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STK10 encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. Additionally we are shipping Serine/Threonine Kinase 10 Proteins (9) and many more products for this protein.
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Binding of phosphatidylinositol 4,5-biphosphate to ezrin (show EZR Antibodies) induces a conformational change permitting the insertion of the LOK C-terminal domain to wedge apart the membrane and F-actin-binding domains of ezrin (show EZR Antibodies). The N-terminal LOK kinase domain can then access a site 40 residues distal from the consensus sequence that collectively direct phosphorylation of the appropriate threonine residue.
The gene signature of OPA1 (show OPA1 Antibodies), CTSA (show CTSA Antibodies), NDUFA1 (show NDUFA1 Antibodies), STK10 and PRDX1 (show PRDX1 Antibodies) was able to identify patients post-implant with a sensitivity of 91% and a specificity of 86% in discrimination between post-implant group and healthy controls.
STK10 functions as a tumor suppressor gene, and dysfunction of STK10 activity either through polymorphism or somatic mutations may confer anti-apoptotic effects contributing to carcinogenesis.
It was shown that lymphocyte-oriented and STE20 kinase (show SLK Antibodies) were sufficient to restrict ezrin (show EZR Antibodies) function to the apical domain. Both kinases were enriched in microvilli and locally activated there.
Opposing roles of serine/threonine kinases MEKK1 (show MAP3K1 Antibodies) and LOK in regulating the CD28 (show CD28 Antibodies) responsive element in T-cells
Stk10 is a novel polo-like kinase (show PLK1 Antibodies) kinase that cooperates with hSlk (show SLK Antibodies) to regulate Plk1 (show PLK1 Antibodies) function in human cells
These studies identify a new ERM (show ETV5 Antibodies) kinase of importance in lymphocytes and confirm the role of ezrin-radixin-moesin (show MSN Antibodies) phosphorylation in regulating cell shape and motility.
kinases, including Slk (show SLK Antibodies), Lok and Mst1 (show MST1 Antibodies), are inhibited by BI-D1870 but to a much lesser extent by BIX 02565 and that phosphorylation of some of their substrates is blocked by BI-D1870 in living cells.
This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.
, serine/threonine-protein kinase 10
, polo-like kinase kinase 1
, serine/threonine-protein kinase 10-A
, germ cell kinase 1