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expressed in 12 day embryo and in a chemically induced pancreatic B-cell tumor; not expressed in normal differentiated cells. Additionally we are shipping SUB1 Kits (24) and and many more products for this protein.
Showing 10 out of 70 products:
Human Polyclonal SUB1 Primary Antibody for WB - ABIN1881856
Das, Gadad, Kundu: Human positive coactivator 4 controls heterochromatinization and silencing of neural gene expression by interacting with REST/NRSF and CoREST. in Journal of molecular biology 2010
Show all 5 Pubmed References
Human Polyclonal SUB1 Primary Antibody for ICC, IF - ABIN4356694
Chakravarthi, Goswami, Pathi, Robinson, Cieślik, Chandrashekar, Agarwal, Siddiqui, Daignault, Carskadon, Jing, Chinnaiyan, Kunju, Palanisamy, Varambally: MicroRNA-101 regulated transcriptional modulator SUB1 plays a role in prostate cancer. in Oncogene 2016
Show all 2 Pubmed References
Human Polyclonal SUB1 Primary Antibody for ICC, IF - ABIN252962
Lin, Chang, Hsu, Chi, Chien, Liang, Tsai, Lin, Yu: Low-molecular-mass secretome profiling identifies C-C motif chemokine 5 as a potential plasma biomarker and therapeutic target for nasopharyngeal carcinoma. in Journal of proteomics 2013
Evolutionarily conserved role for Sub1 and PC4 (show IFRD1 Antibodies) in the maintenance of yeast and human genome stability has been summarized. (Review)
Yeast Sub1 and human PC4 (show IFRD1 Antibodies) are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA.
Results show elevated expression of SUB1 in aggressive prostate cancer. Knockdown of SUB1 in prostate cancer cells resulted in reduced cell proliferation, invasion and migration.
these data provide a novel mode of PC4 (show IFRD1 Antibodies) binding to a DNA secondary structure that remains within the framework of the model for binding to ssDNA. Additionally, consideration of the PC4 (show IFRD1 Antibodies)-G4DNA interaction could provide insight into the biological functions of PC4 (show IFRD1 Antibodies), which remain incompletely understood.
PC4 (show IFRD1 Antibodies) associates with Aurora A (show AURKA Antibodies) and Aurora B (show AURKB Antibodies) and undergoes phosphorylation, following which PC4 (show IFRD1 Antibodies) activates both Aurora A (show AURKA Antibodies) and B to sustain optimal kinase activity to maintain the phosphorylation gradient for the proper functioning of the mitotic machinery.
PC4 has similar functions to RPA in binding ssDNA to promote genome stability, especially at sites of replication-transcription collisions.
SMYD3 (show SMYD3 Antibodies) interacts with the human positive coactivator 4 (PC4 (show IFRD1 Antibodies)) and that such interaction potentiates a group of genes whose expression is linked to cell proliferation and invasion.
Sub1, and its human homolog PC4 (show IFRD1 Antibodies), bind preferentially to G-quadruplexes
expression of PC4 (show IFRD1 Antibodies) in astrocytoma was upregulated as assessed by western blot and immunohistochemical staining. Moreover, elevated PC4 (show IFRD1 Antibodies) expression was strongly correlated with the progression of astrocytoma and overall survival.
PC4 (show IFRD1 Antibodies) protects esophageal squamous cell carcinoma cells from IR-induced death by enhancing the nonhomologous end joining-promoting activity of XLF (show NHEJ1 Antibodies).
These observations indicate that non-histone chromatin-associated proteins like PC4 (show IFRD1 Antibodies) play a significant role in neuronal plasticity.
Results suggest that positive cofactor 4 (Pc4) has an important role in inducing spontaneous somatic cell reprogramming via up-regulation of key pluripotency genes.
Redox-mediated upregulation of hepatocyte iNOS (show NOS2 Antibodies) transcription requires an HNF-4alpha (show HNF4A Antibodies)-PC4 (show IFRD1 Antibodies) transcriptional complex
Report recruitment of RNA polymerase II (show 0 Antibodies) cofactor PC4 (show IFRD1 Antibodies) to DNA damage sites.
expressed in 12 day embryo and in a chemically induced pancreatic B-cell tumor; not expressed in normal differentiated cells
activated RNA polymerase II transcription cofactor 4
, activated RNA polymerase II transcriptional coactivator p15
, positive cofactor 4
, RNA polymerase II transcriptional coactivator
, single-stranded DNA-binding protein p9
, pR-ET2 encoded oncodevelopmental protein