anti-SUMO/sentrin Specific Peptidase Family Member 8 (SENP8) Antibodies

SENP8 encodes a cysteine protease that is a member of the sentrin-specific protease family. Additionally we are shipping SUMO/sentrin Specific Peptidase Family Member 8 Proteins (14) and SUMO/sentrin Specific Peptidase Family Member 8 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SENP8 71599 Q9D2Z4
SENP8 123228 Q96LD8
SENP8 315723 Q5FVJ8
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Top anti-SUMO/sentrin Specific Peptidase Family Member 8 Antibodies at antibodies-online.com

Showing 10 out of 74 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of SENP8 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of SENP8 expression in Raji (A), HeLa (B), Caki1 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB ABIN6266660 at 1/100 staining human kidney tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. ABIN6266660 staining HuvEc by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HuvEc cells, using SENP8 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using SENP8 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of SENP8 polyclonal antibody (ABIN388073) in mouse spleen lysate. SENP8 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Western blot analysis of SENP8 (arrow) using rabbit polyclonal SENP8 Antibody (S19) (ABIN388073). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SENP8 gene. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB 50 μL Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IP, WB SENP8 MaxPab rabbit polyclonal antibody. Western Blot analysis of SENP8 expression in human liver. Immunoprecipitation of SENP8 transfected lysate using anti-SENP8 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with SENP8 monoclonal antibody (M06), clone 2E1 . 100 μL Log in to see 11 to 12 Days
$425.71
Details
Human Rabbit Un-conjugated IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$434.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Western blot analysis of extracts from HuvEc cells, using SENP8 Antibody . The lane on the right is treated with the synthesized peptide. 50 μL Log in to see 11 to 13 Days
$768.40
Details

Top referenced anti-SUMO/sentrin Specific Peptidase Family Member 8 Antibodies

  1. Human Polyclonal SENP8 Primary Antibody for ELISA, WB - ABIN543385 : Mendoza, Shen, Botting, Lewis, Chen, Ink, Hay: NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins. in The Journal of biological chemistry 2003 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal SENP8 Primary Antibody for IP, WB - ABIN530500 : Ehrentraut, Kominsky, Glover, Campbell, Kelly, Bowers, Bayless, Colgan: Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response. in Journal of immunology (Baltimore, Md. : 1950) 2012 (PubMed)

More Antibodies against SUMO/sentrin Specific Peptidase Family Member 8 Interaction Partners

Arabidopsis thaliana SUMO/sentrin Specific Peptidase Family Member 8 (SENP8) interaction partners

  1. DENEDDYLASE1 functions to maintain NEDD8 pathway activity by recovering diverted NEDD8 moieties from proteins of the NEDD8 conjugation machinery. [DEN1]

  2. mutants of a DEN1 homolog from Arabidopsis thaliana have no detectable defects in NEDD8 processing but do accumulate a broad range of NEDD8 conjugates. Neddylation may serve as a regulatory mechanism for cullin and non-cullin proteins. [DEN1]

Human SUMO/sentrin Specific Peptidase Family Member 8 (SENP8) interaction partners

  1. Furthermore, the authors characterized SENP8/DEN1 as the protease that counteracts Ubc12 auto-neddylation, and observed aberrant neddylation of Ubc12 and other NEDD8 conjugation pathway components in SENP8-deficient cells.

  2. In endothelial dysfunction, HDAC2 levels were reciprocally regulated by ectopic expression of NEDD8 and the de-NEDDylating enzyme SENP8.

  3. the expression of SENP8, SAE1, PIAS1, PIAS2 and ZMIZ1 is deregulated in the majority of PTC tissues, likely contributing to the PTC phenotype.

  4. Data indicate that overexpression of SENP8, a NEDD8-specific cysteine protease, resulted in deNEDDylation of E2F1 and promoted its transactivation activity at the p73 gene.

  5. We analyzed whether CSN1 alone can increase DEN1 degradation in HeLa cells.these data suggest that the COP9 signalosome supports proteasome-dependent protein degradation of DEN1/DenA in fungi and in human cells.

  6. A role for SENP8 as a central regulator of the inflammatory process is identified using knockdown and overexpression approaches.

  7. the specificity of NEDD8-specific peptidase SENP8

  8. Data show that the stability of MDM2 is regulated by NEDD8 pathway and identify NEDP1 that deneddylates MDM2, resulting in MDM2 destabilization concomitant with p53 activation.

  9. NEDP1 is likely to play an important role in ubiquitin-mediated proteolysis by controlling the activity of SCF complexes

  10. results suggest a unique role for NEDD8-specific protease 1(DEN1) in regulating the modification of cullin 1 by Nedd8 protein

  11. X-ray structures of the human Nedd8-specific protease, Den1, in a complex with the inhibitor Nedd8 aldehyde, thus revealing a model for the tetrahedral transition state intermediate generated during proteolysis

SUMO/sentrin Specific Peptidase Family Member 8 (SENP8) Antigen Profile

Protein Summary

This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with SENP8

  • SUMO/sentrin peptidase family member, NEDD8 specific L homeolog (senp8.L) antibody
  • Cysteine proteinases superfamily protein (AT5G60190) antibody
  • SUMO/sentrin specific peptidase 8 (Senp8) antibody
  • SUMO/sentrin peptidase family member, NEDD8 specific (SENP8) antibody
  • SUMO/sentrin peptidase family member, NEDD8 specific (Senp8) antibody
  • 9130010J17Rik antibody
  • AU020827 antibody
  • DEN1 antibody
  • F15L12.8 antibody
  • F15L12_8 antibody
  • MGC84956 antibody
  • NEDP1 antibody
  • PRSC2 antibody

Protein level used designations for SENP8

SUMO/sentrin specific peptidase family member 8 , NEDD8-specific protease 1 , SUMO/sentrin specific protease 8 , SUMO/sentrin specific protease family member 8 , deneddylase-1 , protease, cysteine, 2 (NEDD8 specific) , sentrin-specific protease 8 , sentrin/SUMO-specific protease SENP8 , NEDD8 specific-protease cysteine 2 , SUMO sentrin specific protease family member 8 , deneddylase 1 , protease, cysteine 2 , SUMO/sentrin specific peptidase 8 , Sumo1/sentrin/SMT3 specific peptidase 8

GENE ID SPECIES
735058 Xenopus laevis
836141 Arabidopsis thaliana
71599 Mus musculus
123228 Homo sapiens
315723 Rattus norvegicus
487631 Canis lupus familiaris
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