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The protein encoded by SMARCA2 is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Additionally we are shipping SMARCA2 Antibodies (51) and SMARCA2 Proteins (5) and many more products for this protein.
Two BRM promoter polymorphisms were strongly associated with hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)) prognosis but were not associated with increased HCC (show FAM126A ELISA Kits) susceptibility.
This de novo SMARCA2 missense mutation c.3721C>G, p.Gln1241Glu is the only reported mutation on exon 26 outside the ATPase (show DNAH8 ELISA Kits) domain of SMARCA2 to be associated with Nicolaides-Baraitser syndrome and adds to chromatin remodeling as a pathway for epileptogenesis.
We conclude that their features better resemble Coffin-Siris syndrome, rather than Nicolaides-Baraitser syndrome and that these features likely arise from SMARCA2 over-dosage. Pure 9p duplications (not caused by unbalanced translocations) are rare. Copy number analysis in patients with features that overlap with Coffin-Siris syndrome is recommended to further determine their genetic aspects.
BRM could activate JAK2 (show JAK2 ELISA Kits)/STAT3 (show STAT3 ELISA Kits) pathway to promote pancreatic cancer growth and chemoresistance.
BRM gene mutation, chromosome 9 monosomy or BRM deletion and CpG methylation contribute collectively to the loss of BRM expression in poorly differentiated clear cell renal cell carcinoma
BRM-741 and BRM-1321 insertion polymorphisms are associated with susceptibility to cancer.
BRG1 (show SMARCA4 ELISA Kits)/BRM and c-MYC (show MYC ELISA Kits) have an antagonistic relationship regulating the expression of cardiac conduction genes that maintain contractility, which is reminiscent of their antagonistic roles as a tumor suppressor and oncogene (show RAB1A ELISA Kits) in cancer.
Two functional promoter BRM polymorphisms were not associated with pancreatic adenocarcinoma risk, but are strongly associated with survival.
SMARCA4 (show SMARCA4 ELISA Kits) and SMARCA2 deficiency is observed in 5.1% and 4.8% of non-small cell lung cancer
our data suggest that concomitant loss of SMARCA2 and SMARCA4 (show SMARCA4 ELISA Kits) is another hallmark of small cell carcinoma of the ovary, hypercalcemic type-a finding that offers new opportunities for therapeutic interventions.
SWI (show SMARCA1 ELISA Kits)/SNF (show SNRPA ELISA Kits) chromatin remodeler subunits Brg1 (show SMARCA4 ELISA Kits) and Brm are expressed differentially during drug-induced liver injury and regeneration in a mouse model.
these findings described a role for BRG1 (show SMARCA4 ELISA Kits) and BRM in mitochondrial quality control, by regulating mitochondrial number, mitophagy, and mitochondrial dynamics not previously recognized in the adult cardiomyocyte
BRM depletion enhances the proportion of cells expressing markers of osteoblast precursors at the expense of cells able to differentiate along the adipocyte lineage.
Data show that knockdown of component of chromatin remodeling complex Brm or Baf170 (show SMARCC2 ELISA Kits) at different stages promotes reprogramming.
Data reveal stage-specific roles of Brm during skeletal myogenesis, via formation of repressive and activatory SWI (show SMARCA1 ELISA Kits)/SNF (show SNRPA ELISA Kits) complexes.
Brm protects from UV-induced hyperplastic growth in both cutaneous and corneal keratinocytes
Data suggest that Brg1 (show SMARCA4 ELISA Kits) and Brm integrate various proinflammatory cues into cell adhesion molecule (show MCAM ELISA Kits) transactivation in endothelial injury.
A SMARCA2-containing residual SWI (show SMARCA1 ELISA Kits)/SNF (show SNRPA ELISA Kits) complex underlies the oncogenic activity of SMARCA4 (show SMARCA4 ELISA Kits) mutant cancers.
study identifies NO and HDAC2 (show HDAC2 ELISA Kits) nitrosylation as part of a signaling pathway that regulates cortical development and the expression of Brm in neurons
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.
ATP-dependent helicase SMARCA2
, BRG1-associated factor 190B
, SNF2/SWI2-like protein 2
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2
, global transcription activator homologous sequence
, probable global transcription activator SNF2L2
, protein brahma homolog
, sucrose nonfermenting 2-like protein 2
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2
, subunit of the SWI/SNF chromatin remodeling complex
, phasmid Socket Absent PSA-4