 12 Days
$462.10
Details

Top referenced anti-SLAMF6 Antibodies

  1. Human Monoclonal SLAMF6 Primary Antibody for CyTOF, FACS - ABIN4900064 : Banerjee, Feuer, Barker et al.: Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous ... in Journal of virology 2007 (PubMed)
    Show all 6 Pubmed References

  2. Human Monoclonal SLAMF6 Primary Antibody for FACS - ABIN4897126 : Sullivan, Jeha, Kang, Cheng, Rooney, Holladay, Bari, Schell, Tuggle, Pui, Leung: NK cell genotype and phenotype at diagnosis of acute lymphoblastic leukemia correlate with postinduction residual disease. in Clinical cancer research : an official journal of the American Association for Cancer Research 2014 (PubMed)

  3. Human Monoclonal SLAMF6 Primary Antibody for FACS - ABIN4897122 : Kmiec, Iyer, Stürzel, Sauter, Hahn, Kirchhoff: Vpu-Mediated Counteraction of Tetherin Is a Major Determinant of HIV-1 Interferon Resistance. in mBio 2016 (PubMed)

  4. Human Monoclonal SLAMF6 Primary Antibody for FACS - ABIN4897128 : Brunetta, Fogli, Varchetta, Bozzo, Hudspeth, Marcenaro, Moretta, Mavilio: The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia. in Blood 2009 (PubMed)

  5. Human Polyclonal SLAMF6 Primary Antibody for WB - ABIN530287 : Proust, Bertoglio, Gesbert: The adaptor protein SAP directly associates with CD3? chain and regulates T cell receptor signaling. in PLoS ONE 2012 (PubMed)

More Antibodies against SLAMF6 Interaction Partners

Human SLAM Family Member 6 (SLAMF6) interaction partners

  1. these results showed that the NTB-A/SAP pathway regulates T-cell activation and restimulation-induced cell death during human tuberculosis

  2. in addition to its established role in Invariant NKT(iNKT) cell ontogeny, Ly108 regulates iNKT cell function in mice and humans

  3. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  4. our data reveal how SAP nucleates a previously unknown signaling complex involving NTB-A and LCK to potentiate restimulation-induced cell death of activated human T cells.

  5. Together, these results suggest that the reduction of NTB-A from the cell surface is associated with the Vpu-mediated effect on the glycosylation pattern of newly synthesized NTB-A molecules.

  6. Data indicate that the dominance of the SLAMF3/SLAMF6 pathway in inducing IL-17A production can be attributed to an increased nuclear abundance and recruitment of RORgammat to the IL17A promoter.

  7. SLAMF3 and SLAMF6 T cell surface expression and IL-17 levels significantly correlate with disease activity in systemic lupus erythematosus patients

  8. Although the expression of SLAMF6 on the surface of T cells from patients with systemic lupus erythematosus (SLE) T cells is comparable to that on the normal T cells, engagement of SLAMF6 results in severely reduced Th1 and IL-2 cytokine production

  9. Vpu downmodulation of NTB-A protects the infected cell from lysis by NK cells.

  10. regulation of interferon-gamma secretion, and not interleukin-4 in vitro, as well as inhibition of Th1 cell-induced isotype switching and attenuation of experimental allergic encephalomyelitis identifies NTB-A as a regulator of T cell response

  11. NTB-A is an interlymphocyte signaling molecule, which serves to orchestrate the activities of immune cells.

  12. blocking the engagement of 2B4, NTB-A and CRACC has no effect on the proliferation or development of the cytotoxic potential of NK cells but triggering by their physiological ligands on MHC class I-negative target cells induces potent NK cell cytotoxicity

  13. NTB-A-mediated IFN-gamma production was greatly reduced in the absence of SLAM-associated protein (SAP), demonstrating that cytokine production and cytotoxicity are differentially dependent on SAP and possibly EAT-2

  14. The 3.0 A crystal structure of the complete NTB-A ectodomain revealed a rod-like monomer that self-associates to form a highly kinked dimer spanning an end-to-end distance of approximately 100 A.

  15. HTLV-1-infected CD4+ T cells did not express ligands for NK cell activating receptors, NCR and NKG2D, although they did express ligands for NK cell coactivating receptors, NTB-A and 2B4.

  16. 2B4, NTB-A and CRACC have roles in the regulation of Natural Killer cell function [review]

Mouse (Murine) SLAM Family Member 6 (SLAMF6) interaction partners

  1. naive T cells regulate B cell survival in a SLAMF6-dependent manner

  2. in addition to its established role in Invariant NKT(iNKT) cell ontogeny, Ly108 regulates iNKT cell function in mice and humans

  3. CRISPR-Mediated Slamf1Delta/Delta Slamf5Delta/Delta Slamf6Delta/Delta Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell Defects.

  4. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  5. study establishes a central role for germinal center B cell-specific CD84 and Ly108 expression in maintaining B cell tolerance in germinal centers and in preventing autoimmunity

  6. When Ly108 is engaged in trans during cell-cell interactions, Ly108-CD3zeta interactions are promoted in a manner that uniquely depends on Ly108 TM domain, leading to more efficient CD3zeta dephosphorylation.

  7. Ly108 expression distinguishes subsets of invariant NKT cells that help autoantibody production and secrete IL-21 from those that secrete IL-17 in lupus prone NZB/W mice.

  8. Data indicate that Slamf6-H1 suppresses the spontaneous expansion of a unique osteopontin OPN+ T follicular helper (TFH) cells.

  9. Ly108 plays a role in the induction of PLZF in developing thymocytes.

  10. In the absence of SAP, signaling through the SLAM family members Ly108 and 2B4 resulted in increased recruitment of the SHP-1 phosphatase, associated with altered SHP-1 localization and decreased activation of Src kinases at the synapse.

  11. Ly 108 deletion in T4 cells reversed the Sh2d1a(-/-) phenotype, eliminating the SAP requirement for germinal centers and restoring NKT-cell differentiation. This required immunotyrosine switch motifs (ITSMs) & SHP-1 recruitment.

  12. 3 isoforms of Ly108 mRNA & protein are differentially expressed in the thymi of C57BL/6 & 129S6 mice expressing the lupus-resistant & lupus-prone haplotypes of Ly108, respectively. Ly108-H1 is a decoy isoform.

  13. an immune response-suppressing isoform of Ly108 can regulate the pathogenesis of lupus.

  14. Following targeted disruption of the LY108 gene, CD4+ T cell and innate responses are defective; a surprising role for Ly108 is revealed in the control of responses to bacteria by neutrophils, while macrophage functions are intact.

  15. normal Ly108.2 allele, but not lupus-associated Ly108.1 allele, sensitized immature B cells to deletion & RAG reexpression; as a potential regulator of tolerance checkpoints, Ly108 may censor self-reactive B cells, safeguarding against autoimmunity

  16. control of NKT cell numbers attributed to the Nkt1 gene is mediated by differential expression of Slamf1 and an additional contribution by Slamf6.

  17. 2B4, NTB-A and CRACC have roles in the regulation of Natural Killer cell function [review]

  18. Ly108-triggered protein tyrosine phosphorylation was due to the capacity of SAP to recruit FynT

SLAMF6 Antigen Profile

Protein Summary

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with SLAMF6

  • SLAM family member 6 (SLAMF6) antibody
  • SLAM family member 6 (Slamf6) antibody
  • CD352 antibody
  • KAL1 antibody
  • KAL1b antibody
  • KALI antibody
  • KALIb antibody
  • Ly108 antibody
  • NTB-A antibody
  • NTBA antibody
  • RGD1561848 antibody
  • SF2000 antibody
  • SLAMF6 antibody

Protein level used designations for SLAMF6

SLAM family member 6 , activating NK receptor , NK-T-B-antigen , NTBA receptor , natural killer-, T- and B-cell antigen , lymphocyte antigen 108

GENE ID SPECIES
508183 Bos taurus
719728 Macaca mulatta
746886 Pan troglodytes
100156912 Sus scrofa
114836 Homo sapiens
30925 Mus musculus
498287 Rattus norvegicus
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