anti-SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6) Antibodies

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Additionally we are shipping SMC6 Proteins (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SMC6 79677 Q96SB8
SMC6 67241 Q924W5
SMC6 313961  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-SMC6 Antibodies at antibodies-online.com

Showing 10 out of 41 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SMC6 Antibody Titration: 1.0 ug/ml Positive Control: MCF7 Whole Cell SMC6 is supported by BioGPS gene expression data to be expressed in MCF7 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, WB Detection of SMC6 in TK6 (lymphoblastoid cells) whole cell lysate using ABIN151917. Western Blot: SMC6L1 Antibody [ABIN151917] - Whole cell lysate (50 ug) from 293T, HeLa, and Jurkat cells. 100 μL Log in to see 7 to 9 Days
$556.31
Details
Human Mouse Un-conjugated ELISA, IHC, WB SMC6L1 monoclonal antibody (M01), clone 2E6 Western Blot analysis of SMC6L1 expression in HeLa on formalin-fixed paraffin-embedded human placenta (antibody concentration 3 µg/mL). 100 μg Log in to see 8 to 11 Days
$461.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunohistochemistry-Paraffin: SMC6L1 Antibody [NBP2-33378] - liver Immunohistochemistry: SMC6L1 Antibody [NBP2-33378] - Immunohistochemical staining of human colon shows moderate cytoplasmic and nuclear positivity in glandular cells. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to SMC6L1 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml] SMC6L1 monoclonal antibody (M01), clone 2E6 Western Blot analysis of SMC6L1 expression in HeLa . 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Mouse Un-conjugated ELISA, IHC, IHC (p), WB 100 μg Log in to see 7 to 9 Days
$537.17
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: SMC6L1 Antibody [NBP2-20420] - Sample (30 ug of whole cell lysate) A: NT2D1 7. 5% SDS PAGE gel, diluted at 1:1000. Immunocytochemistry/Immunofluorescence: SMC6L1 Antibody [NBP2-20420] - Analysis of paraformaldehyde-fixed MCF-7, using antibody at 1:200 dilution. 0.1 mL Log in to see 8 to 11 Days
$514.63
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of SMC6L1 using anti-SMC6L1 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: human Hela whole cell lysates, Lane 2: human HepG2 whole cell lysates, Lane 3: human PANC-1 whole cell lysates, Lane 4: human SK-OV-3 whole cell lysates, Lane 5: human COLO-320 whole cell lysates, Lane 6: rat testis tissue lysates, Lane 7: mouse testis tissue lysates.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-SMC6L1 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for SMC6L1 at approximately 126KD. The expected band size for SMC6L1 is at 126KD. 100 μg Log in to see 4 to 6 Days
$280.00
Details
Cow Rabbit Un-conjugated WB   50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 2 to 3 Days
$289.00
Details

SMC6 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
,
,
, , , , , , , , , , , , ,
Mouse (Murine) ,


, , , , , , , , , , , , ,
Rat (Rattus) ,


, , , , , , , , , , , , ,

Top referenced anti-SMC6 Antibodies

  1. Human Monoclonal SMC6 Primary Antibody for IHC (p), ELISA - ABIN566368 : Gallego-Paez, Tanaka, Bando, Takahashi, Nozaki, Nakato, Shirahige, Hirota: Smc5/6-mediated regulation of replication progression contributes to chromosome assembly during mitosis in human cells. in Molecular biology of the cell 2014 (PubMed)

More Antibodies against SMC6 Interaction Partners

Human SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6) interaction partners

  1. SMC5 (show SMC5 Antibodies)/6 knockdown rescued HBx-deficient hepatitis b virus replication in human hepatocytes.

  2. High SMC6 protein is associated with hepatitis B.

  3. Brazilian Amerindian ancestry compared to Asian, European, and African Genomes.SNPs within or proximal to CIITA (show CIITA Antibodies) (rs6498115), SMC6 (rs1834619), and KLHL29 (rs2288697) were most differentiated in the Amerindian-specific branch. SNPs in ADAMTS9 (show ADAMTS9 Antibodies) (rs7631391), DOCK2 (show DOCK2 Antibodies) (rs77594147), SLC28A1 (show SLC28A1 Antibodies) (rs28649017), ARHGAP5 (show ARHGAP5 Antibodies) (rs7151991), and CIITA (show CIITA Antibodies) (rs45601437) in the Asian comparison.

  4. The SMC5 (show SMC5 Antibodies)/6 complex physically interacts with the DNA topoisomerase II alpha (TOP2A (show TOP2A Antibodies)).

  5. results uncover a novel role for the Smc5 (show SMC5 Antibodies)/6 complex as a restriction factor selectively blocking extrachromosomal DNA transcription; by destroying this complex, HBx relieves the inhibition to allow productive hepatitis B virus gene expression

  6. Structural maintenance of chromosomes (SMC (show DYM Antibodies)) complexes, which in eukaryotic cells include cohesin, condensin and the Smc5 (show SMC5 Antibodies)/6 complex, are central regulators of chromosome dynamics

  7. Depletion of Smc5 (show SMC5 Antibodies) and Smc6 resulted in aberrant mitotic chromosome phenotypes that were accompanied by the abnormal distribution of topoisomerase IIalpha (topo IIalpha) and condensins and by chromosome segregation errors

  8. Studies indicate that Nse1 (show FAM84A Antibodies) may function as a ubiquitin ligase, and is targeted to chromatin through its interaction with the Smc5 (show SMC5 Antibodies)/6 complex.

  9. the human SMC5 (show SMC5 Antibodies)/6 complex and the SUMO ligase activity of hMMS21 (show NSMCE2 Antibodies) are required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair in human cells

  10. SMC5/6 complex is recruited to nuclease-induced double-strand breaks (DSBs) and is required for the recruitment of cohesin to DSBs.

Mouse (Murine) SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6) interaction partners

  1. age-dependent depletion of the SMC5 (show SMC5 Antibodies)/6 complex in oocytes could contribute to increased incidence of oocyte aneuploidy and spontaneous abortion in aging females.

  2. Smc6 has a role in the prevention of aberrant recombination events between pericentromeric regions during the first meiotic prophase.

  3. Mice deleted for the SMC6 gene are inviable, and mice mutated at Ser (show SIGLEC1 Antibodies)-994 in the SMC6 ATPase (show DNAH8 Antibodies) domain have a mild phenotype.

SMC6 Antigen Profile

Protein Summary

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity).

Gene names and symbols associated with SMC6

  • structural maintenance of chromosomes 6 (SMC6) antibody
  • structural maintenance of chromosomes 6 (smc6) antibody
  • structural maintenance of chromosomes 6 (Smc6) antibody
  • 2810489L22Rik antibody
  • 3830418C19Rik antibody
  • AA990493 antibody
  • AU018782 antibody
  • AW742439 antibody
  • hSMC6 antibody
  • mKIAA4103 antibody
  • SMC-6 antibody
  • Smc6l1 antibody

Protein level used designations for SMC6

SMC6 structural maintenance of chromosomes 6-like 1 , SMC protein 6 , structural maintenance of chromosomes protein 6 , mSMC6

GENE ID SPECIES
421950 Gallus gallus
446077 Takifugu rubripes
79677 Homo sapiens
67241 Mus musculus
475675 Canis lupus familiaris
100517523 Sus scrofa
510381 Bos taurus
313961 Rattus norvegicus
Selected quality suppliers for anti-SMC6 (SMC6) Antibodies
Did you look for something else?