anti-SUB1 Homolog (S. Cerevisiae) (SUB1) Antibodies

expressed in 12 day embryo and in a chemically induced pancreatic B-cell tumor; not expressed in normal differentiated cells. Additionally we are shipping SUB1 Kits (24) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SUB1 10923 P53999
SUB1 20024 P11031
SUB1 192269 Q63396
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Top anti-SUB1 Antibodies at antibodies-online.com

Showing 10 out of 70 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB PC4 was detected in paraffin-embedded sections of human mammary cancer tissues using rabbit anti- PC4 Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 µg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). PC4 was detected in paraffin-embedded sections of mouse liver tissues using rabbit anti- PC4 Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 µg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). 100 μg Log in to see 4 to 6 Days
€247.79
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-PC4 Antibody Titration:  2.5ug/ml  Positive Control:  Raji cell lysate There is BioGPS gene expression data showing that SUB1 is expressed in Raji Human Lung 100 μL Log in to see 2 to 3 Days
€202.65
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-PC4 Antibody Titration:  0.5-1.0ug/ml  Positive Control:  HepG2 cell lysate There is BioGPS gene expression data showing that SUB1 is expressed in HepG2 Human Liver 100 μL Log in to see 2 to 3 Days
€220.35
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot and Immunoprecipitation: PC4 Antibody [ABIN252962] - Detection of Human PC4 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-PC4 antibody ABIN252962 used for WB at 0.04 mcg/ml (A) and 0.1 mcg/ml (B). PC4 was immunoprecipitated by rabbit anti-PC4 antibody ABIN252961, which recognizes an upstream epitope. Immunohistochemistry-Paraffin: SUB1 Antibody [ABIN2529625] - FFPE section of human prostate carcinoma. Affinity purified rabbit anti-PC4 used at a dilution of 1:250. Detection: DAB staining using Immunohistochemistry Accessory Kit 0.1 mL Log in to see 7 to 9 Days
€495.00
Details
Human Rabbit Un-conjugated IF/ICC, IHC, IP, WB Western blot analysis of extracts of various cell lines, using SUB1 antibody (ABIN5974252) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded human stomach using SUB1 antibody (ABIN5974252) at dilution of 1/100 (40x lens). 100 μL Log in to see 11 to 16 Days
€370.79
Details
Cow Rabbit Un-conjugated IHC, IHC (p), WB 100 μg Log in to see 11 to 14 Days
€436.43
Details
Human Rabbit Un-conjugated WB SUB1 Antibody (Center) (ABIN1881856) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the SUB1 antibody detected the SUB1 protein (arrow). 400 μL Log in to see 10 to 11 Days
€340.71
Details
Human Rabbit Un-conjugated IF, IHC, IP, WB Western blot analysis of extracts of various cell lines, using SUB1 antibody. Immunohistochemistry of paraffin-embedded human stomach using SUB1 antibody. 200 μL Log in to see 12 to 14 Days
€388.41
Details
Chicken Rabbit Un-conjugated IHC, IHC (p), WB 100 μg Log in to see 11 to 14 Days
€436.43
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human breast with SUB1 polyclonal antibody  shows strong nuclear positivity in glandular cells. Western blot analysis of lane 1: RT-4, lane 2: U-251 MG, lane 3: A-431, lane 4: Liver and lane 5: Tonsil using SUB1 polyclonal antibody . 100 μL Log in to see 11 to 12 Days
€400.00
Details

Top referenced anti-SUB1 Antibodies

  1. Human Polyclonal SUB1 Primary Antibody for WB - ABIN1881856 : Das, Gadad, Kundu: Human positive coactivator 4 controls heterochromatinization and silencing of neural gene expression by interacting with REST/NRSF and CoREST. in Journal of molecular biology 2010 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal SUB1 Primary Antibody for ICC, IF - ABIN4356694 : Chakravarthi, Goswami, Pathi, Robinson, Cieślik, Chandrashekar, Agarwal, Siddiqui, Daignault, Carskadon, Jing, Chinnaiyan, Kunju, Palanisamy, Varambally: MicroRNA-101 regulated transcriptional modulator SUB1 plays a role in prostate cancer. in Oncogene 2016 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal SUB1 Primary Antibody for ICC, IF - ABIN252962 : Lin, Chang, Hsu, Chi, Chien, Liang, Tsai, Lin, Yu: Low-molecular-mass secretome profiling identifies C-C motif chemokine 5 as a potential plasma biomarker and therapeutic target for nasopharyngeal carcinoma. in Journal of proteomics 2013 (PubMed)

More Antibodies against SUB1 Interaction Partners

Human SUB1 Homolog (S. Cerevisiae) (SUB1) interaction partners

  1. Study shows that PC4 might repress RNA pol II recruitment and transcription of replication-dependent histone genes in order to maintain the balance between histone gene expression and DNA synthesis. Moreover, PC4 might promote the interaction of cleavage and polyadenylation complex with histone pre-mRNAs, that might impede with the recruitment of histone cleavage complex.

  2. REVIEW: many evidences showed that Sub1 influences processes downstream during mRNA biogenesis, such as elongation, termination, and RNAPII phosphorylation. The recent discovery that Sub1 directly interacts with the RNAPII stalk adds new insights into how it achieves all these tasks.

  3. Evolutionarily conserved role for Sub1 and PC4 in the maintenance of yeast and human genome stability has been summarized. (Review)

  4. Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA.

  5. Results show elevated expression of SUB1 in aggressive prostate cancer. Knockdown of SUB1 in prostate cancer cells resulted in reduced cell proliferation, invasion and migration.

  6. these data provide a novel mode of PC4 binding to a DNA secondary structure that remains within the framework of the model for binding to ssDNA. Additionally, consideration of the PC4-G4DNA interaction could provide insight into the biological functions of PC4, which remain incompletely understood.

  7. PC4 associates with Aurora A and Aurora B and undergoes phosphorylation, following which PC4 activates both Aurora A and B to sustain optimal kinase activity to maintain the phosphorylation gradient for the proper functioning of the mitotic machinery.

  8. PC4 has similar functions to RPA in binding ssDNA to promote genome stability, especially at sites of replication-transcription collisions.

  9. SMYD3 interacts with the human positive coactivator 4 (PC4) and that such interaction potentiates a group of genes whose expression is linked to cell proliferation and invasion.

  10. Sub1, and its human homolog PC4, bind preferentially to G-quadruplexes

  11. expression of PC4 in astrocytoma was upregulated as assessed by western blot and immunohistochemical staining. Moreover, elevated PC4 expression was strongly correlated with the progression of astrocytoma and overall survival.

  12. PC4 protects esophageal squamous cell carcinoma cells from IR-induced death by enhancing the nonhomologous end joining-promoting activity of XLF.

  13. p38 MAP kinase mediated HNF4 Ser158 phosphorylation (P-HNF4-S158), binding of PC4 to P-HNF4-S158 and characterize the functional domain of PC4 required for P-HNF4-S158 binding.

  14. PC4 activates double-strand break (DSB) repair activity through stimulation of DSB rejoining in vivo

  15. acetylation of lysine 382/381 of p53 may play an important role in modulating p53-PC4 interaction and as a consequence PC4 mediated activation of p53 target genes.

  16. findings demonstrated a critical aspect of LHR modulation whereby PC4 acts as a coactivator of Sp1 to contribute to the human of LHR transcription

  17. Sub1/PC4 a chromatin associated protein with multiple functions in transcription.

  18. analysis of the interaction between the transactivation domain of p53 and PC4

  19. PC4 interacts with the DNA binding and C-terminal domains of p53 through its DNA binding domain, which is essential for the stimulation of p53 DNA binding.

  20. PC4 interacts with heterochromatin protein 1alpha, REST/NRSF (RE1-silencing transcription factor/neuron-restrictive silencer factor) and CoREST to establish the repressed state of neural genes in nonneuronal cells.

Mouse (Murine) SUB1 Homolog (S. Cerevisiae) (SUB1) interaction partners

  1. These observations indicate that non-histone chromatin-associated proteins like PC4 play a significant role in neuronal plasticity.

  2. Results suggest that positive cofactor 4 (Pc4) has an important role in inducing spontaneous somatic cell reprogramming via up-regulation of key pluripotency genes.

  3. Redox-mediated upregulation of hepatocyte iNOS transcription requires an HNF-4alpha-PC4 transcriptional complex

  4. Report recruitment of RNA polymerase II cofactor PC4 to DNA damage sites.

SUB1 Antigen Profile

Protein Summary

expressed in 12 day embryo and in a chemically induced pancreatic B-cell tumor; not expressed in normal differentiated cells

Gene names and symbols associated with SUB1

  • SUB1 homolog, transcriptional regulator (SUB1) antibody
  • SUB1 homolog (S. cerevisiae) (Sub1) antibody
  • SUB1 homolog, transcriptional regulator (Sub1) antibody
  • AI842364 antibody
  • P9 antibody
  • p14 antibody
  • P15 antibody
  • Pc4 antibody
  • Rpo2tc1 antibody

Protein level used designations for SUB1

activated RNA polymerase II transcription cofactor 4 , activated RNA polymerase II transcriptional coactivator p15 , positive cofactor 4 , RNA polymerase II transcriptional coactivator , p14 , single-stranded DNA-binding protein p9 , PC4 , pR-ET2 encoded oncodevelopmental protein

GENE ID SPECIES
10923 Homo sapiens
20024 Mus musculus
192269 Rattus norvegicus
427425 Gallus gallus
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