anti-SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2) Antibodies

This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. Additionally we are shipping SRGAP2 Kits (3) and SRGAP2 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SRGAP2 23380 O75044
SRGAP2 14270 Q91Z67
SRGAP2 360840 D4A208;
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Top anti-SRGAP2 Antibodies at antibodies-online.com

Showing 10 out of 35 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Goat Un-conjugated ELISA, IF   100 μg 6 to 7 Days
$429.84
Details
Hamster Goat Un-conjugated IF, ELISA 100 μg 11 to 14 Days
$610.50
Details
Cow Goat Un-conjugated EIA, IF   0.1 mg 4 to 8 Days
$462.00
Details
Human Goat Un-conjugated ELISA, IF, WB HEK293 overexpressing human SRGAP2 and probed with SRGAP2 polyclonal antibody  at 2.5 ug/mL in the right panel. Data kindly provided by Ms. Ya-Jing Mi and Dr.Wei-Lin Jin, Institute of Neurosciences, Shanghai Jiao Tong University. SRGAP2 polyclonal antibody  (0.1 ug/mL) staining of rat cortical neuron lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Data kindly provided by Ms. Ya-Jing Mi and Dr.Wei-Lin Jin, Institute of Neurosciences, Shanghai Jiao Tong University. 100 μg 11 to 12 Days
$374.67
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining of human duodenum with SRGAP2 polyclonal antibody  shows strong membranous positivity in glandular cells at 1:20-1:50 dilution. 100 μL 11 to 12 Days
$577.33
Details
Human Goat Un-conjugated ELISA, WB 200 μL 7 to 11 Days
$397.98
Details
Human Rabbit Un-conjugated WB   100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated ELISA, IHC, WB   100 μg 13 to 16 Days
$407.69
Details
Human Rabbit Un-conjugated WB   100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB   100 μL 2 to 3 Days
$289.00
Details

Top referenced anti-SRGAP2 Antibodies

  1. Human Polyclonal SRGAP2 Primary Antibody for ELISA, ICC - ABIN4355968 : Jin, Smith, Stark, Wells, Fawcett, Kulkarni, Metalnikov, ODonnell, Taylor, Taylor, Zougman, Woodgett, Langeberg, Scott, Pawson: Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. in Current biology : CB 2004 (PubMed)

More Antibodies against SRGAP2 Interaction Partners

Human SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2) interaction partners

  1. These results indicated that the SRGAP2 SNPs and their haplotypes were associated with serum lipid levels. Their haplotypes can explain much more serum lipid variation than any single SNP alone, especially for serum TC, HDL-C and ApoA1 levels.

  2. Results show that in high-grade, stage II osteosarcoma samples, expression of SRGAP2 was substantially reduced or absent in over half of the samples. Functional analysis provides further evidence that SRGAP2 may have a role as a suppressor of metastases in osteosarcoma.

  3. SRGAP2a protects podocytes in diabetic nephropathy by suppressing podocyte migration.

  4. The extended F-BAR (F-BARx) domain of SRGAP2 generates membrane protrusions when expressed in COS-7 cells, while most F-BARs induce the opposite effect: membrane invaginations. As a first step to understand this discrepancy, the F-BARx domain of SRGAP2 was isolated and crystallized after co-expression with the carboxy domains of the protein. Diffraction data were reprocessed with a high-resolution cutoff of 2.2 A.

  5. human-specific duplication of SRGAP2 might have contributed to the emergence of unique traits of human neurons while preserving the excitation/inhibition balance

  6. This study illustrated that the role of SRGAP2 protein and its human-specific paralogs in human brain development and evolution.

  7. interlocus gene conversions in SRGAP2

  8. SRGAP2 has been highly conserved over mammalian evolution, and human is the only lineage wherein gene duplications have occurred. Our analysis indicates that the duplications spread across 80 Mbp of chromosome 1 at a time corresponding to the transition from Australopithecus to Homo.

  9. Results uncover a new function for ancestral SRGAP2 in promoting dendritic spine maturation and indicate that expression of a human-specific paralog of SRGAP2 in mouse pyramidal neurons extends the phase of spine development and leads to an increased density of longer spines in vivo, a feature characterizing pyramidal neurons in the human neocortex

  10. after Rac-dependent activation of FMNL1, srGAP2 mediates a potent mechanism to limit the duration of Rac action and inhibit formin activity during rapid actin dynamics.

  11. srGAP2 arginine methylation plays important roles in cell spreading and cell migration through influencing membrane protrusion.

  12. FNBP2 gene was linked to IKBKE and NORE1 genes on human chromosome 1q32.1. FNBP2 mRNA was expressed in melanoma, germ cell tumors, chondrosarcoma and retinoblastoma.

Mouse (Murine) SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2) interaction partners

  1. Results show that the effects of Srgap2 expression modulation in the murine OS cell lines support the hypothesis that SRGAP2 may have a role as a suppressor of metastases in osteosarcoma.

  2. SRGAP2a protects podocytes in diabetic nephropathy by suppressing podocyte migration.

  3. The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells.

  4. Data show that srGAP2 is expressed in zones of neuronal differentiation in many different tissues of the central nervous system.

  5. Study reports that srGAP2 negatively regulates neuronal migration and induces neurite outgrowth and branching through the ability of its F-BAR domain to induce filopodia-like membrane protrusions resembling those induced by I-BAR domains.

Zebrafish SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2) interaction partners

  1. SRGAP2a protects podocytes in diabetic nephropathy by suppressing podocyte migration. Knockdown of SRGAP2a, a SRGAP2 ortholog in zebrafish, recapitulates podocyte foot process effacement.

SRGAP2 Antigen Profile

Protein Summary

This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogous loci on human chromosome 1, resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus.

Gene names and symbols associated with SRGAP2

  • SLIT-ROBO Rho GTPase activating protein 2 (SRGAP2) antibody
  • SLIT-ROBO Rho GTPase activating protein 2 (Srgap2) antibody
  • SLIT-ROBO Rho GTPase activating protein 2 (srgap2) antibody
  • 9930124L22Rik antibody
  • AI448945 antibody
  • ARHGAP34 antibody
  • FBP2 antibody
  • Fnbp2 antibody
  • RGD1566016 antibody
  • srGAP2 antibody
  • srgap2a antibody
  • srGAP3 antibody
  • wu:fb47h12 antibody
  • zgc:136814 antibody

Protein level used designations for SRGAP2

SLIT-ROBO Rho GTPase-activating protein 2 , formin binding protein 2 , formin-binding protein 2 , rho GTPase-activating protein 34 , FBP-27 , formin-binding protein 27 , LOW QUALITY PROTEIN: SLIT-ROBO Rho GTPase-activating protein 2 , SLIT-ROBO Rho GTPase activating protein 2a

GENE ID SPECIES
23380 Homo sapiens
14270 Mus musculus
360840 Rattus norvegicus
100716665 Cavia porcellus
556198 Danio rerio
478949 Canis lupus familiaris
519843 Bos taurus
100050923 Equus caballus
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